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e-Letters: Comments and Responses

Response to Comment on Kim et al. The Effect of a Smartphone-Based, Patient-Centered Diabetes Care System in Patients With Type 2 Diabetes: A Randomized, Controlled Trial for 24 Weeks. Diabetes Care 2019;42:3–9

  1. Eun Ky Kim1 and
  2. Young Min Cho2⇑
  1. 1International Healthcare Center, Seoul National University Hospital, Seoul, Korea
  2. 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
  1. Corresponding author: Young Min Cho, ymchomd{at}snu.ac.kr
Diabetes Care 2019 Jul; 42(7): e126-e126. https://doi.org/10.2337/dci19-0021
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We thank Huo et al. (1) for their interest in our study (2) on the effect of a smartphone-based, patient-centered diabetes care system (mDiabetes) in patients with type 2 diabetes. In our study, the efficacy of mDiabetes was examined in the full analysis set, which excluded participants who failed to meet inclusion/exclusion criteria or lacked any postrandomization data to evaluate the effect of mDiabetes on glucose control. With respect to the comment, we additionally analyzed the primary outcome in the classical intention-to-treat population using the last observation carried forward method. Among 191 randomly assigned patients, two patients withdrew their consent before the baseline laboratory test. Consequently, 189 patients (95 patients in the mDiabetes group and 94 patients in the control group) were included to the intention-to-treat set. The difference of the adjusted mean changes in HbA1c level was 0.39% (95% CI 0.16−0.62, P = 0.0002), which showed similar results with the full analysis set.

As Huo et al. (1) mentioned, the medication dose titration algorithm in our study was designed only for insulin. The comment is valuable, but we think that it would be very difficult to adjust the dose of oral drugs because we have to consider renal and hepatic function, drug–drug interaction, risk of hypoglycemia, and many other factors. It is conceivable that dose adjustment for sulfonylurea might be possible. However, the dose response is neither linear nor limitless with sulfonylurea when compared with insulin. Consequently, the automatic dose adjustment of oral antidiabetic medication would not be easy to implement with mDiabetes or other measures using smartphone applications.

We agree with the commenters' concern about imprudent overestimation of the effect of mobile health technology. However, based on the results of well-desinged studies, we think the future of this new therapeutic option is still viable.

Article Information

Funding. This work was funded by Health Connect Co.

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Footnotes

  • Clinical trial reg. no. NCT02451631, clinicaltrials.gov

  • © 2019 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

References

  1. ↵
    1. Huo X,
    2. Holman RR,
    3. Armitage J
    . Comment on Kim et al. The effect of a smartphone-based, patient-centered diabetes care system in patients with type 2 diabetes: a randomized, controlled trial for 24 weeks. Diabetes Care 2019;42:3–9 (Letter). Diabetes Care 2019;42:e125. DOI: 10.2337/dc19-0535
    OpenUrlFREE Full Text
  2. ↵
    1. Kim EK,
    2. Kwak SH,
    3. Jung HS, et al
    . The effect of a smartphone-based, patient-centered diabetes care system in patients with type 2 diabetes: a randomized, controlled trial for 24 weeks. Diabetes Care 2019;42:3–9
    OpenUrlAbstract/FREE Full Text
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Diabetes Care: 42 (7)

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July 2019, 42(7)
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Response to Comment on Kim et al. The Effect of a Smartphone-Based, Patient-Centered Diabetes Care System in Patients With Type 2 Diabetes: A Randomized, Controlled Trial for 24 Weeks. Diabetes Care 2019;42:3–9
Eun Ky Kim, Young Min Cho
Diabetes Care Jul 2019, 42 (7) e126; DOI: 10.2337/dci19-0021

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Response to Comment on Kim et al. The Effect of a Smartphone-Based, Patient-Centered Diabetes Care System in Patients With Type 2 Diabetes: A Randomized, Controlled Trial for 24 Weeks. Diabetes Care 2019;42:3–9
Eun Ky Kim, Young Min Cho
Diabetes Care Jul 2019, 42 (7) e126; DOI: 10.2337/dci19-0021
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