Diabetes Care: 39 (7)

July 01 2016; volume 39 issue 7

In This Issue

Open Access
In This Issue of Diabetes Care
Diabetes Care 2016 Jul; 39 (7): 1067-1068. https://doi.org/10.2337/dc16-ti07

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Editor’s Commentary

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Diabetes Care: “Lagniappe” and “Seeing Is Believing”!
William T. Cefalu, Andrew J.M. Boulton, William V. Tamborlane, Robert G. Moses, Derek LeRoith, Eddie L. Greene, Frank B. Hu, George Bakris, Judith Wylie-Rosett, Julio Rosenstock, Katie Weinger, Lawrence Blonde, Mary de Groot, Stephen S. Rich, David D’Alessio, Matthew C. Riddle and Lyn Reynolds

Diabetes Care 2016 Jul; 39 (7): 1069-1071. https://doi.org/10.2337/dc16-0891

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Commentaries

Open Access
Islet Transplantation for Hypoglycemia Unawareness/Severe Hypoglycemia: Caveat Emptor
David M. Harlan

Diabetes Care 2016 Jul; 39 (7): 1072-1074. https://doi.org/10.2337/dci16-0008

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Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists
Mackenzie J. Pearson, Roger H. Unger and William L. Holland

Diabetes Care 2016 Jul; 39 (7): 1075-1077. https://doi.org/10.2337/dci15-0033

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Open Access
Reevaluation of CMS’ Competitive Bidding Program
Desmond Schatz and William T. Cefalu

Diabetes Care 2016 Jul; 39 (7): 1078-1079. https://doi.org/10.2337/dc16-0903

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Diabetes Care Symposium

This section features six articles from the Diabetes Care Symposium “Novel Clinical Strategies in the Management of Diabetes,” held in conjunction with the ADA's 76th Scientific Sessions in New Orleans, 10–14 June 2016.
- Open Access
  NIH Precision Medicine Initiative: Implications for Diabetes Research
  Judith E. Fradkin, Mary C. Hanlon and Griffin P. Rodgers
  
  Diabetes Care 2016 Jul; 39 (7): 1080-1084. https://doi.org/10.2337/dc16-0541
  
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- Open Access
  Precision Medicine in Diabetes: Is It Time?
  Jose C. Florez
  
  Diabetes Care 2016 Jul; 39 (7): 1085-1088. https://doi.org/10.2337/dc16-0586
  
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- Open Access
  Persistent Effects of Intensive Glycemic Control on Retinopathy in Type 2 Diabetes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Follow-On Study
  The Action to Control Cardiovascular Risk in Diabetes Follow-On (ACCORDION) Eye Study Group and the Action to Control Cardiovascular Risk in Diabetes Follow-On (ACCORDION) Study Group
  
  Diabetes Care 2016 Jul; 39 (7): 1089-1100. https://doi.org/10.2337/dc16-0024
  
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- Open Access
  Type 2 Diabetes Remission Rates After Laparoscopic Gastric Bypass and Gastric Banding: Results of the Longitudinal Assessment of Bariatric Surgery Study
  Jonathan Q. Purnell, Faith Selzer, Abdus S. Wahed, John Pender, Walter Pories, Alfons Pomp, Greg Dakin, James Mitchell, Luis Garcia, Myrlene A. Staten, Carol McCloskey, David E. Cummings, David R. Flum, Anita Courcoulas and Bruce M. Wolfe
  
  Diabetes Care 2016 Jul; 39 (7): 1101-1107. https://doi.org/10.2337/dc15-2138
  
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- Open Access
  CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis
  Ele Ferrannini, Michael Mark and Eric Mayoux
  
  Diabetes Care 2016 Jul; 39 (7): 1108-1114. https://doi.org/10.2337/dc16-0330
  
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- Open Access
  Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis
  Sunder Mudaliar, Sindura Alloju and Robert R. Henry
  
  Diabetes Care 2016 Jul; 39 (7): 1115-1122. https://doi.org/10.2337/dc16-0542
  
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The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

Open Access
The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes
Boris Kovatchev, William V. Tamborlane, William T. Cefalu and Claudio Cobelli

Diabetes Care 2016 Jul; 39 (7): 1123-1126. https://doi.org/10.2337/dc16-0824

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Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide
Jennifer L. Sherr, Neha S. Patel, Camille I. Michaud, Miladys M. Palau-Collazo, Michelle A. Van Name, William V. Tamborlane, Eda Cengiz, Lori R. Carria, Eileen M. Tichy and Stuart A. Weinzimer

Diabetes Care 2016 Jul; 39 (7): 1127-1134. https://doi.org/10.2337/dc16-0089

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Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas
Jordan E. Pinsker, Joon Bok Lee, Eyal Dassau, Dale E. Seborg, Paige K. Bradley, Ravi Gondhalekar, Wendy C. Bevier, Lauren Huyett, Howard C. Zisser and Francis J. Doyle

Diabetes Care 2016 Jul; 39 (7): 1135-1142. https://doi.org/10.2337/dc15-2344

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Multinational Home Use of Closed-Loop Control Is Safe and Effective
Stacey M. Anderson, Dan Raghinaru, Jordan E. Pinsker, Federico Boscari, Eric Renard, Bruce A. Buckingham, Revital Nimri, Francis J. Doyle, Sue A. Brown, Patrick Keith-Hynes, Marc D. Breton, Daniel Chernavvsky, Wendy C. Bevier, Paige K. Bradley, Daniela Bruttomesso, Simone Del Favero, Roberta Calore, Claudio Cobelli, Angelo Avogaro, Anne Farret, Jerome Place, Trang T. Ly, Satya Shanmugham, Moshe Phillip, Eyal Dassau, Isuru S. Dasanayake, Craig Kollman, John W. Lum, Roy W. Beck and Boris Kovatchev

Diabetes Care 2016 Jul; 39 (7): 1143-1150. https://doi.org/10.2337/dc15-2468

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Day-and-Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home
Eric Renard, Anne Farret, Jort Kropff, Daniela Bruttomesso, Mirko Messori, Jerome Place, Roberto Visentin, Roberta Calore, Chiara Toffanin, Federico Di Palma, Giordano Lanzola, Paolo Magni, Federico Boscari, Silvia Galasso, Angelo Avogaro, Patrick Keith-Hynes, Boris Kovatchev, Simone Del Favero, Claudio Cobelli, Lalo Magni and J. Hans DeVries

Diabetes Care 2016 Jul; 39 (7): 1151-1160. https://doi.org/10.2337/dc16-0008

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Design Considerations for Artificial Pancreas Pivotal Studies
Steven J. Russell and Roy W. Beck

Diabetes Care 2016 Jul; 39 (7): 1161-1167. https://doi.org/10.2337/dc15-2449

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Day-and-Night Hybrid Closed-Loop Insulin Delivery in Adolescents With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial
Martin Tauschmann, Janet M. Allen, Malgorzata E. Wilinska, Hood Thabit, Zoë Stewart, Peiyao Cheng, Craig Kollman, Carlo L. Acerini, David B. Dunger and Roman Hovorka

Diabetes Care 2016 Jul; 39 (7): 1168-1174. https://doi.org/10.2337/dc15-2078

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Open Access
Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report
David M. Maahs, Bruce A. Buckingham, Jessica R. Castle, Ali Cinar, Edward R. Damiano, Eyal Dassau, J. Hans DeVries, Francis J. Doyle, Steven C. Griffen, Ahmad Haidar, Lutz Heinemann, Roman Hovorka, Timothy W. Jones, Craig Kollman, Boris Kovatchev, Brian L. Levy, Revital Nimri, David N. O’Neal, Moshe Philip, Eric Renard, Steven J. Russell, Stuart A. Weinzimer, Howard Zisser and John W. Lum

Diabetes Care 2016 Jul; 39 (7): 1175-1179. https://doi.org/10.2337/dc15-2716

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Open Access
Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe
Simone Del Favero, Federico Boscari, Mirko Messori, Ivana Rabbone, Riccardo Bonfanti, Alberto Sabbion, Dario Iafusco, Riccardo Schiaffini, Roberto Visentin, Roberta Calore, Yenny Leal Moncada, Silvia Galasso, Alfonso Galderisi, Valeria Vallone, Federico Di Palma, Eleonora Losiouk, Giordano Lanzola, Davide Tinti, Andrea Rigamonti, Marco Marigliano, Angela Zanfardino, Novella Rapini, Angelo Avogaro, Daniel Chernavvsky, Lalo Magni, Claudio Cobelli and Daniela Bruttomesso

Diabetes Care 2016 Jul; 39 (7): 1180-1185. https://doi.org/10.2337/dc15-2815

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Diabetes Care Expert Forum

Open Access
Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum
William T. Cefalu, John B. Buse, Jaakko Tuomilehto, G. Alexander Fleming, Ele Ferrannini, Hertzel C. Gerstein, Peter H. Bennett, Ambady Ramachandran, Itamar Raz, Julio Rosenstock and Steven E. Kahn

Diabetes Care 2016 Jul; 39 (7): 1186-1201. https://doi.org/10.2337/dc16-0873

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Clinical Care/Education/Nutrition/Psychosocial Research

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Cognitive Dysfunction: Part and Parcel of the Diabetic Foot
Rachel Natovich, Talma Kushnir, Ilana Harman-Boehm, Daniella Margalit, Itzhak Siev-Ner, Daniel Tsalichin, Ilia Volkov, Shmuel Giveon, Deborah Rubin-Asher and Tali Cukierman-Yaffe

Diabetes Care 2016 Jul; 39 (7): 1202-1207. https://doi.org/10.2337/dc15-2838

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Epidemiology/Health Services Research

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Relative Contributions of Socioeconomic, Local Environmental, Psychosocial, Lifestyle/Behavioral, Biophysiological, and Ancestral Factors to Racial/Ethnic Disparities in Type 2 Diabetes
Rebecca S. Piccolo, S.V. Subramanian, Neil Pearce, Jose C. Florez and John B. McKinlay

Diabetes Care 2016 Jul; 39 (7): 1208-1217. https://doi.org/10.2337/dc15-2255

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Seasonal Changes in the Prevalence of Gestational Diabetes Mellitus
Robert G. Moses, Veronica C.K. Wong, Kelly Lambert, Gary J. Morris and Fernando San Gil

Diabetes Care 2016 Jul; 39 (7): 1218-1221. https://doi.org/10.2337/dc16-0451

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Disability-Free Life-Years Lost Among Adults Aged ≥50 Years With and Without Diabetes
Barbara H. Bardenheier, Ji Lin, Xiaohui Zhuo, Mohammed K. Ali, Theodore J. Thompson, Yiling J. Cheng and Edward W. Gregg

Diabetes Care 2016 Jul; 39 (7): 1222-1229. https://doi.org/10.2337/dc15-1095

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Emerging Technologies and Therapeutics

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Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia
Bernhard J. Hering, William R. Clarke, Nancy D. Bridges, Thomas L. Eggerman, Rodolfo Alejandro, Melena D. Bellin, Kathryn Chaloner, Christine W. Czarniecki, Julia S. Goldstein, Lawrence G. Hunsicker, Dixon B. Kaufman, Olle Korsgren, Christian P. Larsen, Xunrong Luo, James F. Markmann, Ali Naji, Jose Oberholzer, Andrew M. Posselt, Michael R. Rickels, Camillo Ricordi, Mark A. Robien, Peter A. Senior, A.M. James Shapiro, Peter G. Stock and Nicole A. Turgeon

Diabetes Care 2016 Jul; 39 (7): 1230-1240. https://doi.org/10.2337/dc15-1988

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Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies
Christof M. Kazda, Ying Ding, Ronan P. Kelly, Parag Garhyan, Chunxue Shi, Chay Ngee Lim, Haoda Fu, David E. Watson, Andrew J. Lewin, William H. Landschulz, Mark A. Deeg, David E. Moller and Thomas A. Hardy

Diabetes Care 2016 Jul; 39 (7): 1241-1249. https://doi.org/10.2337/dc15-1643

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Pathophysiology/Complications

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Maternal Serum Prolactin and Prediction of Postpartum β-Cell Function and Risk of Prediabetes/Diabetes
Ravi Retnakaran, Chang Ye, Caroline K. Kramer, Philip W. Connelly, Anthony J. Hanley, Mathew Sermer and Bernard Zinman

Diabetes Care 2016 Jul; 39 (7): 1250-1258. https://doi.org/10.2337/dc16-0043

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Cardiovascular and Metabolic Risk

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Dynamic Changes in Renal Function Are Associated With Major Cardiovascular Events in Patients With Type 2 Diabetes
Stéphanie Ragot, Pierre-Jean Saulnier, Gilberto Velho, Elise Gand, Astrid de Hauteclocque, Yousri Slaoui, Louis Potier, Philippe Sosner, Jean-Michel Halimi, Philippe Zaoui, Vincent Rigalleau, Frederic Fumeron, Ronan Roussel, Michel Marre and Samy Hadjadj

Diabetes Care 2016 Jul; 39 (7): 1259-1266. https://doi.org/10.2337/dc15-2607

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Cardiovascular Mortality in Patients With Type 2 Diabetes and Recent Acute Coronary Syndromes From the EXAMINE Trial
William B. White, Stuart Kupfer, Faiez Zannad, Cyrus R. Mehta, Craig A. Wilson, Lanyu Lei, George L. Bakris, Steven E. Nissen, William C. Cushman, Simon R. Heller, Richard M. Bergenstal, Penny R. Fleck and Christopher P. Cannon

Diabetes Care 2016 Jul; 39 (7): 1267-1273. https://doi.org/10.2337/dc16-0303

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Meta-analysis

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Prognostic Value of Coronary Computed Tomography Angiography in Patients With Diabetes: A Meta-analysis
Csilla Celeng, Pál Maurovich-Horvat, Brian B. Ghoshhajra, Béla Merkely, Tim Leiner and Richard A.P. Takx

Diabetes Care 2016 Jul; 39 (7): 1274-1280. https://doi.org/10.2337/dc16-0281

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Point-Counterpoint

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Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety!
Kamyar Kalantar-Zadeh and Csaba P. Kovesdy

Diabetes Care 2016 Jul; 39 (7): 1281-1286. https://doi.org/10.2337/dc15-2327

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Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What’s the Fuss?
George L. Bakris and Mark E. Molitch

Diabetes Care 2016 Jul; 39 (7): 1287-1291. https://doi.org/10.2337/dc15-2534

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Clinical Images in Diabetes

Open Access
Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets
Laura M. Jacobsen, Mark A. Atkinson, Martha Campbell-Thompson and Desmond A. Schatz

Diabetes Care 2016 Jul; 39 (7): 1292-1294. https://doi.org/10.2337/dc16-0737

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Issues and Events

Open Access
Issues and Events
Diabetes Care 2016 Jul; 39 (7): 1295. https://doi.org/10.2337/dc16-ie07

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e-Letters

Observations
- Open Access
  IADPSG and WHO 2013 Gestational Diabetes Mellitus Criteria Identify Obese Women With Marked Insulin Resistance in Early Pregnancy
  Jürgen Harreiter, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M. Adelantado, Roland Devlieger, Andre van Assche, Sander Galjaard, Peter Damm, Elisabeth R. Mathiesen, Dorte M. Jensen, Lise Lotte T. Andersen, Fidelma Dunne, Annunziata Lapolla, Maria G. Dalfra, Alessandra Bertolotto, Urzula Mantaj, Ewa Wender-Ozegowska, Agnieszka Zawiejska, David Hill, Judith G.M. Jelsma, Frank J. Snoek, Christof Worda, Dagmar Bancher-Todesca, Mireille N.M. van Poppel and Alexandra Kautzky-Willer
  
  Diabetes Care 2016 Jul; 39 (7): e90-e92. https://doi.org/10.2337/dc16-0200
  
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- Open Access
  HbA_1c-Based Classification Reveals Epidemic of Diabetes and Prediabetes in Vietnam
  Lan T. Ho-Pham, Thanh T. Do, Lesley V. Campbell and Tuan V. Nguyen
  
  Diabetes Care 2016 Jul; 39 (7): e93-e94. https://doi.org/10.2337/dc16-0654
  
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- Open Access
  Nocturnal Hypoglycemia and Physical Activity in Children With Diabetes: New Insights by Continuous Glucose Monitoring and Accelerometry
  Sara Bachmann, Melanie Hess, Eva Martin-Diener, Kris Denhaerynck and Urs Zumsteg
  
  Diabetes Care 2016 Jul; 39 (7): e95-e96. https://doi.org/10.2337/dc16-0411
  
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- Open Access
  Exhaled Breath Isoprene Rises During Hypoglycemia in Type 1 Diabetes
  Sankalpa Neupane, Robert Peverall, Graham Richmond, Tom P.J. Blaikie, David Taylor, Gus Hancock and Mark L. Evans
  
  Diabetes Care 2016 Jul; 39 (7): e97-e98. https://doi.org/10.2337/dc16-0461
  
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- Open Access
  Evaluating the Quality of Comprehensive Cardiometabolic Care for Patients With Type 2 Diabetes in the U.S.: The Diabetes Collaborative Registry
  Suzanne V. Arnold, Silvio E. Inzucchi, Darren K. McGuire, Sanjeev N. Mehta, Abhinav Goyal, Laurence S. Sperling, Thomas M. Maddox, Daniel Einhorn, Nathan D. Wong, Robert E. Ratner, Niklas Hammar, Peter Fenici, John J. Sheehan, Jennifer L. Wong and Mikhail Kosiborod
  
  Diabetes Care 2016 Jul; 39 (7): e99-e101. https://doi.org/10.2337/dc16-0585
  
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Comments and Responses
- Open Access
  Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455–464
  Maria Ida Maiorino, Giuseppe Bellastella, Dario Giugliano and Katherine Esposito
  
  Diabetes Care 2016 Jul; 39 (7): e102-e103. https://doi.org/10.2337/dc16-0475
  
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- Open Access
  Response to Comment on Mita et al. Sitagliptin Attenuates the Progression of Carotid Intima-Media Thickening in Insulin-Treated Patients With Type 2 Diabetes: The Sitagliptin Preventive Study of Intima-Media Thickness Evaluation (SPIKE): A Randomized Controlled Trial. Diabetes Care 2016;39:455–464
  Tomoya Mita, Naoto Katakami, Iichiro Shimomura and Hirotaka Watada
  
  Diabetes Care 2016 Jul; 39 (7): e104-e105. https://doi.org/10.2337/dci16-0012
  
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Table of Contents

In This Issue

Editor’s Commentary

Commentaries

Diabetes Care Symposium

This section features six articles from the Diabetes Care Symposium “Novel Clinical Strategies in the Management of Diabetes,” held in conjunction with the ADA's 76th Scientific Sessions in New Orleans, 10–14 June 2016.

The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

Diabetes Care Expert Forum

Clinical Care/Education/Nutrition/Psychosocial Research

Epidemiology/Health Services Research

Emerging Technologies and Therapeutics

Pathophysiology/Complications

Cardiovascular and Metabolic Risk

Meta-analysis

Point-Counterpoint

Clinical Images in Diabetes

Issues and Events

e-Letters

Observations

Comments and Responses

In this Issue

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