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Original Research

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1

  1. Tihamer Orban, MD1,
  2. Jay M. Sosenko, MD2,
  3. David Cuthbertson, MS3,
  4. Jeffrey P. Krischer, PHD4,
  5. Jay S. Skyler, MD2,
  6. Richard Jackson, MD1,
  7. Liping Yu, MD5,
  8. Jerry P. Palmer, MD6,
  9. Desmond Schatz, MD7,
  10. George Eisenbarth, MD, PHD5 and
  11. for the Diabetes Prevention Trial–Type 1 Study Group
  1. 1Joslin Diabetes Center, Boston, Massachusetts;
  2. 2Division of Endocrinology, University of Miami, Miami, Florida;
  3. 3Pediatrics Epidemiology Center, University of South Florida, Tampa, Florida;
  4. 4Division of Informatics and Biostatistics, University of South Florida, Tampa, Florida;
  5. 5Barbara Davis Center for Childhood Diabetes, Denver, Colorado;
  6. 6Division of Endocrinology/Metabolism, University of Washington, Seattle, Washington;
  7. 7Division of Endocrinology, University of Florida, Gainesville, Florida.
  1. Corresponding author: Jay M. Sosenko, jsosenko{at}med.miami.edu.
Diabetes Care 2009 Dec; 32(12): 2269-2274. https://doi.org/10.2337/dc09-0934
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    Figure 1

    Curves indicate the occurrence of type 1 diabetes (T1D) over follow-up according to the number of autoantibodies present at the initial screening in the Questionnaire cohort (A), in the Trials cohort (B), and in the cohorts combined (C). In all three panels, there were significant trends among the groups of an increasing occurrence of type 1 diabetes with increasing autoantibody number. The numbers (1–4) indicate the number of autoantibodies. (The fraction in parentheses indicates the number who developed type 1 diabetes among the number in the group at baseline.)

  • Figure 2
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    Figure 2

    Curves indicate the occurrence of type 1 diabetes (T1D) in the Questionnaire cohort over follow-up for the presence of one autoantibody and for the additional presence of a second autoantibody at the initial screening. Thus, in each panel the groups that included a specific second positive autoantibody were compared with the group that had one positive autoantibody from any of the others. The panels show that when ICA (A), GAD65 (B), or ICA512 (C) each was present as a second autoantibody, there were significant and similar increases in the occurrence of type 1 diabetes; however, there was no increase when mIAA was present as a second autoantibody (D). The number shown for each curve (1, 2) indicates the number of autoantibodies. Proportions of those who developed type 1 diabetes are shown for each curve. (The fraction in parentheses indicates the number who developed type 1 diabetes among the number in the group at baseline.)

Tables

  • Figures
  • Table 1

    Prevalence of positive autoantibodies at initial screening

    Questionnaire cohortTrials cohort
    n28,507528
    ICA674 (2.4)440 (83.3)
    GAD65907 (3.2)363 (68.8)
    ICA512315 (1.1)258 (48.9)
    mIAA525 (1.8)136 (25.8)
    • Data are n or n (%).

  • Table 2

    Associations of type 1 diabetes occurrence with the presence of single autoantibodies in the Questionnaire cohort at initial screening

    Type 1 diabetes/total (%)HR (95% CI)
    GAD6525/568 (4.4)27.6 (16.8–45.4)*
    ICA5125/110 (4.6)29.5 (11.6–74.7)*
    mIAA0/407 (0)—
    ICA16/407 (3.9)27.5 (15.4–49.0)*
    • Reference group: negative for all autoantibodies (type 1 diabetes/total = 41 of 26,651).

    • ↵*P < 0.001.

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Diabetes Care: 32 (12)

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December 2009, 32(12)
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Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1
Tihamer Orban, Jay M. Sosenko, David Cuthbertson, Jeffrey P. Krischer, Jay S. Skyler, Richard Jackson, Liping Yu, Jerry P. Palmer, Desmond Schatz, George Eisenbarth, for the Diabetes Prevention Trial–Type 1 Study Group
Diabetes Care Dec 2009, 32 (12) 2269-2274; DOI: 10.2337/dc09-0934

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Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1
Tihamer Orban, Jay M. Sosenko, David Cuthbertson, Jeffrey P. Krischer, Jay S. Skyler, Richard Jackson, Liping Yu, Jerry P. Palmer, Desmond Schatz, George Eisenbarth, for the Diabetes Prevention Trial–Type 1 Study Group
Diabetes Care Dec 2009, 32 (12) 2269-2274; DOI: 10.2337/dc09-0934
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