Search for the Most Practical Regular/NPH Mixtures for Type I Diabetic Patients

R Renner; K Vocke; K D Hepp

doi:10.2337/diacare.5.2.S53

Pharmacology

Search for the Most Practical Regular/NPH Mixtures for Type I Diabetic Patients

R Renner,
K Vocke and
K D Hepp

Department of Medicine, Oberföhring City Hospital Munich, West Germany

Address reprint requests to Dr. R. Renner, Krankenhaus Munchen-Oberföhring, Medizinische Abteilung, Oberfohringer Strasse 156, 8000 Munchen 81, West Germany

Diabetes Care 1982 Nov; 5(Supplement 2): 53-56. https://doi.org/10.2337/diacare.5.2.S53

Abstract

After 2 wk of good control 9 type I diabetic patients were hospitalized and treated in a randomized fashion with different human insulin mixtures (regular: NPH), containing 10, 15, or 20% regular insulin. In the case of the 15:85% mixture, mean blood glucose was found to be in the range of 70–150 mg/dl. Significant differences occurred at certain time points between the curves obtained with the 10:90% and the 15:85% mixtures, and the 10:90% and the 20:80% preparations, respectively. Prolongation of the interval between hormone injection and start of breakfast from 30 to 45 min abolished the postprandial glucose excursion in the 15:85% and the 20:80% mixture, but not the 10:90% mixture.