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Cardiovascular and Metabolic Risk

High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes

  1. Abbas Dehghan, MD, DSC1,
  2. Mandy van Hoek, MD2,
  3. Eric J.G. Sijbrands, MD, PHD2,
  4. Albert Hofman, MD, PHD1 and
  5. Jacqueline C.M. Witteman, PHD1
  1. 1Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands
  2. 2Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands
  1. Address correspondence and reprint requests to Dr. J.C.M. Witteman, PhD, Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands. E-mail: j.witteman{at}erasmusmc.nl
Diabetes Care 2008 Feb; 31(2): 361-362. https://doi.org/10.2337/dc07-1276
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Tables

  • Table 1—

    HR (95% CI) for diabetes according to level of serum uric acid

    Serum uric acid quartileParticipants (cases)HR (95% CI)
    Model 1Model 2Model 3
    1 (≤267 μmol/l)1,153 (77)1.00 (Ref.)1.00 (Ref.)1.00 (Ref.)
    2 (268–310 μmol/l)1,141 (94)1.30 (0.96–1.76)1.14 (0.83–1.57)1.08 (0.78–1.49)
    3 (311–370 μmol/l)1,175 (120)1.63 (1.21–2.19)1.23 (0.89–1.67)1.12 (0.81–1.53)
    4 (>370 μmol/l)1,067 (171)2.83 (2.13–3.76)1.92 (1.41–2.62)1.68 (1.22–2.30)
    P for trend<0.001<0.001<0.001
    1 SD increment4,536 (462)1.53 (1.39–1.67)1.37 (1.23–1.52)1.31 (1.18–1.46)
    • Model 1: adjusted for age and sex. Model 2: model 1 + BMI and waist circumference. Model 3: model 2 + systolic and diastolic blood pressure and HDL cholesterol.

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Diabetes Care: 31 (2)

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February 2008, 31(2)
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High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes
Abbas Dehghan, Mandy van Hoek, Eric J.G. Sijbrands, Albert Hofman, Jacqueline C.M. Witteman
Diabetes Care Feb 2008, 31 (2) 361-362; DOI: 10.2337/dc07-1276

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High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes
Abbas Dehghan, Mandy van Hoek, Eric J.G. Sijbrands, Albert Hofman, Jacqueline C.M. Witteman
Diabetes Care Feb 2008, 31 (2) 361-362; DOI: 10.2337/dc07-1276
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