The Predisposition to Obesity and Diabetes in Offspring of Diabetic Mothers
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Figures
- Figure 1—
Prevalence of type 2 diabetes, by mother's diabetes during and after pregnancy in Pima Indians aged 5–34 years. Reprinted with permission from Dabelea and Pettitt (11). □, Offspring of nondiabetic mothers; ▒, offspring of pre-diabetic mothers; ▪, offspring of diabetic mothers.
- Figure 2—
Prevalence of impaired glucose tolerance (IGT) in offspring of diabetic mothers in three age-groups and in control subjects aged 10–16 years. Reprinted from Silverman et al. (12).
- Figure 3—
Pima Indian sib-pairs discordant for diabetes and exposure to diabetes in utero. Reprinted with permission from Dabelea and Pettitt (11). Left: Of 28 sib-pairs born before or after their mother was diagnosed with diabetes, the diabetic sibling was born after the mother was diagnosed with diabetes (▪) in 21 sib-pairs and before (□) in 7 sib-pairs; odds ratio (OR) 3.0, P < 0.01, for the association between being born before or after the mother was diagnosed with diabetes and diabetes in the offspring. Right: Of 39 sib-pairs born before or after their father was diagnosed with diabetes, the diabetic sibling was born after the father was diagnosed with diabetes (▪) in 22 sib-pairs and before (□) in 17 sib-pairs; OR 1.3, NS, for the association between being born before or after the father was diagnosed with diabetes and diabetes in the offspring.
In this Issue
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- Article
- LONG-TERM ANTHROPOMETRIC AND METABOLIC CONSEQUENCES OF EXPOSURE TO DIABETES DURING PREGNANCY—
- OBESITY AND TYPE 2 DIABETES IN OFFSPRING OF DIABETIC MOTHERS ARE NOT DUE TO GENETIC FACTORS ALONE—
- THE EFFECTS OF EXPOSURE TO MATERNAL DIABETES DURING PREGNANCY ARE SIMILAR REGARDLESS OF MATERNAL DIABETES TYPE—
- MECHANISMS UNDERLYING A POTENTIAL ROLE OF MATERNAL DIABETES ON CHILDHOOD RISK FOR OBESITY AND TYPE 2 DIABETES
- PUBLIC HEALTH IMPLICATIONS OF INCREASING EXPOSURE TO MATERNAL DIABETES IN UTERO—
- FUTURE DIRECTIONS FOR RESEARCH—
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