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Pathophysiology/Complications

The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance

  1. Wei Hao1⇑,
  2. Carla J. Greenbaum2,
  3. Jeffrey P. Krischer3,
  4. David Cuthbertson4,
  5. Jennifer B. Marks5 and
  6. Jerry P. Palmer1,6
  1. 1Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA
  2. 2Benaroya Research Institute, Virginia Mason Research Center, Seattle, WA
  3. 3Divison of Informatics and Biostatistics, University of South Florida, Tampa, FL
  4. 4Pediatric Epidemiology Center, University of South Florida, Tampa, FL
  5. 5Division of Endocrinology, Diabetes, and Metabolism, University of Miami, Miami, FL
  6. 6Department of Veterans Affairs, Puget Sound Health Care System, Seattle, WA
  1. Corresponding author: Wei Hao, whao{at}u.washington.edu.
Diabetes Care 2015 May; 38(5): 891-896. https://doi.org/10.2337/dc14-1825
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    Figure 1

    C-peptide during OGTTs performed on and off IV-I therapy. Values are adjusted mean C-peptide ± standard errors of the mean (n = 37 paired OGTTs).

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    Figure 2

    Relationship between fasting and stimulated C-peptide (nanograms per milliliter) off insulin (panel A) and on IV-I (panel B) (n = 37 paired OGTTs).

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    Figure 3

    Glucose during OGTTs performed on and off IV-I therapy. Values are adjusted mean glucose ± standard errors of the mean (n = 37 paired OGTTs).

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    Figure 4

    Comparison of 2-h OGTT glucose levels off and on IV-I in each individual (n = 37 paired OGTTs).

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  • Table 1

    Demographics of the subjects in each group

    IV-I group 
(n = 30)SC-I group 
(n = 15)
    Age at randomization (years)16.5 ± 12.420.1 ± 12.9
    BMI18.7 ± 4.220.4 ± 4.8
    Sex
     Male17 (56.7)9 (60)
     Female13 (43.3)6 (40)
    Race/ethnicity
     Non-Hispanic white29 (96.7)15 (100)
     Unknown1 (3.3)
    Impaired glucose tolerance12 (40)6 (40)
    • Values are mean ± SD or n (%).

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Diabetes Care: 38 (5)

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May 2015, 38(5)
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The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance
Wei Hao, Carla J. Greenbaum, Jeffrey P. Krischer, David Cuthbertson, Jennifer B. Marks, Jerry P. Palmer
Diabetes Care May 2015, 38 (5) 891-896; DOI: 10.2337/dc14-1825

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The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance
Wei Hao, Carla J. Greenbaum, Jeffrey P. Krischer, David Cuthbertson, Jennifer B. Marks, Jerry P. Palmer
Diabetes Care May 2015, 38 (5) 891-896; DOI: 10.2337/dc14-1825
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