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Original Research

Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide

  1. Michael J. Haller, MD1⇓,
  2. Clive H. Wasserfall, MS2,
  3. Maigan A. Hulme, BS2,
  4. Miriam Cintron, BS1,
  5. Todd M. Brusko, PHD2,
  6. Kieran M. McGrail, BS2,
  7. Theresa M. Sumrall, BS2,
  8. John R. Wingard, MD3,
  9. Douglas W. Theriaque, MS4,
  10. Jonathan J. Shuster, PHD4,
  11. Mark A. Atkinson, PHD2 and
  12. Desmond A. Schatz, MD1
  1. 1Department of Pediatrics, University of Florida, Gainesville, Florida
  2. 2Department of Pathology, University of Florida, Gainesville, Florida
  3. 3Department of Medicine, University of Florida, Gainesville, Florida
  4. 4Department of Epidemiology and Health Policy Research and the General Clinical Research Center, University of Florida, Gainesville, Florida
  1. Corresponding author: Michael J. Haller, hallemj{at}peds.ufl.edu.
Diabetes Care 2011 Dec; 34(12): 2567-2569. https://doi.org/10.2337/dc11-1406
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Article Figures & Tables

Tables

  • Table 1

    Baseline and postinfusion characteristics of autologous UCB recipients

    PreinfusionPostinfusion(Preinfusion–to–1 year ratio) − 1(Preinfusion–to–2 year ratio) − 1
    3 months6 months9 months1 year1.5 years2 years
    HbA1c (%)7.4 (6.5–8.4) {24}7.5 (7.1–8.5) {24} [NS]7.5 (7.1–8.5) {23} [NS]7.1 (6.7–7.1) {23} [NS]7.1 (6.7–7.8) {24} [NS]7.1 (6.6–7.9) {20} [NS}7.6 (7.2–8.0) {21} [NS]−0.2 (−0.6 to 0.7) {24} [NS]0.1 (−0.5 to 0.9) {21} [NS]
    Insulin use (units/kg per day)0.37 (0.22–0.51) {24}0.46 (0.28–0.58) {23} [NS]0.58 (0.44–0.79) {23} [NS]0.58 (0.44–0.79) {23} [NS]0.69 (0.55–0.81) {23} [<0.001]0.63 (0.57–0.77) {20} [0.001]0.66 (0.61–0.81) {21} [<0.001]−0.22 (−0.53 to −0.085) {20} [<0.001]−0.44 (−0.68 to −0.21) {21} [<0.001]
    Peak C-peptide (ng/mL)1.16 (0.7–1.71) {22}0.83 (0.24–1.28) {24} [0.006]0.73 (0.47–1.35) {23} [0.003]0.6 (0.08–1.36) {20} [<0.001]0.28 (0.16–0.86) {21} [<0.001]0.17 (0–0.95) {19} [<0.001]0.05 (0–0.58) {21} [<0.001]−0.53 (−1.0 to −0.16) {20} [<0.001]−0.7 (−1.4 to −0.5) {19} [<0.001]
    AUC C-peptide (ng/mL)0.95 (0.51–1.4) {22}0.66 (0.2–1.0) {24} [0.002]0.64 (0.2–1.1) {23} [<0.001]0.46 (0.03–1.1) {20} [<0.001]0.22 (0.02–0.63) {21} [<0.001]0.15 (0–0.7) {21} [<0.001]0.02 (0–0.52) {21} [<0.001]−0.49 (−0.82 to −0.11) {21} [<0.001]−0.6 (−1.0 to −0.37) {19} [<0.001]
    IA-2A11.0 (1.8–23.1) {22}7.5 (0.69–20) {21} [0.01]4.5 (0.2–16.3) {22} [0.01]4.1 (0–16.5) {20} [NS]2.9 (0–14.5) {21} [0.001]2.2 (0–9.9) {18} [<0.001}2.3 (0–8.9) {18} [<0.001]−3.8 (−7.5 to −0.35) {20} [0.001]−7.2 (−12.7 to −2.3) {16} [<0.001]
    GADA2.5 (0.7–12.3) {23}1.7 (0.3–6.4) {21} [NS]1.95 (0.2–9.2) {22} [NS]2.0 (0.5–15.7) {20} [NS]2.6 (0.3–15.8) {22} [NS]1.9 (0.4–5.3) {18} [0.01]1.2 (0.2–8.9) {19} [NS]−1.0 (−3.6 to 0.6) {22} [NS]−0.8 (−8.4 to 0) {18} [NS]
    WBC (cell × 109/L)5.6 (5.0–7.3) {23}5.75 (4.7–7.85) {24} [NS]6.1 (4.7–6.9) {23} [NS]5.8 (4.6–6.9) {20} [NS]5.5 (4.4–6.7) {22} [NS]5.8 (3.9–7.6) {18} [NS]5.5 (4.25–7.35) {20} [NS]−0.4 (−0.7 to 0.2) {22} [NS]−0.5 (−1.8 to 0.6) {19} [NS]
    CD4-to-CD8 ratio1.89 (1.5–2.4) {22}1.89 (1.6–2.2) {23} [NS]1.89 (1.5–1.9) {23} [NS]1.96 (1.6–2.2) {20} [NS]1.97 (1.7–2.2) {22} [NS]1.90 (1.4–2.1) {18} [NS]2.15 (1.7–2.4) {20} [NS]0.1 (−0.28 to −0.24) {21} [NS]0.15 (−0.2 to −0.4) {18} [NS]
    Peripheral blood Treg (%)3.1 (0.8–5.4) {22}4.1 (1.0–5.5) {23} [NS]4.4 (2.0–7.5) {23} [0.04]3.6 (1.9–5.1) {20} [NS]4.4 (2.0–7.6) {22} [NS]3.0 (1.8–5.1) {20} [NS]3.3 (1.9–6.5) {20} [NS]0.13 (−1.3 to 1.0) {21} [NS]0.52 (−1.8 to 2.9) {18} [NS]
    CD45RA Treg (%)39.0 (25.7–45.9) {22}42.6 (27.8–49.8) {23} [NS]40.5 (34.1–51.3) {23} [NS]43.5 (37.9–54.3) {20} [0.001]40.9 (31.9–50.4) {22} [NS]40.2 (29.9–46.2) {18} [NS]42.8 (28.6–48.8) {20} [NS]2.24 (−5.53 to 11.0) {21} [NS]1.82 (−3.8 to 1.8) {18} [NS]
    • Data are median (interquartile range) and {n} [P value vs. baseline]; N = 24 (10 males, 14 females), median age at infusion 5.1 years (3.4–6.9). IA-2A, insulinoma-associated 2 antibody; GADA, GAD antibody; WBC, white blood cell count.

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Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide
Michael J. Haller, Clive H. Wasserfall, Maigan A. Hulme, Miriam Cintron, Todd M. Brusko, Kieran M. McGrail, Theresa M. Sumrall, John R. Wingard, Douglas W. Theriaque, Jonathan J. Shuster, Mark A. Atkinson, Desmond A. Schatz
Diabetes Care Dec 2011, 34 (12) 2567-2569; DOI: 10.2337/dc11-1406

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Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide
Michael J. Haller, Clive H. Wasserfall, Maigan A. Hulme, Miriam Cintron, Todd M. Brusko, Kieran M. McGrail, Theresa M. Sumrall, John R. Wingard, Douglas W. Theriaque, Jonathan J. Shuster, Mark A. Atkinson, Desmond A. Schatz
Diabetes Care Dec 2011, 34 (12) 2567-2569; DOI: 10.2337/dc11-1406
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