Acute Hyperglycemia and Spatial Working Memory in Adolescents With Type 1 Diabetes

Differences in brain activation as assessed by functional MRI during the performance of the sWM task between adolescents with T1D and healthy control subjects. A shows a priori ROIs. B presents the change of activation in ROIs between first and second session in the group with T1D and the healthy control group. C presents change of activation in ROIs between the first and second session in the group with T1D and the healthy control group shown separately for each phase of working memory task and hemisphere. D presents mean time courses of activation in ROIs by group, hemisphere, and session, showing higher levels of activation in participants with T1D during euglycemia and a decrease of activation during hyperglycemia. AI, anterior insula; AIP, anterior intraparietal area; DLPFC, dorsolateral prefrontal cortex; FEF, frontal eye field; IFJ, inferior frontal junction; L, left; MIP, medial intraparietal area; MTL, medial temporal lobe; R, right; SMA, supplementary motor area.