MD-Logic Artificial Pancreas System

Example of 24-h closed-loop session results conducted with subject 1. A: Glucose trace and the insulin treatment during the 24-h closed-loop trial with subject 1. The top graph shows the CGS readings (black line), reference YSI measurements (♦), and the meal times (▴). The bottom graph shows the insulin treatment delivered by the MDLAP (horizontal line = basal rate, vertical lines with ● = insulin boluses). B: Control variability grid analysis over a time period of 24 h for subject 1. C: Control variability grid analysis overnight (0000–0800 h) for subject 1. The nine zones of the CVGA are associated with different qualities of glycemic regulation: A, accurate control; lower B, benign deviations into hypoglycemia; B, benign control deviations; upper B, benign deviations into hyperglycemia; lower C, overcorrection of hypoglycemia; upper C, overcorrection of hyperglycemia; lower D, failure to deal with hypoglycemia; upper D, failure to deal with hyperglycemia; and E, erroneous control. In both figures, the circles represent the minimum/maximum glucose level taken from the relevant time period glucose readings during home care and the rectangles indicate the levels during the MDLAP-regulated closed-loop session. BG, blood glucose.