Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1

Curves indicate the occurrence of type 1 diabetes (T1D) in the Questionnaire cohort over follow-up for the presence of one autoantibody and for the additional presence of a second autoantibody at the initial screening. Thus, in each panel the groups that included a specific second positive autoantibody were compared with the group that had one positive autoantibody from any of the others. The panels show that when ICA (A), GAD65 (B), or ICA512 (C) each was present as a second autoantibody, there were significant and similar increases in the occurrence of type 1 diabetes; however, there was no increase when mIAA was present as a second autoantibody (D). The number shown for each curve (1, 2) indicates the number of autoantibodies. Proportions of those who developed type 1 diabetes are shown for each curve. (The fraction in parentheses indicates the number who developed type 1 diabetes among the number in the group at baseline.)