Increased CD36 Expression Signals Monocyte Activation Among Patients With Type 2 Diabetes

Original Research

¹Department of Medicine, Veteran Affairs Medical Center, Albuquerque, New Mexico;
²Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico;
³Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico;
⁴Clinical Translational Sciences Center, University of New Mexico Health Sciences Center, Albuquerque, New Mexico;
⁵Department of Medicine, Center for Human Nutrition, Washington University, St. Louis, Missouri.

Diabetes Care 2010 Sep; 33(9): 2065-2067. https://doi.org/10.2337/dc10-0460

Article Figures & Tables

Table 1

Unadjusted and adjusted mean CD36 mRNA/protein and Pearson product moment correlations (r)

	CD36 mRNA (log r.u.)		CD36 protein (log r.u.)
	Type 2 diabetes	Nondiabetic control subjects	Type 2 diabetes	Nondiabetic control subjects
n	33	27	33	27
Unadjusted mean	0.23 ± 0.02^†	0.16 ± 0.02	0.28 ± 0.02^§	0.18 ± 0.02
Model 1	0.21 ± 0.02	0.17 ± 0.02	0.27 ± 0.01^*	0.21 ± 0.02
Model 2	0.20 ± 0.02	0.18 ± 0.02	0.26 ± 0.01^†	0.20 ± 0.01
CD36 mRNA (log r.u.)	NA	NA	r = 0.64^‡	r = 0.63^‡
PPAR-γ mRNA (log r.u.)	r = 0.73^‡	r = 0.72^‡	r = 0.33^#	r = 0.46^*
hsCRP (log mg/dl)	r = 0.55^†	r = 0.21	r = 0.45^†	r = 0.43^*
hsIL-6 (log pg/ml)	r = 0.40^*	r = 0.49^†	r = 0.64^‡	r = 0.49^†
TNF-α (log pg/ml)	r = −0.20	r = 0.09	r = −0.28	r = −0.02
Adiponectin (log μg/ml)	r = −0.61^‡	r = −0.67^‡	r = −0.60^‡	r = −0.56^†
BMI (kg/m²)	r = 0.20	r = 0.03	r = 0.09	r = 0.17
HOMA-IR (log r.u.)	r = 0.18	r = 0.03	r = 0.12	r = −0.07
QUICKI (log r.u.)	r = −0.20	r = 0.05	r = −0.16	r = 0.19

Data are least squares means ± SEM unless otherwise indicated. The P value is from a t test of equality of the means. Model 1 adjusts for hypertension (HTN), hsIL-6, PPAR, adiponectin, and QUICKI. Model 2 adjusts for hsIL-6, adiponectin, and QUICKI.
↵*P < 0.05,
↵†P < 0.01,
↵‡P < 0.001,
↵§P < 0.0001,
↵#P = 0.08. HOMA-IR, homeostasis model assessment–insulin resistance; QUICKI, quantitative insulin sensitivity check index; r.u., relative units.