Skip to main content
  • More from ADA
    • Diabetes
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes Care

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • Special Article Collections
    • ADA Standards of Medical Care
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • Special Article Collections
    • ADA Standards of Medical Care
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • My Cart

Search

  • Advanced search
Diabetes Care
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • Special Article Collections
    • ADA Standards of Medical Care
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • Special Article Collections
    • ADA Standards of Medical Care
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Online Letters: Observations

Validation of Diabetes Risk Scores for Predicting Diabetes Diagnosed by Oral Glucose Tolerance Test

  1. Hung-Yuan Li, MD1,2,
  2. Yi-Cheng Chang, MD3,
  3. Jung-Nan Wei, PHD4 and
  4. Lee-Ming Chuang, MD, PHD1,2,5
  1. 1Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;
  2. 2Graduate Institute of Clinical Medicine, Medical College, National Taiwan University, Taipei, Taiwan;
  3. 3Genomics Research Center, Academia Sinica, Taipei, Taiwan;
  4. 4Chia Nan University of Pharmacy and Science, Tainan, Taiwan;
  5. 5Graduate Institute of Preventive Medicine, National Taiwan University School of Public Health, Taipei, Taiwan.
  1. Corresponding author: Lee-Ming Chuang, leeming{at}ntu.edu.tw.
Diabetes Care 2010 Feb; 33(2): e26-e26. https://doi.org/10.2337/dc09-1986
PreviousNext
  • Article
  • Info & Metrics
  • PDF
Loading

Recently, we have reported a study evaluating the performance of 11 diabetes risk scores (DRSs) to find subjects with diabetes, metabolic syndrome, and chronic kidney diseases (1), including a DRS developed by that database (DRS-Lin), i.e., in male subjects, x = −8.3805 + age*0.0325 + waist circumference*0.0423 + 0.5866 if using hypertension drugs + 0.2429 if there was a positive diabetes family history; in female subjects, x = −9.523 + age*0.0446 + waist circumference*0.0468 + 0.4264 if using hypertension drugs + 0.5060 if there was a positive diabetes family history; risk of diabetes = 1/(1 + e−x). In that report, diabetes was diagnosed based on fasting plasma glucose instead of a 75-g oral glucose tolerance test (OGTT), which is recommended by the American Diabetes Association (2) and the World Health Organization (3). Here we extend our observation on the performance of those different DRSs for diabetes where the diagnosis was based on OGTT (see the supplemental Table in the online appendix at http://care.diabetesjournals.org/cgi/content/full/dc09-1986/DC1).

From February 2006 to September 2009, 1,205 residents without reported diabetes in Yunlin County, Taiwan, were screened with OGTT. Written informed consent was obtained from each individual, and the study was reviewed and approved by the institutional review board. The mean age was 49.8 ± 13.3 years, including 741 female subjects and 463 male subjects. Diabetes was diagnosed if fasting plasma glucose concentration was >126 mg/dl or 2-h postchallenge plasma glucose concentration was >200 mg/dl. Eighty-six subjects (7.1%) were found to have diabetes. Age; sex; waist circumference; family history of diabetes in grandparents, parents, siblings, or children; and use of hypertension drugs were identified as the risk factors of screened diabetes by logistic regression models. DRS was constructed based on the coefficients in the logistic regression models as follows: Taiwan DRS = 0.0487*age (years) − 0.2887 if male + 0.0696*waist circumference (cm) + 0.0769 if using hypertension drugs + 0.0045 if there was a positive diabetes family history. The area under the receiver operating characteristic curve was 0.76 (95% CI 0.71–0.81) for Taiwan DRS (present report), 0.77 (0.71–0.82) for the Atherosclerosis Risk in Communities study (ARIC) DRS (U.S.), 0.74 (0.69–0.80) for Cambridge DRS (U.K.), 0.72 (0.67–0.77) for DRS-Lin, 0.72 (0.66–0.78) for the Finnish Type 2 DRS (FINDRISC), 0.72 (0.67–0.77) for Oman DRS, 0.72 (0.67–0.77) for Danish DRS, 0.72 (0.67–0.78) for Thai DRS, 0.75 (0.71–0.80) for Asian Indian DRS, 0.68 (0.62–0.74) for Dutch DRS, and 0.68 (0.62–0.74) for the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) DRS (French). All DRSs had a good model fit by Losmer-Lemeshow goodness-of-fit test, except DRS-Lin (P < 0.0001), Cambridge DRS (P = 0.013), and Oman DRS (P = 0.002). The sensitivity and specificity were 0.71 and 0.72 for Taiwan DRS, 0.78 and 0.63 for ARIC DRS, 0.65 and 0.72 for Cambridge DRS, 0.67 and 0.64 for DRS-Lin, 0.77 and 0.58 for FINDRISC, 0.73 and 0.60 for Oman DRS, 0.62 and 0.69 for Danish DRS, 0.74 and 0.62 for Thai DRS, 0.69 and 0.69 for Asian Indian DRS, 0.55 and 0.73 for Dutch DRS, and 0.64 and 0.65 for DESIR DRS, when cutoff value with the least (1-sensitivity)2 + (1-specificity)2 was chosen.

In conclusion, we confirmed that the Taiwan DRS, the ARIC DRS, and the FINDRISC outperformed other DRSs in finding diabetes diagnosed by OGTT, considering the model fit and discrimination ability.

Acknowledgments

No potential conflicts of interest relevant to this article were reported.

  • © 2010 by the American Diabetes Association.

References

  1. ↵
    1. Lin J-W,
    2. Chang Y-C,
    3. Li H-Y,
    4. Chien Y-F,
    5. Wu M-Y,
    6. Tsai R-Y,
    7. Hsieh Y-C,
    8. Chen Y-J,
    9. Hwang J-J,
    10. Chuang L-M
    . Cross-sectional validation of diabetes risk scores for predicting diabetes, metabolic syndrome, and chronic kidney disease in Taiwanese. Diabetes Care 2009; 32: 2294– 2296
    OpenUrlAbstract/FREE Full Text
  2. ↵
    American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2004; 27( Suppl. 1): S5– S10
    OpenUrlCrossRefPubMed
  3. ↵
    World Health Organization, International Diabetes Federation. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation. Geneva, World Health Organization Document Production Services, 2006
View Abstract
PreviousNext
Back to top
Diabetes Care: 33 (2)

In this Issue

February 2010, 33(2)
  • Table of Contents
  • About the Cover
  • Index by Author
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Validation of Diabetes Risk Scores for Predicting Diabetes Diagnosed by Oral Glucose Tolerance Test
(Your Name) has forwarded a page to you from Diabetes Care
(Your Name) thought you would like to see this page from the Diabetes Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Validation of Diabetes Risk Scores for Predicting Diabetes Diagnosed by Oral Glucose Tolerance Test
Hung-Yuan Li, Yi-Cheng Chang, Jung-Nan Wei, Lee-Ming Chuang
Diabetes Care Feb 2010, 33 (2) e26; DOI: 10.2337/dc09-1986

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Validation of Diabetes Risk Scores for Predicting Diabetes Diagnosed by Oral Glucose Tolerance Test
Hung-Yuan Li, Yi-Cheng Chang, Jung-Nan Wei, Lee-Ming Chuang
Diabetes Care Feb 2010, 33 (2) e26; DOI: 10.2337/dc09-1986
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Acknowledgments
    • References
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Tyrosine Kinase Inhibitor Sunitinib Allows Insulin Independence in Long-standing Type 1 Diabetes
  • FGF23 in Type 2 Diabetic Patients: Relationship With Bone Metabolism and Vascular Disease
  • Diabetic Charcot Neuroarthropathy of the Hand: Clinical Course, Diagnosis, and Treatment Options
Show more Online Letters: Observations

Similar Articles

Navigate

  • Current Issue
  • Standards of Care Guidelines
  • Online Ahead of Print
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • Advertising
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes
  • Clinical Diabetes
  • Diabetes Spectrum
  • Scientific Sessions Abstracts
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.