Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy
Article Figures & Tables
Figures
- Figure 1—
Pharmacodynamic profiles. Insulin action, as expressed as GIR, required to maintain euglycemia after a standard bolus of 0.2 unit/kg insulin aspart or lispro. Data are presented as means ± SEM. A: Day 1 of catheter site insertion. B: Day 4 of catheter site insertion.
- Figure 2—
Pharmacodynamic profiles for all subjects on day 1 versus day 4 of catheter site insertion. Insulin action, as expressed as GIR, required to maintain euglycemia after a standard bolus of 0.2 unit/kg insulin aspart or lispro. Data are presented as means ± SEM.
Tables
- Table 1—
Mean plasma glucose levels at baseline and during the clamp procedure
Day 1 Day 4 Aspart Lispro P Aspart Lispro P Baseline plasma glucose (mg/dl) 128 ± 41 145 ± 44 0.42 108 ± 21 142 ± 41 0.05 Plasma glucose during clamp (mg/dl) 99 ± 12 102 ± 11 0.65 98 ± 7 103 ± 11 0.27 -
Data are means ± SD.
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- Table 2—
Comparison of pharmacodynamic parameters for subjects using aspart and lispro
Pharmacodynamic parameters Day 1 P Day 4 P Aspart Lispro Difference (95% CI) Aspart Lispro Difference (95% CI) AUCGIR (mg/kg) 982 ± 83 919 ± 175 63 (−341 to 467) 0.76 839 ± 124 854 ± 116 15 (−354 to 325) 0.93 GIRmax (mg · kg−1 · min−1) 7.3 ± 0.6 6.4 ± 1.1 0.96 (−1.57 to 3.49) 0.46 7.7 ± 0.9 7.3 ± 1.0 0.39 (−2.38 to 3.16) 0.78 TmaxGIR (min) 101 ± 9 92 ± 11 9 (−19 to 37) 0.53 79 ± 9 79 ± 7 0.14 (−23 to 22) 0.99 Time to discontinuation of exogenous glucose (min) 263 ± 10 246 ± 15 16 (−21 to 54) 0.40 208 ± 20 214 ± 17 6 (−58 to 45) 0.81 Ti50 (min) 58 ± 6 46 ± 5 12 (−3 to 27) 0.14 38 ± 4 39 ± 4 1 (−12 to 9) 0.79 Td50 (min) 199 ± 13 191 ± 12 8 (−27 to 42) 0.66 136 ± 10 168 ± 13 32 (−64 to 0.58) 0.07 -
Data are means ± SE unless indicated otherwise.
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- Table 3—
Comparison of pharmacodynamic parameters between day 1 and day 4
Pharmacodynamic parameters All Subjects P Day 1 Day 4 Difference (95%CI) AUCGIR (mg/kg) 948 ± 98 847 ± 82 101 (−151 to 353) 0.42 GIRmax (mg/kg/min) 6.8 ± 0.6 7.5 ± 0.7 −0.69 (−2.49 to 1.12) 0.39 TmaxGIR (min) 97 ± 7 79 ± 5 18 (0.38 to 35) 0.03 Time to discontinuation of exogenous glucose (min) 254 ± 9 211 ± 12 43 (12 to 74) 0.004 Ti50 (min) 51 ± 4 38 ± 3 13 (4 to 22) 0.004 Td50 (min) 195 ± 8 153 ± 9 42 (18 to 66) 0.0004 -
Data are means ± SE.
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