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Original Research

Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in Patients With Inflammatory Rheumatologic Disease

  1. Carolyn J. Petersons, MBBS1,2⇑,
  2. Brenda L. Mangelsdorf, RN2,
  3. Arthur B. Jenkins, PHD3,4,
  4. Anne Poljak, PHD5,
  5. Malcolm D. Smith, PHD1,6,
  6. Jerry R. Greenfield, PHD3,7,
  7. Campbell H. Thompson, PHD1,8 and
  8. Morton G. Burt, PHD1,2
  1. 1Faculty of Health Sciences, Flinders University, Adelaide, Australia
  2. 2Southern Adelaide Diabetes and Endocrine Services, Repatriation General Hospital, Adelaide, Australia
  3. 3Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Sydney, Australia
  4. 4School of Health Sciences, University of Wollongong, Wollongong, Australia
  5. 5Bioanalytical Mass Spectrometry Facility and School of Medical Sciences, University of New South Wales, Sydney, Australia
  6. 6Department of Rheumatology, Repatriation General Hospital, Adelaide, Australia
  7. 7Department of Endocrinology, St. Vincent’s Hospital, Sydney, Australia
  8. 8Discipline of Medicine, University of Adelaide, Adelaide, Australia
  1. Corresponding author: Carolyn J. Petersons, carolynpetersons{at}yahoo.com.au
Diabetes Care 2013 Sep; 36(9): 2822-2829. https://doi.org/10.2337/dc12-2617
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    Figure 1

    Endogenous glucose production in non-GC users before and after administration of low-dose prednisolone for 7–10 days and in long-term GC users. Data are mean ± SD. B, basal EGP; LDC, low-dose clamp; HDC, high-dose clamp. *P = 0.05 compared with basal EGP in non-GC users at baseline. #P < 0.05 compared with percentage of insulin suppression of EGP in non-GC users at baseline.

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    Figure 2

    A: Mean glucose infusion rate at steady state during high-dose clamp study corrected for FFM and for serum insulin concentration (M/I) in non-GC users before and after administration of low-dose prednisolone for 7–10 days and in long-term GC users. Data are mean ± SD. *P < 0.05 compared with non-GC users at baseline. B: Rate of oxidative (white bars) and nonoxidative (black bars) Rd at steady state during high-dose clamp study in non-GC users before and after administration of low-dose prednisolone for 7–10 days and in long-term GC users. Data are mean ± SD. *P < 0.05 compared with total Rd in non-GC users at baseline. #P < 0.05 compared with percentage of nonoxidative glucose disposal in non-GC users at baseline.

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    Figure 3

    A: First-phase insulin secretion (area under the curve [AUC] insulin:AUC glucose) in non-GC users before and after administration of low-dose prednisolone for 7–10 days and in long-term GC users. Data are mean ± SD. *P < 0.05 compared with non-GC users at baseline. B: Second-phase insulin secretion (AUC insulin:AUC glucose) in non-GC users before and after administration of low-dose prednisolone for 7–10 days and in long-term GC users. Data are mean ± SD. *P < 0.05 compared with non-GC users at baseline.

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Diabetes Care: 36 (9)

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September 2013, 36(9)
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Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in Patients With Inflammatory Rheumatologic Disease
Carolyn J. Petersons, Brenda L. Mangelsdorf, Arthur B. Jenkins, Anne Poljak, Malcolm D. Smith, Jerry R. Greenfield, Campbell H. Thompson, Morton G. Burt
Diabetes Care Sep 2013, 36 (9) 2822-2829; DOI: 10.2337/dc12-2617

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Effects of Low-Dose Prednisolone on Hepatic and Peripheral Insulin Sensitivity, Insulin Secretion, and Abdominal Adiposity in Patients With Inflammatory Rheumatologic Disease
Carolyn J. Petersons, Brenda L. Mangelsdorf, Arthur B. Jenkins, Anne Poljak, Malcolm D. Smith, Jerry R. Greenfield, Campbell H. Thompson, Morton G. Burt
Diabetes Care Sep 2013, 36 (9) 2822-2829; DOI: 10.2337/dc12-2617
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