Independent Contribution of Diabetes to Increased Prevalence and Incidence of Atrial Fibrillation
Article Figures & Tables
Figures
- Figure 1
Prevalence of atrial fibrillation by age and diabetes status. A: Data for all subjects. B: Data for men only. C: Data for women only.
- Figure 2
Cumulative age- and sex-adjusted incidence of atrial fibrillation by diabetes status among patients who did not have atrial fibrillation at baseline. A: Data for all subjects. B: Data for men only. C: Data for women only.
Tables
- Table 1
Baseline characteristics of patients with and without diabetes
Diabetes No diabetes P n 17,372 17,372 — Age (years) 58.4 ± 11.5 58.4 ± 11.5 — Sex (% male) 51.2 51.2 — Ethnicity (% nonwhite) 11.9 6.4 <0.0001 Ever smoked (%) 22.2 25.4 <0.0001 Diabetes duration (years) 2.6 ± 3.8 — — BMI (kg/m2) 33.6 ± 7.3 28.9 ± 5.7 <0.0001 Systolic blood pressure (mmHg) 136 ± 19 132 ± 18 <0.0001 Diastolic blood pressure (mmHg) 80 ± 10 79 ± 10 <0.0001 LDL cholesterol (mg/dl) 118 ± 34 132 ± 37 <0.0001 HDL cholesterol (mg/dl) 44 ± 13 52 ± 16 <0.0001 Triglycerides (mg/dl) 225 ± 211 164 ± 108 <0.0001 Estimated glomerular filtration rate (ml/min) 90 ± 30 84 ± 23 <0.0001 A1C (%) 7.8 ± 1.7 — — Comorbidities (%) Ischemic heart disease 10.6 9.8 0.014 History of stroke 4.4 2.9 <0.0001 Valvular disease 1.7 1.7 0.834 Hypertension 47.1 26.9 <0.0001 Heart failure 4.4 1.8 <0.0001 History of depression 15.8 11.7 <0.0001 Data are means ± SD or %.
- Table 2
Cox regression analysis of time to atrial fibrillation among patients without atrial fibrillation or stroke at baseline
Men and women Men only Women only HR (96% CI) P HR (96% CI) P HR (96% CI) P Diabetes 1.16 (1.05–1.28) 0.003 1.09 (0.96–1.24) 0.170 1.26 (1.08–1.46) 0.003 Age ≥65 years 3.10 (2.81–3.43) <0.001 2.69 (2.37–3.07) <0.001 3.80 (3.24–4.46) <0.001 Male sex 1.37 (1.24–1.50) <0.001 — — — — White race 1.60 (1.30–1.96) <0.001 1.58 (1.20–2.07) 0.001 1.61 (1.18–2.19) 0.002 Ever smoked 1.02 (0.91–1.15) 0.751 1.02 (0.88–1.18) 0.812 1.02 (0.84–1.24) 0.845 BMI ≥30 kg/m2 1.22 (1.11–1.34) <0.001 1.29 (1.13–1.46) <0.001 1.13 (0.97–1.31) 0.115 Systolic blood pressure ≥140 mmHg 1.24 (1.13–1.36) <0.001 1.29 (1.13–1.46) <0.001 1.17 (1.01–1.35) 0.032 Ischemic heart disease 1.71 (1.53–1.93) <0.001 1.62 (1.40–1.88) <0.001 1.93 (1.60–2.33) <0.001 Valvular disease 2.18 (1.73–2.74) <0.001 2.05 (1.50–2.81) <0.001 2.40 (1.71–3.36) <0.001 Hypertension 1.32 (1.20–1.46) <0.001 1.29 (1.13–1.46) <0.001 1.34 (1.15–1.55) <0.001 Heart failure 2.33 (1.95–2.78) <0.001 2.39 (1.86–3.07) <0.001 2.18 (1.68–2.82) <0.001
In this Issue
October 2009, 32(10)
Independent Contribution of Diabetes to Increased Prevalence and Incidence of Atrial Fibrillation
