Diabetes Care: 38 (6)

June 01 2015; volume 38 issue 6

In This Issue

Open Access
In This Issue of Diabetes Care
Diabetes Care 2015 Jun; 38 (6): 945-946. https://doi.org/10.2337/dc15-ti06

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Editor’s Note

Open Access
A Special Thanks to the Reviewers of Diabetes Care
Diabetes Care 2015 Jun; 38 (6): 947. https://doi.org/10.2337/dc15-en06

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Commentaries

Open Access
Smoke or Fire? Acute Pancreatitis and the Liraglutide Trials
Edwin A.M. Gale

Diabetes Care 2015 Jun; 38 (6): 948-950. https://doi.org/10.2337/dc15-0346

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Open Access
Incretin-Based Drugs and Adverse Pancreatic Events: Almost a Decade Later and Uncertainty Remains
Laurent Azoulay

Diabetes Care 2015 Jun; 38 (6): 951-953. https://doi.org/10.2337/dc15-0347

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Kelly West Award Lecture

Open Access
Progressive Renal Decline: The New Paradigm of Diabetic Nephropathy in Type 1 Diabetes
Andrzej S. Krolewski

Diabetes Care 2015 Jun; 38 (6): 954-962. https://doi.org/10.2337/dc15-0184

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Profiles in Progress

Open Access
James R. Gavin III, MD, PhD—A Humble and Remarkable Trailblazer, Scientist, Advocate, Mentor, and Educator for Diabetes
Kwame Osei and Sherita Hill Golden

Diabetes Care 2015 Jun; 38 (6): 963-967. https://doi.org/10.2337/dc14-3035

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Type 1 Diabetes at a Crossroads

Open Access
Type 1 Diabetes at a Crossroads!
William T. Cefalu, William V. Tamborlane and Jay S. Skyler

Diabetes Care 2015 Jun; 38 (6): 968-970. https://doi.org/10.2337/dc15-0615

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Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry
Kellee M. Miller, Nicole C. Foster, Roy W. Beck, Richard M. Bergenstal, Stephanie N. DuBose, Linda A. DiMeglio, David M. Maahs and William V. Tamborlane

Diabetes Care 2015 Jun; 38 (6): 971-978. https://doi.org/10.2337/dc15-0078

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Current Concepts on the Pathogenesis of Type 1 Diabetes—Considerations for Attempts to Prevent and Reverse the Disease
Mark A. Atkinson, Matthias von Herrath, Alvin C. Powers and Michael Clare-Salzler

Diabetes Care 2015 Jun; 38 (6): 979-988. https://doi.org/10.2337/dc15-0144

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Open Access
Predicting Type 1 Diabetes Using Biomarkers
Ezio Bonifacio

Diabetes Care 2015 Jun; 38 (6): 989-996. https://doi.org/10.2337/dc15-0101

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Prevention and Reversal of Type 1 Diabetes—Past Challenges and Future Opportunities
Jay S. Skyler

Diabetes Care 2015 Jun; 38 (6): 997-1007. https://doi.org/10.2337/dc15-0349

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Impact of Fat, Protein, and Glycemic Index on Postprandial Glucose Control in Type 1 Diabetes: Implications for Intensive Diabetes Management in the Continuous Glucose Monitoring Era
Kirstine J. Bell, Carmel E. Smart, Garry M. Steil, Jennie C. Brand-Miller, Bruce King and Howard A. Wolpert

Diabetes Care 2015 Jun; 38 (6): 1008-1015. https://doi.org/10.2337/dc15-0100

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Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia
Pratik Choudhary, Michael R. Rickels, Peter A. Senior, Marie-Christine Vantyghem, Paola Maffi, Thomas W. Kay, Bart Keymeulen, Nobuya Inagaki, Frantisek Saudek, Roger Lehmann and Bernhard J. Hering

Diabetes Care 2015 Jun; 38 (6): 1016-1029. https://doi.org/10.2337/dc15-0090

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Islet Transplantation for Type 1 Diabetes, 2015: What Have We Learned From Alloislet and Autoislet Successes?
R. Paul Robertson

Diabetes Care 2015 Jun; 38 (6): 1030-1035. https://doi.org/10.2337/dc15-0079

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Pathway to Artificial Pancreas Systems Revisited: Moving Downstream
Aaron Kowalski

Diabetes Care 2015 Jun; 38 (6): 1036-1043. https://doi.org/10.2337/dc15-0364

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Clinical Care/Education/Nutrition/Psychosocial Research

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Selective Insulin Resistance in Homeostatic and Cognitive Control Brain Areas in Overweight and Obese Adults
Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche and Hubert Preissl

Diabetes Care 2015 Jun; 38 (6): 1044-1050. https://doi.org/10.2337/dc14-2319

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Comparison of Glycemic and Metabolic Control in Youth With Type 1 Diabetes With and Without Antipsychotic Medication: Analysis From the Nationwide German/Austrian Diabetes Survey (DPV)
Angela Galler, Esther Bollow, Michael Meusers, Bela Bartus, Andrea Näke, Holger Haberland, Edith Schober and Reinhard W. Holl

Diabetes Care 2015 Jun; 38 (6): 1051-1057. https://doi.org/10.2337/dc14-2538

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Open Access
Is There a Link Between Liraglutide and Pancreatitis? A Post Hoc Review of Pooled and Patient-Level Data From Completed Liraglutide Type 2 Diabetes Clinical Trials
Troels M. Jensen, Kishore Saha and William M. Steinberg

Diabetes Care 2015 Jun; 38 (6): 1058-1066. https://doi.org/10.2337/dc13-1210

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Epidemiology/Health Services Research

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The Hemoglobin Glycation Index Identifies Subpopulations With Harms or Benefits From Intensive Treatment in the ACCORD Trial
James M. Hempe, Shuqian Liu, Leann Myers, Robert J. McCarter, John B. Buse and Vivian Fonseca

Diabetes Care 2015 Jun; 38 (6): 1067-1074. https://doi.org/10.2337/dc14-1844

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Cardiorespiratory Fitness and Incident Diabetes: The FIT (Henry Ford ExercIse Testing) Project
Stephen P. Juraschek, Michael J. Blaha, Roger S. Blumenthal, Clinton Brawner, Waqas Qureshi, Steven J. Keteyian, John Schairer, Jonathan K. Ehrman and Mouaz H. Al-Mallah

Diabetes Care 2015 Jun; 38 (6): 1075-1081. https://doi.org/10.2337/dc14-2714

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Relations Between Subclinical Disease Markers and Type 2 Diabetes, Metabolic Syndrome, and Incident Cardiovascular Disease: The Jackson Heart Study
Vanessa Xanthakis, Jung Hye Sung, Tandaw E. Samdarshi, Alethea N. Hill, Solomon K. Musani, Mario Sims, Kamel A. Ghraibeh, Philip R. Liebson, Herman A. Taylor, Ramachandran S. Vasan and Ervin R. Fox

Diabetes Care 2015 Jun; 38 (6): 1082-1088. https://doi.org/10.2337/dc14-2460

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Incretin-Based Therapy and Risk of Acute Pancreatitis: A Nationwide Population-Based Case-Control Study
Reimar Wernich Thomsen, Lars Pedersen, Niels Møller, Johnny Kahlert, Henning Beck-Nielsen and Henrik Toft Sørensen

Diabetes Care 2015 Jun; 38 (6): 1089-1098. https://doi.org/10.2337/dc13-2983

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Circulating and Dietary Trans Fatty Acids and Incident Type 2 Diabetes in Older Adults: The Cardiovascular Health Study
Qianyi Wang, Fumiaki Imamura, Wenjie Ma, Molin Wang, Rozenn N. Lemaitre, Irena B. King, Xiaoling Song, Mary L. Biggs, Joseph A. Delaney, Kenneth J. Mukamal, Luc Djousse, David S. Siscovick and Dariush Mozaffarian

Diabetes Care 2015 Jun; 38 (6): 1099-1107. https://doi.org/10.2337/dc14-2101

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Pathophysiology/Complications

Open Access
Effects of Acute Hypoglycemia on Working Memory and Language Processing in Adults With and Without Type 1 Diabetes
Kate V. Allen, Martin J. Pickering, Nicola N. Zammitt, Robert J. Hartsuiker, Matthew J. Traxler, Brian M. Frier and Ian J. Deary

Diabetes Care 2015 Jun; 38 (6): 1108-1115. https://doi.org/10.2337/dc14-1657

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Diabetic Peripheral Neuropathy Compromises Balance During Daily Activities
Steven J. Brown, Joseph C. Handsaker, Frank L. Bowling, Andrew J.M. Boulton and Neil D. Reeves

Diabetes Care 2015 Jun; 38 (6): 1116-1122. https://doi.org/10.2337/dc14-1982

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Hyperglycemia Potentiates the Slowing of Gastric Emptying Induced by Exogenous GLP-1
Mark P. Plummer, Karen L. Jones, Caroline E. Cousins, Laurence G. Trahair, Juris J. Meier, Marianne J. Chapman, Michael Horowitz and Adam M. Deane

Diabetes Care 2015 Jun; 38 (6): 1123-1129. https://doi.org/10.2337/dc14-3091

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Kidney Injury Molecule-1 and the Loss of Kidney Function in Diabetic Nephropathy: A Likely Causal Link in Patients With Type 1 Diabetes
Nicolae M. Panduru, Niina Sandholm, Carol Forsblom, Markku Saraheimo, Emma H. Dahlström, Lena M. Thorn, Daniel Gordin, Nina Tolonen, Johan Wadén, Valma Harjutsalo, Angelika Bierhaus, Per M. Humpert and Per-Henrik Groop

Diabetes Care 2015 Jun; 38 (6): 1130-1137. https://doi.org/10.2337/dc14-2330

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Small Nerve Fiber Quantification in the Diagnosis of Diabetic Sensorimotor Polyneuropathy: Comparing Corneal Confocal Microscopy With Intraepidermal Nerve Fiber Density
Xin Chen, Jim Graham, Mohammad A. Dabbah, Ioannis N. Petropoulos, Georgios Ponirakis, Omar Asghar, Uazman Alam, Andrew Marshall, Hassan Fadavi, Maryam Ferdousi, Shazli Azmi, Mitra Tavakoli, Nathan Efron, Maria Jeziorska and Rayaz A. Malik

Diabetes Care 2015 Jun; 38 (6): 1138-1144. https://doi.org/10.2337/dc14-2422

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Cardiovascular and Metabolic Risk

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Efficacy and Safety of Saxagliptin in Older Participants in the SAVOR-TIMI 53 Trial
Lawrence A. Leiter, Hwee Teoh, Eugene Braunwald, Ofri Mosenzon, Avivit Cahn, K.M. Prasanna Kumar, Alena Smahelova, Boaz Hirshberg, Christina Stahre, Robert Frederich, Francois Bonnici, Benjamin M. Scirica, Deepak L. Bhatt and Itamar Raz

Diabetes Care 2015 Jun; 38 (6): 1145-1153. https://doi.org/10.2337/dc14-2868

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Changes in Gene Expression in Responders and Nonresponders to a Low-Intensity Walking Intervention
Megan E. Osler, Tomas Fritz, Kenneth Caidahl, Anna Krook, Juleen R. Zierath and Harriet Wallberg-Henriksson

Diabetes Care 2015 Jun; 38 (6): 1154-1160. https://doi.org/10.2337/dc14-2606

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Review

Open Access
Weight Management in Type 2 Diabetes: Current and Emerging Approaches to Treatment
Luc Van Gaal and André Scheen

Diabetes Care 2015 Jun; 38 (6): 1161-1172. https://doi.org/10.2337/dc14-1630

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Errata

Open Access
Erratum. Combination of Empagliflozin and Linagliptin as Second-Line Therapy in Subjects With Type 2 Diabetes Inadequately Controlled on Metformin. Diabetes Care 2015;38:384–393
Ralph A. DeFronzo, Andrew Lewin, Sanjay Patel, Dacheng Liu, Renee Kaste, Hans J. Woerle and Uli C. Broedl

Diabetes Care 2015 Jun; 38 (6): 1173. https://doi.org/10.2337/dc15-er06

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Erratum. Initial Combination of Empagliflozin and Linagliptin in Subjects With Type 2 Diabetes. Diabetes Care 2015;38:394–402
Andrew Lewin, Ralph A. DeFronzo, Sanjay Patel, Dacheng Liu, Renee Kaste, Hans J. Woerle and Uli C. Broedl

Diabetes Care 2015 Jun; 38 (6): 1173. https://doi.org/10.2337/dc15-er06a

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Issues and Events

Open Access
Issues and Events
Diabetes Care 2015 Jun; 38 (6): 1174. https://doi.org/10.2337/dc15-ie06

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e-Letters

Observations
- Open Access
  Trends and Characteristics of Self-reported Case Presentation of Diabetes Diagnosis Among Youth From 2002 to 2010: Findings From the SEARCH for Diabetes in Youth Study
  Sharon H. Saydah, Giuseppina Imperatore, Leora Henkin, Ralph D’Agostino, Jasmin Divers, Elizabeth J. Mayer-Davis, Dana Dabelea, Georgeanna Klingensmith, Catherine Pihoker and Jean M. Lawrence
  
  Diabetes Care 2015 Jun; 38 (6): e84-e85. https://doi.org/10.2337/dc15-0157
  
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- Open Access
  Role of Noninsulin Therapies Alone or in Combination in Chromosome 6q24-Related Transient Neonatal Diabetes: Sulfonylurea Improves but Does Not Always Normalize Insulin Secretion
  David Carmody, Flavius A. Beca, Charles D. Bell, Jessica L. Hwang, Jazzmyne T. Dickens, Nancy A. Devine, Deborah J.G. Mackay, I. Karen Temple, Lisa R. Hays, Rochelle N. Naylor, Louis H. Philipson and Siri Atma W. Greeley
  
  Diabetes Care 2015 Jun; 38 (6): e86-e87. https://doi.org/10.2337/dc14-3056
  
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Comments and Responses
- Open Access
  Comment on Udell et al. Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial. Diabetes Care 2015;38:696–705
  Sanjay Kalra, Yashdeep Gupta, Manash P. Baruah and Anu Gupta
  
  Diabetes Care 2015 Jun; 38 (6): e88-e89. https://doi.org/10.2337/dc15-0006
  
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- Open Access
  Comment on Hsu et al. BMI Cut Points to Identify At-Risk Asian Americans for Type 2 Diabetes Screening. Diabetes Care 2015;38:150–158
  Stella S. Yi, Nadia Islam and Chau Trinh-Shevrin
  
  Diabetes Care 2015 Jun; 38 (6): e90. https://doi.org/10.2337/dc15-0470
  
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- Open Access
  Comment on Khunti et al. Hypoglycemia and Risk of Cardiovascular Disease and All-Cause Mortality in Insulin-Treated People With Type 1 and Type 2 Diabetes: A Cohort Study. Diabetes Care 2015;38:316–322
  Marga Giménez, Antonio J. Amor, Carmen Quirós and Ignacio Conget
  
  Diabetes Care 2015 Jun; 38 (6): e91. https://doi.org/10.2337/dc15-0271
  
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- Open Access
  Comment on Hughes et al. An Early Pregnancy HbA_1c ≥5.9% (41 mmol/mol) Is Optimal for Detecting Diabetes and Identifies Women at Increased Risk of Adverse Pregnancy Outcomes. Diabetes Care 2014;37:2953–2959
  H. Bryan Anderson, Shadi Rezai, Anuradha Setlur and Cassandra E. Henderson
  
  Diabetes Care 2015 Jun; 38 (6): e92. https://doi.org/10.2337/dc14-2962
  
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- Open Access
  Response to Comment on Hughes et al. An Early Pregnancy HbA_1c ≥5.9% (41 mmol/mol) Is Optimal for Detecting Diabetes and Identifies Women at Increased Risk of Adverse Pregnancy Outcomes. Diabetes Care 2014;37:2953–2959
  Ruth C.E. Hughes, M. Peter Moore, Joanna E. Gullam and Janet Rowan
  
  Diabetes Care 2015 Jun; 38 (6): e93. https://doi.org/10.2337/dc15-0401
  
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- Open Access
  Comment on Genuth. Should Sulfonylureas Remain an Acceptable First-Line Add-on to Metformin Therapy in Patients With Type 2 Diabetes? No, It’s Time to Move On! Diabetes Care 2015;38:170–175
  Dennis Schrijnders, Sebastiaan T. Houweling and Gijs W.D. Landman
  
  Diabetes Care 2015 Jun; 38 (6): e94. https://doi.org/10.2337/dc15-0293
  
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- Open Access
  Response to Comment on Genuth. Should Sulfonylureas Remain an Acceptable First-Line Add-on to Metformin Therapy in Patients With Type 2 Diabetes? No, It’s Time to Move On! Diabetes Care 2015;38:170–175
  Saul Genuth
  
  Diabetes Care 2015 Jun; 38 (6): e95. https://doi.org/10.2337/dc15-0519
  
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Table of Contents

In This Issue

Editor’s Note

Commentaries

Kelly West Award Lecture

Profiles in Progress

Type 1 Diabetes at a Crossroads

Clinical Care/Education/Nutrition/Psychosocial Research

Epidemiology/Health Services Research

Pathophysiology/Complications

Cardiovascular and Metabolic Risk

Review

Errata

Issues and Events

e-Letters

Observations

Comments and Responses

In this Issue

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