Erogress Toward a Potentially Implantable, Enzyme-Based Glucose Sensor

David A Gough; John K Leypoldt; Jon C Armour

doi:10.2337/diacare.5.3.190

Symposium on Potentially Implantable Glucose Sensors

Erogress Toward a Potentially Implantable, Enzyme-Based Glucose Sensor

David A Gough,
John K Leypoldt and
Jon C Armour

Department of Applied Mechanics and Engineering Sciences, Bioengineering Group, University of California San Diego, La Jolla, California 92093

Address reprint requests to David A. Gough, University of California, San Diego, Department of Applied Mechanics and Engineering Sciences, Bioengineering Group, La Jolla, California 92093.

Diabetes Care 1982 May; 5(3): 190-198. https://doi.org/10.2337/diacare.5.3.190

Abstract

Our efforts toward the development of a potentially implantable, enzyme-based glucose sensor have concentrated on understanding in sufficient detail the most important component, the enzyme-containing membrane. We describe here some features that this membrane must have to operate as a constituent of a chronically implanted sensor. A model of reaction and diffusion within the membrane is outlined and methods of membrane characterization are reviewed.