Risk of Malignant Neoplasm of the Pancreas in Relation to Diabetes
A population-based study in Taiwan
Abstract
OBJECTIVE We prospectively assessed the age- and sex-specific incidence and relative risk of malignant neoplasm of the pancreas in Taiwan’s diabetic population.
RESEARCH DESIGN AND METHODS A total of 615,532 diabetic patients and 614,871 age- and sex-matched control subjects were linked to inpatient claims (2000–2006) to identify the admissions for malignant neoplasm of the pancreas (ICD-9: 157). The Cox proportional hazards regression model was used to estimate the age- and sex-specific relative risk of pancreatic neoplasm.
RESULTS Compared with the control group, the diabetic patients had a significantly increased risk of pancreatic cancer (hazard ratio [HR] 1.54 [95% CI 1.39–1.71]). The higher and significant age-specific HRs were observed in diabetic men (1.91) and women (1.80) aged 45–65 years.
CONCLUSIONS Middle-aged diabetic men and women were associated with the most increased risk of malignant neoplasm of the pancreas.
- Received October 22, 2010.
- Accepted February 5, 2011.
- © 2011 by the American Diabetes Association.
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