The Long-term Effects of Chlorpropamide on Insulin, C-Peptide, and Proinsulin Secretion
Abstract
It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with chlorpropamide for over 3 mo. Of these, 9 were also studied after 1 yr. Improvement in glucose tolerance was associated with an increase in fasting and postglucose serum insulin and C-peptide concentration. We conclude that at least for over 1 yr chlorpropamide increases insulin secretion. After 3 and 12 mo the fasting proinsulin percentage of immunoreactive insulin was increased.
- Copyright © 1982 by the American Diabetes Association
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In this Issue
July 1982, 5(4)
The Long-term Effects of Chlorpropamide on Insulin, C-Peptide, and Proinsulin Secretion
