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Emerging Treatments and Technologies

Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes

  1. Julie Martin, MS, RD1,
  2. Zhong Q. Wang, MD2,
  3. Xian H. Zhang, BS2,
  4. Deborah Wachtel, NP, MPH1,
  5. Julia Volaufova, PHD3,
  6. Dwight E. Matthews, PHD1 and
  7. William T. Cefalu, MD2
  1. 1Division of Endocrinology and Metabolism, University of Vermont, Burlington, Vermont
  2. 2Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana
  3. 3Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana
  1. Address correspondence and reprint requests to William T. Cefalu, MD, Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA 80808. E-mail: cefaluwt{at}pbrc.edu
Diabetes Care 2006 Aug; 29(8): 1826-1832. https://doi.org/10.2337/dc06-0254
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    Figure 1—

    Study design (A) and study flow and numbers (B) for each study period.

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    Figure 2—

    A: Body weight changes for all subjects over the treatment period. •, placebo; □, CrPic. B: Abdominal fat distribution for all subjects over the treatment period. Embedded Image, control; ▪, CrPic. *P < 0.05; **P < 0.01. Data are means± SE.

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  • Table 1—

    Changes observed from baseline for metabolic and phenotypic parameters

    Period 1
    Period 2
    Sulfonylurea + placeboSulfonylurea + placeboSulfonylurea + CrPic
    Glycemia
        Fasting glucose (mg/dl)−19.98 ± 5.330.0009−11.33 ± 8.03NS−31.00 ± 7.370.0002
        GHb (%)−1.07 ± 0.260.0006−0.44 ± 0.43NS−1.16 ± 0.380.0049
        Glucose AUC−7,794 ± 12380.0001−6,454 ± 22890.0092−11,131 ± 21080.0001
        Glucose AUC-B−2,531 ± 8730.008−2,501 ± 1412NS−3,981 ± 12690.0043
    Insulin
        Glucose disposal (mg/min per fat-free mass)21.9 ± 11.8NS15.9 ± 18.5NS28.9 ± 11.30.0209
        Insulin AUC3,460 ± 5220.00012,969 ± 11020.0133,498 ± 9850.0016
        Insulin AUC-B2,604 ± 5180.00011,618 ± 7540.0422,022 ± 6570.0052
        Fasting C-peptide (ng/ml)−0.007 ± 0.030NS0.136 ± 0.111NS0.173 ± 0.093NS
    Indirect calorimetry
        Respiratory quotient0.005 ± 0.006NS−0.006 ± 0.010NS0.005 ± 0.009NS
        REE53.74 ± 28.1NS59.43 ± 40.3NS29.14 ± 36.4NS
    DEXA scans
        % fat0.22 ± 0.44NS1.17 ± 0.310.00080.12 ± 0.35NS
        Fat-free mass0.59 ± 0.40NS0.68 ± 0.46NS1.07 ± 0.440.0227
    Lipids/adipocytokines
        FFAs (mmol/l)−0.12 ± 0.050.018−0.12 ± 0.050.028−0.20 ± 0.050.0007
        Triglycerides (mg/dl)11.43 ± 13.04NS3.68 ± 18.86NS30.32 ± 18.19NS
        Log (Triglycerides)0.09 ± 0.07NS0.06 ± 0.090NS0.13 ± 0.087NS
        Adiponectin (mg/ml)2.06 ± 0.600.0020.74 ± 0.75NS0.93 ± 0.702NS
    • Data are means ± SE or P values. REE, resting energy expenditure.

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Diabetes Care: 29 (8)

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August 2006, 29(8)
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Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes
Julie Martin, Zhong Q. Wang, Xian H. Zhang, Deborah Wachtel, Julia Volaufova, Dwight E. Matthews, William T. Cefalu
Diabetes Care Aug 2006, 29 (8) 1826-1832; DOI: 10.2337/dc06-0254

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Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes
Julie Martin, Zhong Q. Wang, Xian H. Zhang, Deborah Wachtel, Julia Volaufova, Dwight E. Matthews, William T. Cefalu
Diabetes Care Aug 2006, 29 (8) 1826-1832; DOI: 10.2337/dc06-0254
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