Physical Activity and Metabolic Risk in Individuals With a Family History of Type 2 Diabetes
Article Figures & Tables
Figures
- Figure 1—
Clustered metabolic risk score stratified by quartiles of the total amount of activity (counts · day−1 × 1,000) by accelerometry in sedentary, overweight, middle-aged men and women at high risk of developing diabetes (n = 258). Data are adjusted for sex, age, and monitoring time (P for trend = 0.02).
Tables
- Table 1—
Descriptive characteristics of participants
Men Women P value by ANOVA n 103 155 Age (years) 40.9 ± 6.4 40.7 ± 6.4 NS Weight (kg) 90.4 ± 16.4 73.7 ± 14.4 <0.0001 Height (m) 1.78 ± 0.07 1.64 ± 0.06 <0.0001 BMI (kg/m2) 28.4 ± 4.6 27.4 ± 5.1 NS Fat mass (kg) 22.5 ± 9.4 26.6 ± 10.0 0.01 FFM (kg) 67.9 ± 8.7 47.1 ± 6.2 <0.0001 Waist (cm) 101.4 ± 12.0 88.1 ± 11.8 <0.0001 Systolic blood pressure (mmHg) 127.3 ± 11.2 120.8 ± 13.6 <0.0001 Diastolic blood pressure (mmHg) 81.9 ± 8.8 76.2 ± 9.3 <0.0001 Fasting insulin (mmol · l−1) 55.7 (50.2–61.8) 46.5 (43.4–49.8) 0.02 Fasting glucose (mmol · l−1) 5.10 ± 0.86 4.78 ± 0.52 <0.0001 Triglycerides (mmol · l−1) 1.45 (1.31–1.61) 1.05 (0.98–1.11) <0.0001 HDL (mmol · l−1) 1.22 ± 0.32 1.57 ± 0.38 <0.0001 Vo2max (ml·FFM · min−1) 59.6 ± 11.1 57.8 ± 10.4 NS Time sedentary (min · day−1) 442 ± 97 419 ± 77 0.03 Time light (min · day−1) 309 ± 80 320 ± 68 NS Time moderate and vigorous (min · day−1) 30 ± 18 24 ± 16 0.003 No. of 5-min bouts of MVPA 0.9 ± 0.9 0.8 ± 0.9 NS No. of 10-min bouts of MVPA 0.3 ± 0.5 0.2 ± 0.4 NS Total counts (× 1,000 · day−1) 283 ± 104 264 ± 98 NS -
Data are means ± SD or geometric mean (95% CI). n = 258.
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- Table 2—
Independent associations of patterns of physical activity from accelerometry and intermediary phenotypic risk factors and clustered metabolic risk in middle-aged adults with a family history of type 2 diabetes
Outcome Sedentary P value Light P value MVPA P value Total counts P value Fitness P value Waist (cm) 0.04 (−0.07 to 0.14) 0.51 0.03 (−0.08 to 0.13) 0.63 −0.10 (−0.21 to 0.01) 0.07 −0.09 (−0.20 to 0.01) 0.09 0.005 (−0.003 to 0.013) 0.21 Blood pressure 0.02 (−0.09 to 0.12) 0.77 −0.02 (−0.12 to 0.09) 0.75 −0.03 (−0.14 to 0.07) 0.53 −0.03 (−0.14 to 0.08) 0.59 −0.005 (−0.1 to 0.002) 0.17 Insulin (mol · l−1) 0.10 (0.001–0.19) 0.049 −0.06 (−0.18 to 0.07) 0.40 −0.12 (−0.21 to −0.02) 0.02 −0.14 (−0.23 to −0.04) 0.005 −0.01 (−0.02 to −0.004) 0.003 Glucose (mmol · l−1) −0.02 (−0.13 to 0.09) 0.73 0.03 (−0.08 to 0.14) 0.60 0.05 (−0.06 to 0.16) 0.37 0.002 (−0.11 to 0.11) 0.97 −0.003 (−0.01 to 0.005) 0.50 Triglycerides (mmol · l−1) 0.08 (−0.04 to 0.20) 0.20 −0.12 (−0.23 to −0.001) 0.03 −0.06 (−0.18 to 0.05) 0.27 −0.12 (−0.23 to −0.003) 0.04 −0.004 (−0.01 to 0.004) 0.30 Inverted HDL (mmol · l−1) 0.10 (−0.01 to 0.21) 0.08 −0.06 (−0.17 to 0.05) 0.28 −0.07 (−0.17 to 0.03) 0.17 −0.11 (−0.20 to −0.001) 0.03 0.002 (−0.005 to 0.009) 0.56 Sum Z scores 0.07 (−0.01 to 0.14) 0.10 −0.03 (−0.12 to 0.05) 0.40 −0.09 (−0.17 to −0.008) 0.03 −0.12 (−0.20 to −0.04) 0.004 −0.003 (−0.007 to 0.001) 0.09 -
Data are standardized β-coefficients (95% CI). n = 258. Data on insulin and triglycerides are log transformed. Data are adjusted for sex and age. Data on total counts from accelerometry are additionally adjusted for monitoring time. All subcomponents except waist circumference are additionally adjusted for waist circumference.
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