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Pathophysiology/Complications

Kidney Function After Islet Transplant Alone in Type 1 Diabetes

Impact of immunosuppressive therapy on progression of diabetic nephropathy

  1. Paola Maffi, MD, PHD1,
  2. Federico Bertuzzi, MD1,
  3. Francesca De Taddeo, MD1,
  4. Paola Magistretti, PHD1,
  5. Rita Nano, MD1,
  6. Paolo Fiorina, MD, PHD1,
  7. Andrea Caumo, PHD2,
  8. Paolo Pozzi, MD1,
  9. Carlo Socci, MD3,
  10. Massimo Venturini, MD4,
  11. Alessandro del Maschio, MD4 and
  12. Antonio Secchi, MD1
  1. 1Department of Medicine, Transplant Unit, San Raffaele Scientific Institute, Milan, Italy
  2. 2Metabolism and Nutrition Unit, San Raffaele Scientific Institute, Milan, Italy
  3. 3Department of Surgery, San Raffaele Scientific Institute, Milan, Italy
  4. 4Department of Radiology, San Raffaele Scientific Institute, Milan, Italy
  1. Address correspondence and reprint requests to Paola Maffi, MD, PhD, Department of Medicine, Transplant Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy. E-mail: paola.maffi{at}hsr.it
Diabetes Care 2007 May; 30(5): 1150-1155. https://doi.org/10.2337/dc06-1794
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    Figure 1—

    Insulin therapy in 19 patients with type 1 diabetes who received islet transplantation alone and the Edmonton protocol (3). The vertical line across the bars indicates additional islet transplantations.

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    Figure 2—

    sCr (micromol per liter) (upper panel), CrCl (milliliters per second) (middle panel), and 24-h UPE (milligrams per 24 h) (lower panel) in 19 patients with type 1 diabetes who received islet transplantation alone and immunosuppression according to the Edmonton protocol (3). Patients in sirolimus was replaced by MMF are reported until sirolimus withdrawal. Pre tx, pretreatment.

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    Figure 3—

    Twenty-four-hour UPE (milligrams per 24 h) (upper panel) and CrCl (milliliters per second) (lower panel) in the six patients in whom sirolimus were replaced by MMF. The arrows indicate the time of drug change. Pre tx, pretreatment.

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Diabetes Care: 30 (5)

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May 2007, 30(5)
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Kidney Function After Islet Transplant Alone in Type 1 Diabetes
Paola Maffi, Federico Bertuzzi, Francesca De Taddeo, Paola Magistretti, Rita Nano, Paolo Fiorina, Andrea Caumo, Paolo Pozzi, Carlo Socci, Massimo Venturini, Alessandro del Maschio, Antonio Secchi
Diabetes Care May 2007, 30 (5) 1150-1155; DOI: 10.2337/dc06-1794

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Kidney Function After Islet Transplant Alone in Type 1 Diabetes
Paola Maffi, Federico Bertuzzi, Francesca De Taddeo, Paola Magistretti, Rita Nano, Paolo Fiorina, Andrea Caumo, Paolo Pozzi, Carlo Socci, Massimo Venturini, Alessandro del Maschio, Antonio Secchi
Diabetes Care May 2007, 30 (5) 1150-1155; DOI: 10.2337/dc06-1794
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