Efficacy of Primary Prevention Interventions When Fasting and Postglucose Dysglycemia Coexist: Analysis of the Indian Diabetes Prevention Programmes (IDPP-1 and IDPP-2)

Original Research

Efficacy of Primary Prevention Interventions When Fasting and Postglucose Dysglycemia Coexist

From the India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, Chennai, India.

Diabetes Care 2010 Oct; 33(10): 2164-2168. https://doi.org/10.2337/dc09-1150

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Figure 1
The selection of original cohorts for the two studies, randomization, and the final outcome in the available subjects at the 3rd-year follow-up are shown. The selection criteria for this analysis and the baseline distribution of subjects in group 1 (iIGT) and group 2 (IGT + IFG) are also shown.

Table 1

Comparison of characteristics of study subjects with iIGT (group 1) and IGT + IFG (group 2)

Table 2

Glycemic outcome up to 3 years in relation to interventions

Table 3

Results of Cox regression analyses (dependent variable: diabetes)

Independent variable	β	Hazard ratio	95% CI	P
Model 1
Intervention vs. control 1	−0.5	0.61	0.47–0.80	0.000
Group 2 vs. group 1	0.69	1.99	1.57–2.52	0.000
Model 2
Intervention vs. control	−0.60	0.55	0.40–0.75	0.000
Group 2 vs. group 1	0.4	1.49	0.86–2.58	0.16
Intervention vs. control × group 2 vs. group 1	0.36	1.44	0.78–2.64	0.24
Model 3
Age (years)	0.001	1.00	0.98–1.02	0.97
Sex	−0.45	0.64	0.46–0.89	0.01
BMI (kg/m²)	0.02	1.02	0.99–1.06	0.173
HOMA-IR	0.01	1.01	0.97–1.05	0.65
Intervention vs. control	−0.64	0.53	0.39–0.72	0.000
Group 2 vs. group 1	0.32	1.38	0.78–2.43	0.27
Intervention vs. control × group 2 vs. group 1	0.45	1.58	0.85–2.92	0.15