Reciprocal Association of Plasma IGF-1 and Interleukin-6 Levels With Cardiometabolic Risk Factors in Nondiabetic Subjects

Cardiovascular and Metabolic Risk

From the Department of Experimental and Clinical Medicine, University Magna-Græcia of Catanzaro, Catanzaro, Italy

Diabetes Care 2008 Sep; 31(9): 1886-1888. https://doi.org/10.2337/dc08-0553

Article Figures & Tables

Table 1—

Anthropometric and biochemical characteristics of study subjects

	Study subjects	Age- and sex-adjusted correlations between plasma IGF-1 levels and cardiometabolic variables			Age- and sex-adjusted correlations between plasma IL-6 levels and cardiometabolic variables
	Study subjects		Pearson's correlation coefficient (r)	P	Pearson's correlation coefficient (r)	P
Sex (M/F)	80/106	—	—	—	—
Age (years)	41 ± 14	−0.53*	0.0001	0.30*	0.0001
BMI (kg/m²)	30.1 ± 8.4	−0.28	0.0001	0.33	0.0001
Waist circumference (cm)	97 ± 16	−0.29	0.0001	0.35	0.0001
SBP (mmHg)	127 ± 19	−0.15	0.04	0.15	0.04
DBP (mmHg)	80 ± 11	−0.10	0.18	0.13	0.08
Total Cholesterol (mg/dl)	198 ± 41	0.03	0.66	−0.006	0.95
HDL Cholesterol (mg/dl)	54 ± 14	0.11	0.11	−0.07	0.33
Triglyceride (mg/dl)	121 ± 69	−0.19	0.01	0.10	0.15
Fasting Glucose (mgl/dl)	90 ± 14	0.03	0.63	−0.007	0.93
2-h glucose (mg/dl)	117 ± 39	−0.07	0.42	0.13	0.11
Fasting Insulin (μU/ml)	12 ± 7	−0.16	0.03	0.28	0.0001
IGF-1 (ng/ml)	191 ± 90	—	—	−0.15	0.04
IL-6 (pg/ml)	2.5 ± 2.2	−0.15	0.04	—	—
HOMA	2.7 ± 1.8	−0.21	0.004	0.22	0.002
WBGD (mg · kg⁻¹ · min⁻¹)	7.6 ± 3.2	0.29	0.002	−0.35	0.0001
AHA-NHLB–defined metabolic syndrome (yes/no)	60/126 (32.3)	—	—	—	—
High waist circumference (≥102 cm for men and ≥88 cm for women) (yes/no)	91/95 (48.9)	—	—	—	—
High fasting glucose (≥100 mg/dl) (yes/no)	47/139 (25.3)	—	—	—	—
High triglyceride (≥150 mg/dl l) (yes/no)	50/136 (26.8)	—	—	—	—
Low HDL (<40 mg/dl in men or <50 mg/dl in women) (yes/no)	54/132 (29.0)	—	—	—	—
High blood pressure (SBP ≥130 mmHg or DBP ≥85 mmHg) (yes/no)	101/85 (54.6)	—	—	—	—

Data are means ± SD and n (%). Fasting plasma insulin, triglycerides, and IL-6 levels were log transformed for statistical analysis, but values in the table represent a back transformation to the original scale. DBP, diastolic blood pressure; SBP, systolic blood pressure.
↵* Adjusted for sex.