Circulating Retinol-Binding Protein-4, Insulin Sensitivity, Insulin Secretion, and Insulin Disposition Index in Obese and Nonobese Subjects
Response to Stefan et al.
- José-Manuel Fernández-Real, MD, PHD12,
- Joan Vendrell, MD, PHD3,
- Wifredo Ricart, MD12,
- Cristóbal Richart, MD, PHD4 and
- Montserrat Broch, PHD4
- 1Diabetes, Endocrinology and Nutrition Unit, Dr. Josep Trueta Hospital, Girona, Spain
- 2CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03/010) Spain, Girona Institute for Biomedical Research, Girona, Spain
- 3Reseach Unit, Pere Virgili Institute for Biomedical Research, Tarragona, Spain
- 4Grupo CIBER (CB06/03/0003), Hospital Universitario Joan XXIII de Tarragona, Tarragona, Spain
- Address correspondence to José Manuel Fernández-Real, MD, Unit of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta Hospital, Av. Francia s/n, 17007 Girona, Spain. E-mail: uden.jmfernandezreal{at}htrueta.scs.es
Response to Stefan et al.
We acknowledge the interest of Stefan et al. (1) in our findings in which they tried to replicate in their study of 75 men and women (mean BMI 29 kg/m2). Circulating retinol-binding protein (RBP)-4 did not correlate with insulin secretion even after adjustment for age, sex, and insulin sensitivity. We studied only men (n = 107). Marked sex differences in glucose-stimulated insulin secretion have been described in humans (2) and experimental models (3). Sex has been described to impact insulin secretion, insulin action, and hepatic insulin extraction, which results in substantial differences in the regulation of postprandial glucose metabolism in men and women …
In this Issue
August 2007, 30(8)
Circulating Retinol-Binding Protein-4, Insulin Sensitivity, Insulin Secretion, and Insulin Disposition Index in Obese and Nonobese Subjects
