Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies

Original Research

¹Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado
²Department of Pediatrics, Pediatric Epidemiology Center, University of South Florida, Tampa, Florida
³Benaroya Research Institute, University of Washington, Seattle, Washington
⁴School of Clinical Sciences, University of Bristol, Bristol, U.K.
⁵Division of Endocrinology, University of Miami, Miami, Florida
⁶Departments of Epidemiology and Biostatistics and Medicine, University of Western Ontario, London, Ontario, Canada

Diabetes Care 2012 Jun; 35(6): 1213-1218. https://doi.org/10.2337/dc11-2081

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Figure 1
Cumulative incidences of diabetes in relatives positive for one standard BAA (IAA, GAD65A, or IA-2A) with or without ZnT8A. ICA⁺ relatives are excluded. The 95% confidence limits are indicated by the shaded areas. Diabetes risk was higher among ZnT8A⁺ relatives (P < 0.0001). mIAA, micro IAA; AB, antibody.
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Figure 2
Cumulative incidences of diabetes in multiple autoantibody (at least two standard BAA) positive relatives with or without ZnT8A. ICA⁺ relatives are excluded. The 95% confidence limits are indicated by the shaded areas. Diabetes risk was higher among ZnT8A⁺ relatives (P = 0.0001).
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Figure 3
The cumulative incidence of diabetes in relatives positive for two BAA (any two of GAD65A, IAA, IA-2A, and ZnT8A) with or without ICA. The 95% confidence limits are indicated by the shaded area. Diabetes risk was higher among ICA⁺ relatives (P < 0.0001). AB, antibody.