Original Research

Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies

  1. Liping Yu, MD1,
  2. David C. Boulware, MS2,
  3. Craig A. Beam, PHD2,
  4. John C. Hutton, PHD1,
  5. Janet M. Wenzlau, PHD1,
  6. Carla J. Greenbaum, MD3,
  7. Polly J. Bingley, MD4,
  8. Jeffrey P. Krischer, PHD2,
  9. Jay M. Sosenko, MD5,
  10. Jay S. Skyler, MD5,
  11. George S. Eisenbarth, MD, PHD1,
  12. Jeffrey L. Mahon, MD, MSC6⇓ and
  13. for the Type 1 Diabetes TrialNet Study Group*
  1. 1Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver, Aurora, Colorado
  2. 2Department of Pediatrics, Pediatric Epidemiology Center, University of South Florida, Tampa, Florida
  3. 3Benaroya Research Institute, University of Washington, Seattle, Washington
  4. 4School of Clinical Sciences, University of Bristol, Bristol, U.K.
  5. 5Division of Endocrinology, University of Miami, Miami, Florida
  6. 6Departments of Epidemiology and Biostatistics and Medicine, University of Western Ontario, London, Ontario, Canada
  1. Corresponding author: Jeffrey L. Mahon, jl.mahon{at}lhsc.on.ca.
Diabetes Care 2012 Jun; 35(6): 1213-1218. https://doi.org/10.2337/dc11-2081

Article Figures & Tables

Figures

  • Figure 1
    Figure 1

    Cumulative incidences of diabetes in relatives positive for one standard BAA (IAA, GAD65A, or IA-2A) with or without ZnT8A. ICA+ relatives are excluded. The 95% confidence limits are indicated by the shaded areas. Diabetes risk was higher among ZnT8A+ relatives (P < 0.0001). mIAA, micro IAA; AB, antibody.

  • Figure 2
    Figure 2

    Cumulative incidences of diabetes in multiple autoantibody (at least two standard BAA) positive relatives with or without ZnT8A. ICA+ relatives are excluded. The 95% confidence limits are indicated by the shaded areas. Diabetes risk was higher among ZnT8A+ relatives (P = 0.0001).

  • Figure 3
    Figure 3

    The cumulative incidence of diabetes in relatives positive for two BAA (any two of GAD65A, IAA, IA-2A, and ZnT8A) with or without ICA. The 95% confidence limits are indicated by the shaded area. Diabetes risk was higher among ICA+ relatives (P < 0.0001). AB, antibody.

Tables

  • Table 1
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Diabetes Care: 43 (11)

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Zinc Transporter-8 Autoantibodies Improve Prediction of Type 1 Diabetes in Relatives Positive for the Standard Biochemical Autoantibodies
Liping Yu, David C. Boulware, Craig A. Beam, John C. Hutton, Janet M. Wenzlau, Carla J. Greenbaum, Polly J. Bingley, Jeffrey P. Krischer, Jay M. Sosenko, Jay S. Skyler, George S. Eisenbarth, Jeffrey L. Mahon, for the Type 1 Diabetes TrialNet Study Group
Diabetes Care Jun 2012, 35 (6) 1213-1218; DOI: 10.2337/dc11-2081
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