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Diabetes Progression, Prevention, and Treatment

Changing the Treatment Paradigm for Type 2 Diabetes

  1. Stefano Del Prato, MD,
  2. Giuseppe Penno, MD and
  3. Roberto Miccoli, MD
  1. From the Department of Endocrinology and Metabolism, Section of Metabolic Diseases and Diabetes, University of Pisa, Pisa, Italy.
  1. Corresponding author: Stefano Del Prato, delprato{at}immr.med.unipi.it.
Diabetes Care 2009 Nov; 32(suppl 2): S217-S222. https://doi.org/10.2337/dc09-S314
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    Figure 1

    Percentage of type 2 diabetic patients achieving treatment targets for glucose, total cholesterol, and blood pressure in NHANES 1999–2004 (44). □, 1999; ■, 2004.

Tables

  • Figures
  • Table 1

    Barriers in achieving and maintaining glycemic control in type 2 diabetic patients

    • Ineffective diet/exercise initiatives

    • Lack of efficacy of pharmacological agents

    • Conservative management

    • Adverse events

    • Poor compliance

    • Underlying pathophysiology

    • Suboptimal health care systems

  • Table 2

    Available antidiabetic agents for treatment of type 2 diabetes

    Sulfonylureas
        First generation
        Second generation
        Third generation
        Modified release
    Glinides
        Nonsulfonylureic
        Amino acid derivatives
    Biguanides
        Metformin
    Thiazolidinediones
        Rosiglitazone
        Pioglitazone
    Fixed-dose oral hypoglycemic agents combinations
        α-Glucosidase inhibitors
            Acarbose
            Voglibose
        Insulin
            Regular
            Long-acting
            Pre-mixed
        Insulin analogs
            Rapid-acting
            Long-acting
            Inhaled
        GLP-1 analogs
        Dipeptidyl peptidase-4 inhibitors
        Amylin analog
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November 2009, 32(suppl 2)
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Changing the Treatment Paradigm for Type 2 Diabetes
Stefano Del Prato, Giuseppe Penno, Roberto Miccoli
Diabetes Care Nov 2009, 32 (suppl 2) S217-S222; DOI: 10.2337/dc09-S314

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Changing the Treatment Paradigm for Type 2 Diabetes
Stefano Del Prato, Giuseppe Penno, Roberto Miccoli
Diabetes Care Nov 2009, 32 (suppl 2) S217-S222; DOI: 10.2337/dc09-S314
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  • Article
    • INEFFECTIVE DIET AND EXERCISE INITIATIVES
    • LIMITED PHARMACOLOGIC ARMAMENTARIUM
    • CONSERVATIVE MANAGEMENT
    • ADVERSE EVENTS
    • POOR COMPLIANCE
    • UNDERLYING PHYSIOPATHOLOGY
    • SUBOPTIMAL HEALTH CARE SYSTEM
    • CHANGING THE PARADIGM
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Tables
  • Info & Metrics
  • PDF

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More in this TOC Section

Diabetes Progression, Prevention, and Treatment

  • Combined Pharmacologic/Nonpharmacologic Intervention in Individuals at High Risk of Developing Type 2 Diabetes
  • Insulin Therapy for Type 2 Diabetes
  • Nonpharmacologic Therapy and Exercise in the Prevention of Type 2 Diabetes
Show more Diabetes Progression, Prevention, and Treatment

Treatment

  • Initiating Insulin Therapy in Type 2 Diabetic Patients Failing on Oral Hypoglycemic Agents
  • Early Insulin Treatment in Type 2 Diabetes
  • Early Insulin Use in Type 2 Diabetes
Show more Treatment

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