Multicentric, Randomized, Controlled Trial to Evaluate Blood Glucose Control by the Model Predictive Control Algorithm Versus Routine Glucose Management Protocols in Intensive Care Unit Patients

Emerging Treatments and Technologies

¹Department of Internal Medicine, Medical University Hospital, Graz, Austria
²Faculty of Medicine, Charles University, Prague, Czech Republic
³Adult Intensive Care Unit, Royal Brompton Hospital, London, U.K.
⁴Department of Paediatrics, Cambridge University, Cambridge, U.K.
⁵Department of Anaesthesiology and Intensive Care Medicine, Medical University Hospital, Graz, Austria

Address correspondence and reprint requests to Johannes Plank, Department of Internal Medicine, Medical University Graz, Auenbruggerplatz 15, 8036 Graz, Austria. E-mail: johannes.plank{at}klinikum-graz.at

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Figure 1—
Average glucose profiles for MPC treatment (A) and routine management protocols (B) in Prague (▵), Graz (○), and London (▪). Data are means ± SE.
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Figure 2—
Insulin dose and carbohydrate intake at 0–24 h in Graz (A), London (B), and Prague (C) for MPC treatment (♦) and routine management protocols (▪). Data are median (0.25/0.75 quantile).

Table 1—

Baseline characteristics of study participants

Data are means ± SD and n. CABG, coronary artery bypass grafting. APACHE, Acute Physiology and Chronic Health Evaluation.

Table 2—

Glycemic control expressed as percentage of time within a predefined range and average glucose (0–24 h)

Glucose range	Overall			Graz			Prague
Glucose range		MPC	RTP	MPC	RTP	MPC	RTP	MPC	RTP
54–80 mg/dl (3.0–4.4 mmol/l)	0 (0–17)	0 (0–23)	0 (0–14)	0 (0–4)	0 (0–17)	0 (0–13)	0 (0–13)	0 (0–23)
80–110 mg/dl (4.4–6.1 mmol/l)	52 (17–92)*	19 (0–71)	56 (42–67)*	9 (0–21)	42 (17–71)	29 (4–67)	60 (38–92)†	36 (0–71)
>110 mg/dl (6.1 mmol/l)	46 (8–79)*	77 (21–100)	41 (33–58)*	91 (79–100)	54 (29–79)	69 (29–92)	40 (8–50)	57 (21–100)
Average glucose (mg/dl)	117 (102–144)	131 (97–237)	111 (108–131)	152 (115–237)	122 (114–144)	126 (105–154)	111 (102–134)	117 (97–147)

Data are median (min–max).
*
↵* P < 0.01,
†
↵† P < 0.05 for MPC vs. RTP. RTP, routine treatment protocol. Data in bold indicate values within the target range for blood glucose levels (80–110 mg/dl).