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Pathophysiology/Complications

Circulating Soluble Transferrin Receptor According to Glucose Tolerance Status and Insulin Sensitivity

  1. José Manuel Fernández-Real, MD, PHD1,
  2. José Maria Moreno1,
  3. Abel López-Bermejo, MD, PHD1,
  4. Berta Chico1,
  5. Joan Vendrell, MD, PHD2 and
  6. Wifredo Ricart, MD1
  1. 1Unit of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomédica de Girona, Girona, Spain
  2. 2Research Unit, University Hospital of Tarragona “Joan XXIII,” Institut Pere Virgili, Tarragona, Spain
  1. Address correspondence and reprint requests to J.M. Fernández-Real, MD, PhD, Unit of Diabetes, EndocrinologyNutrition, Hospital de Girona “Dr. Josep Trueta,” Ctra. França s/n, 17007 Girona, Spain. E-mail: uden.jmfernandezreal{at}htrueta.scs.es
Diabetes Care 2007 Mar; 30(3): 604-608. https://doi.org/10.2337/dc06-1138
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Abstract

OBJECTIVE—The relationships between iron metabolism and type 2 diabetes are bidirectional: iron affects glucose metabolism and glucose metabolism impinges on several iron metabolic pathways. The mechanisms of these interactions depend on poorly known factors. We aimed to study the contribution of the serum soluble transferrin receptor (sTfR).

RESEARCH DESIGN AND METHODS—Circulating sTfR was evaluated in 221 men (97 with normal glucose tolerance [NGT], 36 with impaired glucose tolerance, and 88 with type 2 diabetes). In a subset of these subjects, glucose tolerance (oral glucose tolerance test [OGTT]), minimal model–derived insulin sensitivity, and sTfR during the OGTT were also evaluated.

RESULTS—Men with altered glucose tolerance showed significantly increased sTfR (9.4 ± 4.4 vs. 8.2 ± 2.6 μg/ml, P = 0.02) and higher serum ferritin than men with NGT. Serum sTfR was negatively associated with serum ferritin (r = −0.16, P = 0.02). sTfR correlated with several clinical and metabolic variables such as systolic blood pressure, glycated hemoglobin, and glucose and insulin values during OGTT. Insulin sensitivity was also negatively associated with sTfR in NGT and nonobese subjects. BMI (P = 0.01), serum ferritin (P = 0.025), and insulin sensitivity (P < 0.0001) contributed independently to 21% of sTfR variance. Serum sTfR concentration did not significantly change during the OGTT.

CONCLUSIONS—Both insulin sensitivity and glucose tolerance status are significantly associated with serum sTfR concentrations, although insulin sensitivity predicts independently circulating sTfR, mainly in subjects with NGT. The implications of the interrelationships between iron and glucose metabolism should be investigated further.

  • IGT, impaired glucose tolerance
  • NGT, normal glucose tolerance
  • OGTT, oral glucose tolerance test
  • sTfR, serum transferrin receptor
  • TfR, transferrin receptor

Footnotes

  • Additional information for this article can be found in an online appendix at http://dx.doi.org/10.2337/dc06-1138.

    A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.

    The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C Section 1734 solely to indicate this fact.

    • Accepted October 17, 2006.
    • Received June 3, 2006.
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Diabetes Care: 30 (3)

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Circulating Soluble Transferrin Receptor According to Glucose Tolerance Status and Insulin Sensitivity
José Manuel Fernández-Real, José Maria Moreno, Abel López-Bermejo, Berta Chico, Joan Vendrell, Wifredo Ricart
Diabetes Care Mar 2007, 30 (3) 604-608; DOI: 10.2337/dc06-1138

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Circulating Soluble Transferrin Receptor According to Glucose Tolerance Status and Insulin Sensitivity
José Manuel Fernández-Real, José Maria Moreno, Abel López-Bermejo, Berta Chico, Joan Vendrell, Wifredo Ricart
Diabetes Care Mar 2007, 30 (3) 604-608; DOI: 10.2337/dc06-1138
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