Skip to main content
  • More from ADA
    • Diabetes
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes Care

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • Special Article Collections
    • ADA Standards of Medical Care
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • Special Article Collections
    • ADA Standards of Medical Care
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • My Cart

Search

  • Advanced search
Diabetes Care
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • Special Article Collections
    • ADA Standards of Medical Care
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • Special Article Collections
    • ADA Standards of Medical Care
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Nonalcoholic Fatty Liver Disease in Diabetes

Economic and Clinical Burden of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes in the U.S.

  1. Zobair M. Younossi1,2⇑,
  2. Radhika P. Tampi1,
  3. Andrei Racila1,2,
  4. Ying Qiu3,
  5. Leah Burns3,
  6. Issah Younossi4 and
  7. Fatema Nader4
  1. 1Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA
  2. 2Center For Liver Diseases, Department of Medicine, Inova Fairfax Hospital, Falls Church, VA
  3. 3Worldwide Health Economics and Outcomes Research, Bristol-Myers Squibb, Princeton, NJ
  4. 4Center for Outcomes Research in Liver Disease, Washington, DC
  1. Corresponding author: Zobair M. Younossi, zobair.younossi{at}inova.org
Diabetes Care 2020 Feb; 43(2): 283-289. https://doi.org/10.2337/dc19-1113
PreviousNext
  • Article
  • Figures & Tables
  • Suppl Material
  • Info & Metrics
  • PDF
Loading

Abstract

OBJECTIVE Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) and is strongly associated with type 2 diabetes mellitus (T2DM). Patients with both T2DM and NASH have increased risk for adverse clinical outcomes, leading to higher risk for mortality and morbidity. We built a Markov model with 1-year cycles and 20-year horizon to estimate the economic burden of NASH with T2DM in the U.S.

RESEARCH DESIGN AND METHODS Cohort size was determined by population size, prevalence of T2DM, and prevalence and incidence of NASH in 2017. The model includes 10 health states—NAFL, NASH fibrosis stages F0 through F3, compensated and decompensated cirrhosis, hepatocellular carcinoma, 1 year post–liver transplant, and post–liver transplant—as well as liver-related, cardiovascular, and background mortality. Transition probabilities were calculated from meta-analyses and literature. Annual costs for NASH and T2DM were taken from literature and billing codes.

RESULTS We estimated that there were 18.2 million people in the U.S. living with T2DM and NAFLD, of which 6.4 million had NASH. Twenty-year costs for NAFLD in these patients were $55.8 billion. Over the next 20 years, NASH with T2DM will account for 65,000 transplants, 1.37 million cardiovascular-related deaths, and 812,000 liver-related deaths.

CONCLUSIONS This model predicts significant clinical and economic burden due to NASH with T2DM over the next 20 years. In fact, this burden may be greater since we assumed conservative inputs for our model and did not increase costs or the incidence of T2DM over time. It is highly likely that interventions reducing morbidity and mortality in NASH patients with T2DM could potentially reduce this projected clinical and economic burden.

Introduction

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis (>5%) in the absence of excessive alcohol consumption or other causes of fatty liver disease and chronic liver disease (1). NAFLD ranges from simple steatosis (NAFL), which has a low likelihood of progression to advanced liver disease, to nonalcoholic steatohepatitis (NASH), which has greater potential for progression. NAFLD is recognized as one of the most common causes of chronic liver disease in the U.S. and worldwide (1–3). NAFLD is highly prevalent in patients with components of metabolic syndrome (4,5). In fact, risk factors for NAFLD include visceral obesity, impaired insulin sensitivity, and type 2 diabetes mellitus (T2DM), as well as older age, male sex, and Hispanic ethnicity (4,6,7). The global prevalence of NAFLD is estimated to be 25.2%, and the prevalence of NASH is estimated at 1.5–6.45% in the general population (8,9). Patients with NASH are more likely to progress to advanced liver disease and die of liver-related causes, and all NAFLD patients, regardless of underlying liver pathology, are at risk for cardiovascular disease (10–13). In addition to clinical burden, NAFLD and NASH are associated with significant health care utilization (14–16).

Although the global prevalence of NAFLD in the general population is quite high, the prevalence is even greater in patients with T2DM, at 55.5% (95% CI 47.3–63.7) globally when diagnosed by ultrasound or proton MRS (1H-MRS) and 59.7% (95% CI 52.8–66.5) when diagnosed using ultrasound or aminotransferase levels (17,18). In the U.S., the prevalence of NAFLD among patients with T2DM was 51.8% (95% CI 31.3–71.6) when using ultrasound or 1H-MRS and 53.1% (95% CI 26.1–78.4) when using any diagnostic method. The prevalence of NASH among patients with T2DM was 37.3% (95% CI 24.7–50.0) when diagnosed via liver biopsy, and the prevalence of advanced fibrosis among biopsied patients with NAFLD and T2DM was 17.02% (95% CI 7.3–34.9) (17).

Additionally, the presence of T2DM in patients with NAFLD has been shown to adversely affect long-term outcomes. Patients with T2DM have higher rates of fibrosis progression, cirrhosis, hepatocellular carcinoma (HCC), and both liver-related and cardiovascular mortality than patients without T2DM (5,19–21). The growing global epidemic of T2DM can potentially fuel the future clinical burden of NASH and NASH-related liver complications. In 2015, 23 million adults in the U.S. had been diagnosed with T2DM, with another 7.2 million estimated to be undiagnosed, comprising over 12% of the adult U.S. population. An estimated 1.5 million more adults are expected to be diagnosed with T2DM each year (22). Medical expenditures for patients with diagnosed T2DM are ∼2.3 times higher than those of the general population, with an estimated one in four health care dollars being spent on diabetes care and management (23). This growing global prevalence of T2DM will not only adversely influence the clinical burden of NAFLD but also its economic burden. Therefore, our aim was to estimate the overall economic burden, excess burden due to liver disease, and clinical outcomes of the 2017 adult population diagnosed with T2DM and NAFLD in the U.S. over the next 20 years.

Research Design and Methods

Model Building

We constructed a Markov model with both an incidence and prevalence module using Microsoft Excel (Fig. 1). Both modules had a 20-year horizon, with a cycle length of 1 year. Starting with the diagnosed T2DM population in each age-group cohort, we modeled the incidence of NASH in patients with NAFLD without histologic evidence of NASH (NAFL or fatty liver/simple steatosis) and the prevalent NASH population as of 2017. NASH prevalence was reported for all stages of fibrosis using the Meta-analysis of Histological Data in Viral Hepatitis (METAVIR) scale, from F0 (no fibrosis) to F4 (cirrhosis; represented here as the compensated cirrhosis [CC] health state). The incidence model consisted of 10 health states; patients started with simple steatosis (NAFL) and progressed through the model to NASH fibrosis stages F0–F3, CC, decompensated cirrhosis (DCC), HCC, 1 year post–liver transplant (1yPLT), and PLT, with three absorbing mortality states (liver related, cardiovascular, and background mortality [BM]). The prevalence module excluded the NAFL state but otherwise had health states identical to the incidence module. The prevalence of NASH was defined as any degree of fibrosis from METAVIR stages 0–4, where stage 4 is represented in the model as CC. In both modules, patients transitioned to a different state (or remained in the same state) every year based on the associated transition prob!ability (Supplementary Table 1) and exited the model when they reached one of the three absorbing mortality states.

Figure 1
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1

Model figure for incidence module.

Transition probabilities were calculated from the literature and meta-analyses (Supplementary Table 1). We calculated the relative risk of advanced fibrosis and cirrhosis and cardiovascular mortality for patients with T2DM compared with the general population (24). We multiplied the annual transition rates (back calculated from our transition probabilities) from our previous model by the relative risk (24,25). The relative risk for transitions from low fibrosis states (F0/F1) to higher fibrosis states (F2/F3) and from high fibrosis states (F2/F3) to cirrhosis (CC) was 1.78, and relative risk for transitions from low fibrosis states to cirrhosis was 1.2 for patients with T2DM based on a study assessing independent predictors of liver fibrosis in patients with NAFLD (24) (Supplementary Table 1). Our approach was supported by comparison with a recently published study in which progression to advanced fibrosis was measured in middle-aged Japanese patients with and without T2DM. This study found that the hazard ratio for fibrosis progression was 1.879 (95% CI 1.40–2.52). We calculated the annual transition probability from cumulative incidence reported over 3–10 years; the transition probability in patients without T2DM ranged from 1.02% to 1.37%, and annual transition probability to advanced fibrosis in patients with T2DM ranged from 2.08% to 2.71%. This closely mirrors the annual probabilities to advanced fibrosis used in this model (20) (Supplementary Table 1). Transition probabilities from DCC and HCC states to 1yPLT and from 1yPLT to PLT were adjusted according to the age of the cohort, as patients are less likely to receive and survive a transplant with increasing age, with 1-year survival for liver transplants due to metabolic disease at 89.2% according to the Organ Procurement and Transplantation Network (Supplementary Table 2). Age-related BM was calculated from life tables from the Centers for Disease Control and Prevention (CDC) National Center for Health Statistics and applied in 5-year intervals (26) (Supplementary Table 3).

The overall prevalence of diagnosed T2DM in all age-group cohorts was 9.9%, or 24.7 million adults in the U.S., as determined from the 2017 CDC National Diabetes Statistics Report (22) (Table 1). We used the prevalence of diagnosed T2DM rather than total estimated diabetes population as we would not be able to estimate when (or if) patients would receive a definitive T2DM diagnosis during their lifetime, which is associated with significantly higher direct medical costs.

View this table:
  • View inline
  • View popup
Table 1

Demographic inputs for T2DM, NAFL, and NASH in the U.S. in 2017

Incidence Module

In the incidence module, all patients enter the model in the NAFL state and progress to the NASH with F0 stage according to the age-related annual incidence of NASH (Fig. 1 and Table 1). Each age-group cohort was modeled over a 20-year horizon; thus, we calculated the economic burden associated with the NAFL state, all NASH states, and diabetes costs for each age-group cohort over two decades.

Estimates for the prevalence of NAFL in patients with T2DM depend on the method of diagnosis, BMI, ethnicity, age, and hypertension status of patients involved in the study. As the prevalence of comorbidities associated with both NAFLD and T2DM increases with age, we assumed that the prevalence of NAFL also increased with age. The overall prevalence of overweight (BMI ≥25 and <30 kg/m2), obesity (BMI ≥30 and <40 kg/m2), and severe obesity (BMI >40 kg/m2) in adult patients with T2DM was 26.1% (95% CI 23.2–29.2), 43.5% (95% CI 39.6–47.6), and 17.8% (95% CI 14.8–21.3), respectively (22). We used the prevalence of obesity among patients with T2DM as a proxy for hepatic steatosis/NAFL prevalence in each age-group cohort as liver triglyceride content has been positively associated with increasing BMI and age (although this is not to say that patients with BMI <30 kg/m2 do not have significant hepatic triglyceride content) such that NAFL prevalence increased from 22% in the 18–34 age-group cohort to 58% in the 65+ age-group cohort (22,27–29) (Table 1).

The annual incidence rate of NASH in the general population was 20% of the annual incidence of NAFLD in the general population (5,30); however, the incidence of T2DM in patients with NAFLD is up to five times higher compared with the T2DM incidence in the general population (17,31). As the prevalence of NAFLD is high in patients with T2DM (and vice versa), we assumed that the incidence of NASH and NAFLD would also be two to five times higher in the population diagnosed with T2DM as compared with the general population and named this parameter the T2DM-NASH incidence factor. For our base case analysis, we set the T2DM-NASH incidence factor at 3.5 but varied this in our sensitivity analysis.

Prevalence Module

We estimated NASH prevalence with any degree of fibrosis (F0–CC). The use of certain diagnostic modalities tends to underestimate hepatic steatosis or have low sensitivity below 12.5% liver fat (28,32) or can overestimate the prevalence of NASH (percutaneous liver biopsy, as patients generally have a clinical indication for this invasive procedure or are diagnosed in tertiary care centers). The prevalence of NASH among patients with diagnosed T2DM in other studies has varied from 26% (by liver biopsy in patients with T2DM with normal plasma aminotransferase levels) to 52% using 1H-MRS and liver biopsy (and reporting that 50% of NAFLD patients have NASH) to 96.8% using ultrasound and liver biopsy (with 100% of patients with T2DM having NAFLD) (28,29,33). A recent meta-analysis estimated the global prevalence of NASH among patients with T2DM at 37%; however, we believe that using liver biopsy alone would introduce a bias toward overestimation in our model (17).

The estimated prevalence of advanced fibrosis among biopsied patients with T2DM and NAFLD was 17.02% (95% CI 7.29–34.86); thus, we assumed that 80% of the prevalent NASH population would enter the model in stages F0–F2 and 20% of the prevalent NASH population would enter the model in stages F3/CC (17). Patients would then progress through the model according to appropriate transition probabilities until reaching one of the three absorbing mortality states.

Costs

We calculated the average total annual direct medical cost associated with each health state from the U.S. health system perspective. Costs for NAFLD states in the model were microcosted using 2017 Current Procedural Terminology (CPT) codes, assuming nonfacility prices, global service, and no modifiers (Supplementary Table 4). Costs for fibrosis states included annual low to medium complexity coded physician consultations, transient elastography, lipid panel, liver profile, complete blood count, percutaneous liver biopsy to confirm NASH diagnosis, and one-time screening per patient for hepatitis B and C. Costs for advanced liver disease (states CC through HCC) were derived from the literature, validated by hepatology experts, and adjusted for our analysis (34–36). For those cost data imputed from studies on advanced liver disease in hepatitis C and nonalcoholic liver disease patients, we excluded the cost of antivirals and other disease-specific costs. For liver transplants and associated care for the year after (1yPLT state), we used the billed charges from the 2017 Milliman Research Report on U.S. organ and tissue transplant costs (37) multiplied by the average national cost-to-charge ratio across hospitals from the National Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality (38). Charges for liver transplant and associated care were inclusive of care 30 days pretransplant, organ procurement, hospital transplant admission (facility charges), physician fees, the first 180 days posttransplant discharge, and necessary drugs. For the PLT state, we calculated the cost of antirejection medications and an annual visit with a transplant specialist team for blood draw and associated care using 2017 CPT codes. We did not include NAFLD treatment costs (such as pioglitazone, vitamin E, or intensive weight loss/nutrition programs) or the cost of complications due to HCC or liver transplant, or vary state costs by age-group cohort for NAFLD.

The average annual direct medical costs attributed to diagnosed diabetes for each age-group cohort were taken from a 2017 paper released by the American Diabetes Association. These costs are the incremental costs incurred due to diabetes relative to the general population and are inclusive of institutional care, outpatient care, and outpatient medications and supplies, including insulin (23). As is standard, all future costs were discounted by 3% annually.

Sensitivity Analysis

We conducted a probabilistic sensitivity analysis (PSA) to assess the parameter and varied transition probabilities; costs; prevalence of T2DM, NAFL, and NASH; and incidence of NASH. Probability distributions and parameters for each model input included in the sensitivity analysis can be found in Supplementary Table 4. We used a gamma distribution for costs, beta-PERT (Program Evaluation and Review Technique) distribution for demographic inputs, and Dirichlet (multivariate beta distribution) for transition probabilities. Probability distribution parameters (α and β) for costs and transition probabilities were estimated using a method of moments approach. We used the average value found in the literature for the “most likely” value for beta-PERT probability distributions for demographic inputs. For inputs without a range of values, we set the lower and upper bounds to ±35% of the most likely value. Base case inputs for our probabilistic analysis included adults aged 50–64 years. We averaged results from 10,000 Monte Carlo microsimulations for all parameters in both the incidence and prevalence modules of the model histograms showing the frequency of select outcomes (liver transplants, liver-related mortality, and liver disease–related costs). The aggregated results of 10,000 Monte Carlo microsimulations have been provided in the Supplementary Data.

Results

Deterministic Results

Clinical Burden of NASH With T2DM

The prevalence of diagnosed T2DM among adults in the U.S. was estimated to be 9.9%, comprising 24.7 million adults. The prevalence of NAFLD in the diagnosed T2DM population was estimated to be 18.2 million people out of 24.7 million diagnosed with T2DM. In fact, our model shows that the prevalence of NAFLD among patients with T2DM is 73.5%, which is slightly higher than the mean global prevalence estimated in recent meta-analyses but still within the 95% CI (17,18). The proportion of all adults with both diagnosed T2DM and NAFLD in 2017 is thus estimated to be 7.3%. The prevalence of NAFL in adults with T2DM was estimated to be 47.5%, or 11.7 million people. The prevalence of NASH in patients with T2DM in the U.S. was estimated to be 26%, or 6.4 million patients (Table 1).

We also estimated the clinical burden of NASH with T2DM. Using the incidence module, we estimate that over two decades, there will be nearly 865 liver transplants, 27,000 person-years spent with DCC, and 10,900 person-years spent with HCC. Of patients in the incidence cohort, 55.8% will die of age-related mortality, 17,600 (0.15%) will die of liver-related complications, and 485,000 (4.1%) will die of cardiovascular mortality (Table 2). Although the nature of a Markov model makes it impossible to identify which proportion of cardiovascular deaths are attributable to NAFL versus NASH, adverse liver-related outcomes are entirely attributable to NASH patients as the probability of moving from the NAFL state to any other state except NASH F0, F1, cardiovascular mortality, or BM is not possible.

View this table:
  • View inline
  • View popup
Table 2

Results for incident and prevalent NASH populations, 2017

The prevalence module estimates that 64,000 liver transplants will occur over the next two decades of the prevalent NASH with T2DM cohort, comprising 29% of the total estimated liver transplants performed over that time period. In this cohort, liver-related mortality will account for 795,000 (12.4%) deaths, and cardiovascular mortality will cause 883,000 (13.7%) deaths. Finally, this cohort will experience 1.2 million and 468,000 person-years spent with DCC and HCC, respectively.

In summary, over the next 20 years, out of a cohort of 18.2 million people, NASH and T2DM will be potentially responsible for 64,900 liver transplants, 812,000 liver-related deaths, 1.37 million cardiovascular deaths, 1.27 million DCC person-years, and 479,000 HCC person-years (Table 2).

Economic Burden of NASH in T2DM

The total economic burden for the incident NASH cohort with T2DM was $25.4 billion. Of this cost, $22 billion (87%) was attributable to diabetes care and management and $3.4 billion (13%) related to NASH care. The per-person-per-year cost of incident NASH and T2DM for each age-group cohort in the incidence module is $5,100 for ages 18–34 years, $4,400 for ages 35–49 years, $5,700 for ages 50–64 years, and $10,800 for ages 65 years and over. The economic burden for NAFL was $1 trillion, with $990 billion (98.6%) attributable to diabetes care and $13.7 billion (1.4%) attributable to NAFL care.

The economic burden for the prevalent NASH cohort with T2DM was $642 billion, with $482.2 billion (75%) attributable to diabetes care and management and $160.3 billion (25%) to NASH-related liver care. The per-person-per-year cost of NASH and T2DM for each age-group cohort in the prevalence module is $7,700 for ages 18–34 years, $7,200 for ages 35–49 years, $7,700 for ages 50–64 years, and $13,100 for ages 65 years and over.

In summary, the total cost of NASH with T2DM is $667.9 billion, with $504.2 billion (75.5%) related to diabetes management and $163.7 billion (24.5%) related to NASH care. For all patients with NAFLD and T2DM, the total cost per-person-per-year is $7,700, with costs attributable to diabetes comprising $6,900 (89.4%) of total cost and NAFLD-attributable costs comprising $819 (10.6%) (Table 2).

PSA

Sensitivity analyses for our model showed that for adults aged 50–64 years with diagnosed T2DM in the U.S. and either NAFL or NASH, our model likely underestimates the number of liver transplants and liver-related deaths (Supplementary Table 5). Average results from our PSA were significantly higher than deterministic results for these two outputs and show a large spread when the frequency of each output is plotted (Supplementary Fig. 1A and B). The average lifetime cost calculated from our PSA is close to our deterministic results; however, the range of costs over 10,000 microsimulations in the incidence module has a large spread (Supplementary Fig. 1C). Overall, our model is robust in predicting future costs in the prevalence model but likely underestimates the clinical burden of NAFLD among patients with T2DM.

Conclusions

This is the first study to assess the economic and clinical burden of NASH and NAFLD in patients with T2DM. In this analysis, we used the most recent data from a meta-analysis to obtain the prevalence and transition probabilities for this cohort of patients with T2DM (Supplementary Table 4). We used the most recent cost data to determine the economic burden in the U.S. (Supplementary Table 4). To be complete, we used both prevalence and incidence modules to estimate future outcomes. To evaluate areas of uncertainty, extensive sensitivity analyses were performed.

Our data show that 7.3% of the adult population have NAFLD and T2DM in the U.S., with 6.4 million individuals with diabetes estimated to have underlying NASH. The most significant clinical burden in individuals with diabetes and NAFLD was seen in those with NASH. In fact, the population size of patients with NASH and T2DM was over 1.8 times smaller than the population with T2DM and NAFL but accounted for 43–74 times more adverse clinical outcomes (DCC person-years 46-fold higher, HCC person-years 43-fold higher, liver-related mortality 45-fold higher, and liver transplant 74-fold higher). These data are consistent with the evidence that NASH is the progressive form of NAFLD, and this progression may be exacerbated in the setting of T2DM (19,24,39).

It is also important to remember that cardiovascular mortality is the main cause of death in NAFLD. In our model, cardiovascular mortality is 1.7 times higher than liver mortality for the entire cohort, as both NAFLD and T2DM increase the risk of major adverse cardiac events (11–13,24,40). In contrast, NASH with T2DM also accounts for a large number of liver-related adverse outcomes, which is primarily limited to the progressive NASH.

Our cost data also provided some other interesting insights. As expected, the total cost of NAFLD with T2DM in the U.S. over the next two decades is estimated to be $1.67 trillion. In this context, the majority of costs are related to the diabetes care. This is expected because the majority of patients have NAFL and rarely develop severe liver disease; thus, their health care costs are mostly driven by T2DM management and care. Nevertheless, liver-related health care for this group still accounts for $13.7 billion, which is attributed to annual liver checkups and other related clinical evaluations.

In contrast, the population with NASH and T2DM accounted for substantial cost burden. The total liver-related costs of NASH with T2DM were almost 12 times higher ($163.7 billion vs. $13.7 billion) than NAFL with T2DM. The liver-related costs for NAFL were $95 per person-year, whereas liver-related costs for NASH were 24 times higher at $2,275 per person-year.

The major limitation of our study is the lack of prospective real-world natural history data to determine the true incidence and progression of NASH. Our model also does not take into account rising medical costs (particularly insulin), the costs associated with complications common in advanced liver disease, or the implementation of future costly treatments or technologies to treat NASH or T2DM. Finally, our model does not take into account the pool of NAFLD patients with newly diagnosed diabetes (incident T2DM) or the rising incidence of NAFLD (higher than current rates), which would significantly increase future costs. As our approach was conservative and based on present-day standards, we limited our time horizon for the model to 20 years to reduce uncertainty in model outcomes. Nevertheless, our in-depth approach of performing a meta-analysis prior to establishing this model and updating transition probabilities and cost data with the latest evidence brings substantial strength to our approach.

This model focuses on the incidence of NAFLD in patients with T2DM and the subsequent costs and health outcomes associated with these two conditions. However, the authors recognize that there exists an intricate relationship and dual causality between T2DM and NAFLD and that the mechanisms underlying both diseases are uniquely intertwined. Although we did not focus on the incidence of T2DM in NAFLD subjects in this model, we do believe that NAFLD, as the hepatic manifestation of the metabolic syndrome, plays an important role in the development of and exacerbation of diabetes and other metabolic conditions in a unique, “multiple hit” combination of genetics and environmental factors.

In summary, this analysis suggests that the clinical and economic burden of NASH in patients with T2DM is currently substantial, and as the prevalence of T2DM increases globally, this burden will continue to rise. It is critical that clinicians, payers, policy makers, and the pharmaceutical industry not only understand the clinical burden of NASH in patients with T2DM but also the economic and patient-reported outcomes burden. These multiple assessments provide a more complete outlook of the potential burden of NAFLD and NASH in the U.S.

Article Information

Funding. This study was partially funded by Beatty Liver and Obesity Research Funds, the Inova Health System Foundation, and the Center for Outcomes Research in Liver Disease.

Duality of Interest. This study was partially funded by Bristol-Myers Squibb. Z.M.Y. is a consultant for or received research funds from Bristol-Myers Squibb, Gilead, AbbVie, Intercept, Novo Nordisk, Shinogi, Viking, Terns, and Quest Diagnostics. Y.Q. and L.B. are employees of Bristol-Myers Squibb. No other potential conflicts of interest relevant to this article were reported.

Author Contributions. Z.M.Y. conceived and designed the study, drafted the manuscript, obtained funding, and supervised the study. R.P.T. analyzed and interpreted data, performed statistical analysis, and drafted the manuscript. A.R., Y.Q., L.B., I.Y., and F.N. critically revised the manuscript for important intellectual content and provided administrative, technical, or material support. Z.M.Y. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Footnotes

  • This article contains Supplementary Data online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc19-1113/-/DC1.

  • This article is part of a special article collection available at https://care.diabetesjournals.org/collection/nafld-in-diabetes.

  • This article is featured in a podcast available at http://www.diabetesjournals.org/content/diabetes-core-update-podcasts.

  • See accompanying articles, pp. 275, 290, and 298.

  • Received June 4, 2019.
  • Accepted October 9, 2019.
  • © 2019 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

References

  1. ↵
    1. Chalasani N,
    2. Younossi Z,
    3. Lavine JE, et al.; American Gastroenterological Association; American Association for the Study of Liver Diseases; American College of Gastroenterology
    . The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012;142:1592–1609
    OpenUrlCrossRefPubMedWeb of Science
    1. Younossi Z,
    2. Anstee QM,
    3. Marietti M, et al
    . Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 2018;15:11–20
    OpenUrlCrossRefPubMed
  2. ↵
    1. Younossi ZM
    . Non-alcoholic fatty liver disease - a global public health perspective. J Hepatol 2019;70:531–544
    OpenUrl
  3. ↵
    1. Younossi ZM,
    2. Otgonsuren M,
    3. Venkatesan C,
    4. Mishra A
    . In patients with non-alcoholic fatty liver disease, metabolically abnormal individuals are at a higher risk for mortality while metabolically normal individuals are not. Metabolism 2013;62:352–360
    OpenUrlCrossRefPubMed
  4. ↵
    1. Golabi P,
    2. Otgonsuren M,
    3. de Avila L,
    4. Sayiner M,
    5. Rafiq N,
    6. Younossi ZM
    . Components of metabolic syndrome increase the risk of mortality in nonalcoholic fatty liver disease (NAFLD). Medicine (Baltimore) 2018;97:e0214
    OpenUrl
  5. ↵
    1. Duseja A,
    2. Chalasani N
    . Epidemiology and risk factors of nonalcoholic fatty liver disease (NAFLD). Hepatol Int 2013;7(Suppl. 2):755–764
    OpenUrl
  6. ↵
    1. Zelber-Sagi S,
    2. Nitzan-Kaluski D,
    3. Halpern Z,
    4. Oren R
    . Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006;26:856–863
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Younossi ZM,
    2. Koenig AB,
    3. Abdelatif D,
    4. Fazel Y,
    5. Henry L,
    6. Wymer M
    . Global epidemiology of nonalcoholic fatty liver disease—meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology 2016;64:73–84
    OpenUrlCrossRefPubMed
  8. ↵
    1. Le MH,
    2. Devaki P,
    3. Ha NB, et al
    . Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States. PLoS One 2017;12:e0173499
    OpenUrl
  9. ↵
    1. Misra VL,
    2. Khashab M,
    3. Chalasani N
    . Nonalcoholic fatty liver disease and cardiovascular risk. Curr Gastroenterol Rep 2009;11:50–55
    OpenUrlCrossRefPubMed
  10. ↵
    1. Mellinger JL,
    2. Pencina KM,
    3. Massaro JM, et al
    . Hepatic steatosis and cardiovascular disease outcomes: an analysis of the Framingham Heart Study. J Hepatol 2015;63:470–476
    OpenUrlCrossRefPubMed
    1. Targher G,
    2. Bertolini L,
    3. Rodella S, et al
    . Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care 2007;30:2119–2121
    OpenUrlFREE Full Text
  11. ↵
    1. Drapkina OM,
    2. Yafarova AA
    . Non-alcoholic fatty liver disease and cardiovascular risk: scientific problem state. Ration Pharmacother Cardiol 2017;13:645–650
    OpenUrl
  12. ↵
    1. Sayiner M,
    2. Otgonsuren M,
    3. Cable R, et al
    . Variables associated with inpatient and outpatient resource utilization among Medicare beneficiaries with nonalcoholic fatty liver disease with or without cirrhosis. J Clin Gastroenterol 2017;51:254–260
    OpenUrl
    1. Younossi ZM,
    2. Zheng L,
    3. Stepanova M,
    4. Henry L,
    5. Venkatesan C,
    6. Mishra A
    . Trends in outpatient resource utilizations and outcomes for Medicare beneficiaries with nonalcoholic fatty liver disease. J Clin Gastroenterol 2015;49:222–227
    OpenUrl
  13. ↵
    1. Younossi ZM
    . Patient-reported outcomes and the economic effects of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: the value proposition. Hepatology 2018;68:2405–2412
    OpenUrl
  14. ↵
    1. Younossi ZM,
    2. Golabi P,
    3. de Avila L, et al
    . The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis. J Hepatol 2019;71:793–801
    OpenUrl
  15. ↵
    1. Dai W,
    2. Ye L,
    3. Liu A, et al
    . Prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a meta-analysis. Medicine (Baltimore) 2017;96:e8179
    OpenUrl
  16. ↵
    1. Younossi ZM,
    2. Gramlich T,
    3. Matteoni CA,
    4. Boparai N,
    5. McCullough AJ
    . Nonalcoholic fatty liver disease in patients with type 2 diabetes. Clin Gastroenterol Hepatol 2004;2:262–265
    OpenUrlCrossRefPubMed
  17. ↵
    1. Tada T,
    2. Toyoda H,
    3. Sone Y, et al
    . Type 2 diabetes mellitus: a risk factor for progression of liver fibrosis in middle-aged patients with non-alcoholic fatty liver disease. J Gastroenterol Hepatol 2019;34:2011–2018
    OpenUrl
  18. ↵
    1. El-Serag HB,
    2. Tran T,
    3. Everhart JE
    . Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004;126:460–468
    OpenUrlCrossRefPubMedWeb of Science
  19. ↵
    1. Centers for Disease Control and Prevention
    . National Diabetes Statistics Report, 2017. Atlanta, GA, Centers for Disease Control and Prevention, 2017
  20. ↵
    1. Yang W,
    2. Dall TM,
    3. Beronjia K, et al.; American Diabetes Association
    . Economic costs of diabetes in the U.S. in 2017. Diabetes Care 2018;41:917–928
    OpenUrlAbstract/FREE Full Text
  21. ↵
    1. Hossain N,
    2. Afendy A,
    3. Stepanova M, et al
    . Independent predictors of fibrosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2009;7:1224–1229, 1229.e1-2
    OpenUrlCrossRefPubMed
  22. ↵
    1. Younossi ZM,
    2. Tampi R,
    3. Priyadarshini M,
    4. Nader F,
    5. Younossi IM,
    6. Racila A
    . Burden of illness and economic model for patients with non-alcoholic steatohepatitis (NASH) in the United States. Hepatology 2019;69:564–572
    OpenUrl
  23. ↵
    1. Arias E,
    2. Heron M,
    3. Xu J
    . United States life tables. National Vital Statistics Reports 66(4) [Internet], 2017. Available from https://www.cdc.gov/nchs/data/nvsr/nvsr66/nvsr66_04.pdf. Accessed 17 April 2018
  24. ↵
    1. Iglay K,
    2. Hannachi H,
    3. Joseph Howie P, et al
    . Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus. Curr Med Res Opin 2016;32:1243–1252
    OpenUrlCrossRefPubMed
  25. ↵
    1. Portillo-Sanchez P,
    2. Bril F,
    3. Maximos M, et al
    . High prevalence of nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and normal plasma aminotransferase levels. J Clin Endocrinol Metab 2015;100:2231–2238
    OpenUrlCrossRefPubMed
  26. ↵
    1. Bril F,
    2. Millán L,
    3. Kalavalapalli S, et al
    . Use of a metabolomic approach to non-invasively diagnose non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus. Diabetes Obes Metab 2018;20:1702–1709
    OpenUrl
  27. ↵
    1. Allen AM,
    2. Therneau TM,
    3. Larson JJ,
    4. Coward A,
    5. Somers VK,
    6. Kamath PS
    . Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: a 20 year-community study. Hepatology 2018;67:1726–1736
    OpenUrlCrossRefPubMed
  28. ↵
    1. Mantovani A,
    2. Byrne CD,
    3. Bonora E,
    4. Targher G
    . Nonalcoholic fatty liver disease and risk of incident type 2 diabetes: a meta-analysis. Diabetes Care 2018;41:372–382
    OpenUrlAbstract/FREE Full Text
  29. ↵
    1. Bril F,
    2. Ortiz-Lopez C,
    3. Lomonaco R, et al
    . Clinical value of liver ultrasound for the diagnosis of nonalcoholic fatty liver disease in overweight and obese patients. Liver Int 2015;35:2139–2146
    OpenUrlCrossRefPubMed
  30. ↵
    1. Masarone M,
    2. Rosato V,
    3. Aglitti A, et al
    . Liver biopsy in type 2 diabetes mellitus: steatohepatitis represents the sole feature of liver damage. PLoS One 2017;12:e0178473
    OpenUrl
  31. ↵
    1. Kaplan DE,
    2. Chapko MK,
    3. Mehta R, et al.; VOCAL Study Group
    . Healthcare costs related to treatment of hepatocellular carcinoma among veterans with cirrhosis in the United States. Clin Gastroenterol Hepatol 2018;16:106–114.e5
    OpenUrl
    1. McAdam-Marx C,
    2. McGarry LJ,
    3. Hane CA,
    4. Biskupiak J,
    5. Deniz B,
    6. Brixner DI
    . All-cause and incremental per patient per year cost associated with chronic hepatitis C virus and associated liver complications in the United States: a managed care perspective. J Manag Care Pharm 2011;17:531–546
    OpenUrlPubMed
  32. ↵
    1. Allen AM,
    2. Van Houten HK,
    3. Sangaralingham LR,
    4. Talwalkar JA,
    5. McCoy RG
    . Healthcare cost and utilization in nonalcoholic fatty liver disease: real-world data from a large U.S. claims database. Hepatology 2018;68:2230–2238
    OpenUrl
  33. ↵
    1. Bentley TS,
    2. Phillips SJ,
    3. Hanson SG
    . 2017 U.S. organ and tissue transplant cost estimates and discussion [Internet], 2017. Available from http://us.milliman.com/uploadedFiles/insight/2017/2017-Transplant-Report.pdf. Accessed 15 December 2018
  34. ↵
    1. HCUP National Inpatient Sample (NIS)
    . Cost-to-charge ratio files (CCR). Healthcare Cost and Utilization Project (HCUP) [Internet], 2016. Rockville, MD, Agency for Healthcare Research and Quality (AHRQ). Available from https://www.hcup-us.ahrq.gov/db/state/costtocharge.jsp. Accessed 25 April 2019
  35. ↵
    1. Angulo P,
    2. Kleiner DE,
    3. Dam-Larsen S, et al
    . Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 2015;149:389.e10–397.e10
    OpenUrl
  36. ↵
    1. Younossi ZM,
    2. Otgonsuren M,
    3. Henry L, et al
    . Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009. Hepatology 2015;62:1723–1730
    OpenUrlCrossRefPubMed
PreviousNext
Back to top
Diabetes Care: 43 (2)

In this Issue

February 2020, 43(2)
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by Author
  • Masthead (PDF)
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes Care.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Economic and Clinical Burden of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes in the U.S.
(Your Name) has forwarded a page to you from Diabetes Care
(Your Name) thought you would like to see this page from the Diabetes Care web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Economic and Clinical Burden of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes in the U.S.
Zobair M. Younossi, Radhika P. Tampi, Andrei Racila, Ying Qiu, Leah Burns, Issah Younossi, Fatema Nader
Diabetes Care Feb 2020, 43 (2) 283-289; DOI: 10.2337/dc19-1113

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Economic and Clinical Burden of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes in the U.S.
Zobair M. Younossi, Radhika P. Tampi, Andrei Racila, Ying Qiu, Leah Burns, Issah Younossi, Fatema Nader
Diabetes Care Feb 2020, 43 (2) 283-289; DOI: 10.2337/dc19-1113
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Research Design and Methods
    • Results
    • Conclusions
    • Article Information
    • Footnotes
    • References
  • Figures & Tables
  • Suppl Material
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Time to Include Nonalcoholic Steatohepatitis in the Management of Patients With Type 2 Diabetes
  • Role of Exercise in Mitigating Pediatric Nonalcoholic Fatty Liver Disease
Show more Nonalcoholic Fatty Liver Disease in Diabetes

Similar Articles

Subjects

  • Nonalcoholic Fatty Liver Disease in Diabetes
  • Epidemiology-Other

Navigate

  • Current Issue
  • Standards of Care Guidelines
  • Online Ahead of Print
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • Advertising
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes
  • Clinical Diabetes
  • Diabetes Spectrum
  • Scientific Sessions Abstracts
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.