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e-Letters: Observations

Dry Eye Syndrome in Subjects With Diabetes and Association With Neuropathy

  1. Vasilis Achtsidis1,
  2. Ioanna Eleftheriadou2,
  3. Eleftheria Kozanidou3,
  4. Konstantine I. Voumvourakis4,
  5. Eleftherios Stamboulis4,
  6. Panos G. Theodosiadis1 and
  7. Nicholas Tentolouris2
  1. 1Second Department of Ophthalmology, Attikon University Hospital, University of Athens, Athens, Greece
  2. 2First Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Athens, Greece
  3. 3Second Department of Internal Medicine, St. Panteleimon General Hospital of Nikaia, Piraeus, Greece
  4. 4Second Department of Neurology, Attikon University Hospital, University of Athens Medical School, Athens, Greece
  1. Corresponding author: Vasilis Achtsidis, billachtsidis{at}yahoo.gr.
Diabetes Care 2014 Oct; 37(10): e210-e211. https://doi.org/10.2337/dc14-0860
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Diabetes mellitus has been identified as a risk factor for dry eye syndrome (DES). The prevalence of DES in diabetes has been reported to be up to 54.3% (1). DES compromises quality of life because it induces ocular discomfort and visual disturbance and may be complicated by corneal epithelial defects, erosions, or ulcers. Therefore, it is recognized as a growing public health problem that should be diagnosed and treated (1).

Among the various forms of diabetic neuropathies, chronic sensorimotor distal symmetric polyneuropathy (PN) is the most common form and may manifest with symptoms while sensory and motor deficits are detected (2). The cornea is one of the most densely innervated parts of the human body containing myelinated A-δ and unmyelinated C fibers, deriving its innervation from the ophthalmic division of the trigeminal nerve. Recent data suggested that patients with PN have corneal nerve fiber damage and reduced corneal sensitivity (3). According to the International Dry Eye WorkShop (DEWS), the reduced corneal sensitivity favors the occurrence of DES in two ways: first by decreasing the reflex-induced lacrimal secretion and second by reducing the blink rate and increasing evaporative tear loss (4). Although PN and DES are common in diabetes, the relationship between them is not known. The research hypothesis we tested herein was that subjects with PN may more often have DES as a result of reduced corneal sensitivity and impaired balance of tear production/evaporation.

A total of 61 subjects with type 2 diabetes and 38 control subjects were recruited in this cross-sectional study. PN was assessed by using the neuropathy disability and neuropathy symptom scores (5). We used the DEWS recommendation to assess DES (4). Moreover, the Schirmer I test, tear film breakup time (TBUT) and corneal sensitivity were evaluated (3). Subjects who wore contact lenses, had ocular/glaucoma drops, were on antihistamine or antidepressant medications, or underwent ocular surgery were excluded.

PN was diagnosed in 34 patients (55.7%). DES was diagnosed more often in subjects with PN than in those without PN and control subjects (76.5, 44.4, and 28.9%, respectively; P < 0.001). The values of the Schirmer I test, TBUT, and corneal sensitivity were worse in patients with PN than in those without PN and control subjects (P < 0.001). There were significant correlations (P < 0.05) between neuropathy disability, Schirmer I test, TBUT, and corneal sensitivity (Table 1).

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Table 1

Ocular findings in control subjects and in subjects with diabetes according to the presence (PN+) or absence (PN−) of diabetic PN

Limitations of the study are 1) the small number of participants; 2) its cross-sectional design; 3) only patients with type 2 diabetes were included; and 4) the function of the corneal nerve plexus but not the anatomical corneal innervation and the blink rate was evaluated.

In conclusion, we have shown that DES is particularly common in patients with type 2 diabetes who have PN, and it is associated with reduced corneal sensitivity. Corneal hypoesthesia reduces patient’s symptoms, and DES might be asymptomatic and insidious. We suggest that patients with PN be screened for DES and probably treated long-term for the prevention of ocular surface damage.

Article Information

Acknowledgments. This work was approved by the University of Athens Medical School Clinical Research Ethics Committee.

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Author Contributions. V.A. executed the conception and design, collected and researched data, and wrote and reviewed the manuscript. I.E. collected data and researched data and edited the manuscript. E.K. reviewed/edited the manuscript and researched data. K.I.V. and E.S. reviewed/edited the manuscript. P.G.T. researched data and reviewed/edited the manuscript. N.T. executed the conception and design, analyzed and researched data, and wrote and reviewed the manuscript. V.A. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

  • © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

References

  1. ↵
    1. Manaviat MR,
    2. Rashidi M,
    3. Afkhami-Ardekani M,
    4. Shoja MR
    . Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmol 2008;8:10. DOI: 10.1186/1471-2415-8-10
    OpenUrlCrossRefPubMed
  2. ↵
    1. Boulton AJ,
    2. Vinik AI,
    3. Arezzo JC,
    4. et al.,
    5. American Diabetes Association
    . Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care 2005;28:956–962
    OpenUrlFREE Full Text
  3. ↵
    1. Tavakoli M,
    2. Kallinikos PA,
    3. Efron N,
    4. Boulton AJ,
    5. Malik RA
    . Corneal sensitivity is reduced and relates to the severity of neuropathy in patients with diabetes. Diabetes Care 2007;30:1895–1897
    OpenUrlFREE Full Text
  4. ↵
    The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007;5:75–92
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Young MJ,
    2. Boulton AJ,
    3. MacLeod AF,
    4. Williams DR,
    5. Sonksen PH
    . A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 1993;36:150–154
    OpenUrlCrossRefPubMedWeb of Science
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Dry Eye Syndrome in Subjects With Diabetes and Association With Neuropathy
Vasilis Achtsidis, Ioanna Eleftheriadou, Eleftheria Kozanidou, Konstantine I. Voumvourakis, Eleftherios Stamboulis, Panos G. Theodosiadis, Nicholas Tentolouris
Diabetes Care Oct 2014, 37 (10) e210-e211; DOI: 10.2337/dc14-0860

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Dry Eye Syndrome in Subjects With Diabetes and Association With Neuropathy
Vasilis Achtsidis, Ioanna Eleftheriadou, Eleftheria Kozanidou, Konstantine I. Voumvourakis, Eleftherios Stamboulis, Panos G. Theodosiadis, Nicholas Tentolouris
Diabetes Care Oct 2014, 37 (10) e210-e211; DOI: 10.2337/dc14-0860
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