Glucose Measurements at Various Time Points During the OGTT and Their Role in Capturing Glucose Response Patterns
- Adam Hulman1,2,3⇑,
- Róbert Wagner4,5,6,
- Dorte Vistisen7,
- Kristine Færch7,
- Beverley Balkau8,9,10,
- Melania Manco11,
- Alain Golay12,
- Hans-Ulrich Häring4,5,6,
- Martin Heni4,5,6,
- Andreas Fritsche4,5,6 and
- Daniel R. Witte2,3
- 1Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
- 2Aarhus University, Aarhus, Denmark
- 3Danish Diabetes Academy, Odense, Denmark
- 4Division of Endocrinology, Diabetology, Nephrology, Vascular Disease, and Clinical Chemistry, Department of Internal Medicine IV, University Hospital of Tübingen, Tübingen, Germany
- 5Institute for Diabetes Research and Metabolic Diseases, Helmholtz Centre Munich, University of Tübingen, Tübingen, Germany
- 6German Center for Diabetes Research (DZD), Neuherberg, Germany
- 7Steno Diabetes Center Copenhagen, Gentofte, Denmark
- 8Centre for Research in Epidemiology and Population Health, University Paris-South, Paris, France
- 9Faculty of Medicine, University of Versailles-St. Quentin, Versailles, France
- 10INSERM U1018, University Paris-Saclay, Villejuif, France
- 11Research Unit for Multi-factorial Diseases, Obesity and Diabetes, Istituto di Ricovero e Cura a Carattere Scientifico, Bambino Gesù Children's Hospital,Rome, Italy
- 12Division of Therapeutic Education for Chronic Diseases, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland
- Corresponding author: Adam Hulman, adam.hulman{at}ph.au.dk
Intermediate time points during the oral glucose tolerance test (OGTT) have received more attention recently (1), with some researchers even suggesting to use 1-h glucose when screening for prediabetes (2). We demonstrated that characterization of glucose response patterns from OGTTs with five time points provides useful insights into the heterogeneity of type 2 diabetes development (3). Although such analyses are feasible in small pathophysiological investigations, they are not common in large epidemiological studies where the number of glucose measurements during an OGTT is often limited. Therefore, we aimed to study how well different combinations of fewer than five time points during an OGTT approximate glucose response patterns based on five time points.
We analyzed data from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study, which we previously used to develop a glucose pattern classification model (3). The Tübingen Family Study (TUEF) cohort was used for external validation (4). Both studies included five-point OGTTs with glucose measurements at 0, 30, 60, 90, and 120 min. We excluded participants with self-reported diabetes or screen-detected diabetes (fasting plasma glucose ≥7.0 mmol/L or 2-h postload plasma glucose ≥11.1 mmol/L), participants taking glucose-lowering medication, and those with missing measurements at any of the five time points.
We previously identified four glucose …
In this Issue
