Effect of Supplementation of Coccinia cordifolia Extract on Newly Detected Diabetic Patients

Clinical Care/Education/Nutrition/Psychosocial Research

¹Division of Nutrition, Institute of Population Health and Clinical Research, St. John's National Academy of health Sciences, Bangalore, India
²Green Chem Limited, Domlur, Bangalore, India
³Division of Endocrinology, Department of Medicine, St. John's Medical College Hospital, St. John's National Academy of Health Sciences, Bangalore, India

Address correspondence and reprint requests to Rebecca Kuriyan, Division of Nutrition, Institute of Population Health and Clinical Research, St. John's National Academy of Health Sciences, Bangalore 560034, India. E-mail: rebecca{at}iphcr.res.in

Diabetes Care 2008 Feb; 31(2): 216-220. https://doi.org/10.2337/dc07-1591

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Figure 1—
Fasting and postprandial blood glucose levels of the subjects of the experimental (dashed line) and placebo (solid line) groups at baseline, day 45, and day 90 of the study. n = 30 in the placebo group and 29 in the experimental group. A: Fasting blood glucose levels at the three different time points. B: Postprandial blood glucose levels at the three time points.

Table 1—

Profile of subjects at baseline

Parameter	Placebo	Experimental	P
Age (years)	47.9 ± 5.9	46.2 ± 6.1	0.29
Body weight (kg)	69.6 ± 13.2	65.0 ± 9.6	0.14
Percentage of fat*	30.1 ± 7.9	28.6 ± 5.2	0.38
Hb (%)†	14.3 ± 2.1	14.6 ± 1.6	0.54
A1C (%)	6.4 ± 0.9	6.7 ± 1.2	0.21
Fasting blood glucose (mg/dl)	125.3 ± 13.8	132.0 ± 20.6	0.15
Postprandial blood glucose (mg/dl)	154.7 ± 44.0	183.2 ± 75.6	0.08
Total cholesterol (mg/dl)	203.6 ± 46.2	207.1 ± 64.6	0.81
HDL cholesterol (mg/dl)	39.4 ± 10.1	44.7 ± 13.4	0.09
LDL cholesterol (mg/dl)	138.3 ± 48.8	141.8 ± 50.3	0.79
Triglycerides (mg/dl)	185.0 ± 74.6	184.0 ± 131.3	0.97

Data are means ± SD. No significant differences were observed in any of the parameters of the subjects of the two groups (independent t test).
*
↵* Calculated from the sum of four skinfold measurements and applying the formulae of Durnin and Womersley (ref. 9). †Measured in grams.

Table 2—

Anthropometric parameters of subjects at baseline and days 45 and 90 of the study

Parameter	Placebo					Experimental		P
Parameter		Baseline	Day 45	Day 90	Baseline	Day 45	Day 90	P
Body weight (kg)	69.6 ± 13.2	69.4 ± 12.9	69.2 ± 13.1	65.0 ± 9.6	64.7 ± 9.4	65.1 ± 9.2	0.55
BMI (kg/m²)	27.5 ± 4.6	27.4 ± 4.7	27.3 ± 4.6	25.1 ± 3.3	25.0 ± 3.2	25.1 ± 3.0	0.46
Waist circumference (cm)	90.2 ± 9.0	90.1 ± 8.2	90.0 ± 8.9	87.9 ± 7.3	87.5 ± 6.9	87.6 ± 6.8	0.83
Hip circumference (cm)	97.0 ± 10.3	96.9 ± 10.3	97.6 ± 10.8	94.7 ± 7.0	94.6 ± 7.1	94.8 ± 6.9	0.49
Percentage of fat (%)*	30.1 ± 7.9	30.1 ± 7.3	31.1 ± 7.4	28.6 ± 5.2	28.3 ± 5.5	28.3 ± 5.6	0.20

Data are means ± SD. n = 30 in the placebo group, and n = 29 in the experimental group. There were no significant interaction between time points and group (repeated-measures ANOVA with group as between-subject factor). There were no significant difference observed between time points for each group (repeated-measures ANOVA).
*
↵* Calculated from the sum of four skinfold measurements and applying the formulae of Durnin and Womersley (ref. 9).