Changes in the Glycemic Profiles of Women With Type 1 and Type 2 Diabetes During Pregnancy
Article Figures & Tables
Figures
- Figure 1—
Estimates of glycemic characteristics for women with type 1 (T1) and type 2 (T2) diabetes (DM) obtained from applying generalized linear mixed effects models to the intermittent 7-day continuous glucose profiles. Changes in the overall proportion of time spent euglycemic (70–140 mg/dl) (A), hyperglycemic (>140 mg/dl) (B), hypoglycemic (<70 mg/dl) (C), and hypoglycemia overnight (D) during pregnancy are shown for women with type 1 diabetes (green) and type 2 diabetes (red). The thick lines represent the mean changes in duration of time spent at each threshold, whereas the thin lines reflect changes across gestation for individual subjects. BGL, blood glucose level.
Tables
- Table 1—
Estimates of glycemic characteristics at the end of each trimester for type 1 and type 2 diabetes, obtained from generalized linear mixed effects models
Glycemic measure Trimester 1 Trimester 2 Trimester 3 P Euglycemia Percentage of time 70–140 mg/dl (hours per 24 h) Type 1 43.2% (10.4 h) 49.3% (11.8 h) 56.3% (13.5 h) Diabetes type: 0.0001 Type 2 57.6% (13.8 h) 65.8% (15.8 h) 75.1% (18.0 h) Gestational period: 0.0001 Hyperglycemia Percentage of time >140 mg/dl (hours per 24 h) Type 1 40.5% (9.7 h) 36.4% (8.7 h) 32.7% (7.8 h) Diabetes type: 0.005 Type 2 32.8% (7.9 h) 19.5% (4.7 h) 11.6% (2.8 h) Gestational period: 0.007 Area under the curve >140 mg/dl Type 1 23.04 17.28 12.78 Diabetes type: 0.001 Type 2 14.04 5.76 2.52 Gestational period: 0.0002 Percentage of time >200 mg/dl (hours per 24 h) Type 1 16% (3.8 h) 11.8% (2.8 h) 8.7% (2.0 h) Diabetes type: 0.0004 Type 2 7.9% (1.9 h) 2.9% (0.7 h) 1.0% (0.2 h) Gestational period: 0.0006 Hypoglycemia Percentage of time <70 mg/dl (hours per time period) Overall (24 h) Type 1 14.6% (3.5 h) 13.7% (3.3 h) 12.9% (3.0 h) Diabetes type: 0.04 Type 2 10.2% (2.4 h) 9.6% (2.3 h) 9.1% (2.2 h) Gestational period: NS Nocturnal (2200–0600 h) Type 1 14.6% (1.1 h) 16.2% (1.3 h) 18.1% (1.5 h) Diabetes type: NS Type 2 14.8% (1.1 h) 16.5% (1.3 h) 18.4% (1.5 h) Gestational period: NS Area under the curve <70 mg/dl Type 1 2.52 2.16 1.80 Diabetes type: 0.02 Type 2 1.44 1.26 1.08 Gestational period: NS Percentage of time <50 mg/dl (hours per time period) Overall (24 h) Type 1 5.7% (1.4 h) 4.6% (1.1 h) 3.7% (0.9 h) Diabetes type: 0.02 Type 2 3.0% (0.7 h) 2.5% (0.6 h) 2.0% (0.5 h) Gestational period: NS Nocturnal (2200–0600 h) Type 1 7.3% (0.6 h) 6.3% (0.5 h) 5.4% (0.4 h) Diabetes type: NS Type 2 5.1% (0.4 h) 4.4% (0.3 h) 3.8% (0.3 h) Gestational period: NS Mean blood glucose (mg/dl) Type 1 137 128 119 Diabetes type: 0.08 Type 2 126 117 106 Gestational period: 0.009 A1C (%) Type 1 6.84 6.37 5.90 Diabetes type: NS Type 2 6.56 6.09 5.62 Gestational period: 0.004
In this Issue
