High Risk of Cardiovascular Disease in Patients With Type 1 Diabetes in the U.K.
A cohort study using the General Practice Research Database
Article Figures & Tables
Figures
- Figure 1—
Estimated 10-year fatal CVD risk by current (or attained) age in type 1 diabetic (t1d) men and women compared with nondiabetic comparison group (ctr).
Tables
- Table 1—
Absolute and relative risk (HR) for first major CVD events in type 1 diabetic men and women and nondiabetic comparison group free of prior CVD
n Men Women Type 1 diabetes Without diabetes Type 1 diabetes vs. comparison group Type 1 diabetes Without diabetes Type 1 diabetes vs. comparison group Absolute risk per 1,000 person-years Absolute risk per 1,000 person-years HR Absolute risk per 1,000 person-years Absolute risk per 1,000 person-years HR Acute coronary events 269 3.5 (2.7–4.4) 1.3 (1.1–1.5) 3.0 (2.2–4.1) 2.9 (2.2–3.9) 0.5 (0.3–0.7) 7.6 (4.9–12.0) Coronary revascularisations 113 2.0 (1.5–2.8) 0.4 (0.3–0.6) 5.0 (3.2–7.8) 1.5 (1.0–2.3) 0.1 (0.06–0.2) 16.8 (7.5–37.5) Stroke (fatal + nonfatal) 199 2.7 (2.1–3.6) 0.8 (0.7–1.0) 3.7 (2.6–5.3) 2.0 (1.4–2.8) 0.5 (0.3–0.7) 4.8 (3.0–7.9) Major CHD 352 5.1 (4.2–6.3) 1.6 (1.4–1.9) 3.6 (2.8–4.6) 4.1 (3.2–5.2) 0.5 (0.4–0.7) 9.6 (6.4–14.5) Fatal CVD 167 2.8 (2.1–3.7) 0.5 (0.4–0.7) 5.8 (3.9–8.6) 2.5 (1.9–3.5) 0.3 (0.2–0.4) 11.6 (6.7–20.1) Major CVD 508 7.3 (6.1–8.6) 2.3 (2.0–2.6) 3.6 (2.9–4.5) 5.5 (4.4–6.8) 0.9 (0.7–1.2) 7.7 (5.5–10.7) -
Data are risk (95% CI). Absolute risk is the absolute major CVD event rate expressed in person-years at risk. Acute coronary events defined as fatal and nonfatal myocardial infarction and acute CHD death. Coronary revascularizations defined as coronary artery bypass graft, percutaneous transluminal coronary angioplasty, other angioplasty, or other coronary surgery. Major CHD defined as fatal and nonfatal myocardial infarction, coronary revascularizations, and acute CHD death. Major CVD defined as fatal and nonfatal myocardial infarction, coronary revascularizations, acute CHD death, and fatal and nonfatal stroke. Fatal CVD defined as death due to myocardial infarction, acute CHD, or stroke. All HRs are stratified for the matching variables (year of birth and sex).
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- Table 2—
Absolute and relative risk (HR) for major CVD in type 1 diabetic men and women compared with the nondiabetic comparison group stratified by (current) age bands
Men Women Person-years CVD Type 1 diabetes Without diabetes Type 1 diabetes vs. comparison group Person-years CVD Type 1 diabetes Without diabetes Type 1 diabetes vs. comparison group Absolute risk per 1,000 person-years Absolute risk per 1,000 person-years HR Absolute risk per 1,000 person-years Absolute risk per 1,000 person-years HR ≤35 years 52,985 10 0.8 (0.4–1.6) 0.07 (0.02–0.2) 11.3 (2.9–43.8) 47,416 6 0.5 (0.2–1.3) 0.05 (0.01–0.2) 9.8 (1.8–53.6) 35–45 years 29,715 51 4.8 (3.2–7.1) 1.1 (0.8–1.6) 4.4 (2.5–7.6) 21,323 17 3.5 (2.1–6.1) 0.2 (0.09–0.6) 15.4 (5.0–47.3) 45–55 years 17,143 81 10.6 (7.3–15.2) 3.6 (2.8–4.7) 3.0 (1.9–4.8) 13,390 34 10.2 (6.7–15.5) 1.1 (0.6–1.9) 10.1 (5.0–20.4) 55–65 years 8,166 114 39.4 (29.5–52.6) 9.7 (7.7–12.3) 4.1 (2.8–6.0) 6,535 44 22.8 (15.0–34.7) 3.9 (2.6–6.0) 5.7 (3.2–10.4) 65–75 years 3,128 57 35.2 (21.6–57.5) 15.3 (11.3–20.8) 2.3 (1.3–4.1) 3,111 30 38.7 (24.1–62.3) 4.9 (2.8–8.4) 8.3 (4.0–17.2) >75 years 830 37 122.2 (69.4–215.2) 34.2 (23.1–50.6) 3.5 (1.6–7.3) 743 25 87.3 (39.2–194.3) 28.2 (18.0–44.2) 4.0 (1.4–11.2) Total 350 156 -
Data are risk (95% CI). Absolute risk is the absolute major CVD event rate expressed in person-years at risk. All HRs are stratified by year of birth and sex.
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