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Original Research
Effects of weight loss among metabolically healthy obese men and women
Peter M. Janiszewski, Robert Ross
Diabetes Care 2010 Jun; https://doi.org/10.2337/dc10-0547
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Abstract

Objective: Weight loss among metabolically healthy obese (MHO) individuals may be unnecessary or result in elevated cardiometabolic risk. We studied the effects of exercise- or diet-induced weight loss on cardiometabolic risk among MHO and metabolically abnormal obese (MAO) adults.

Research Design and Methods: Sixty three MHO and 43 MAO adults participated in 3-6 months of exercise- or diet-induced weight loss intervention. Changes in anthropometry, adipose tissue distribution and cardiometabolic risk factors were assessed.

Results: Body weight, waist circumference and total, abdominal and visceral adipose tissue were reduced in all subjects (P < 0.05). Improvements in insulin sensitivity were observed in MHO and MAO men and women (P<0.05), but was greater in the MAO (P<0.05). Fasting insulin was the only other cardiometabolic improvement among MHO (P<0.05).

Conclusions: Lifestyle-induced weight loss among MHO subjects is associated with a reduction in total and abdominal obesity and improvement in selected cardiometabolic risk factors.

Footnotes

    • Received March 23, 2010.
    • Accepted June 14, 2010.
    • Copyright © American Diabetes Association
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    Diabetes Care: 44 (4)

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    April 2021
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    Effects of weight loss among metabolically healthy obese men and women
    Peter M. Janiszewski, Robert Ross
    Diabetes Care Jun 2010, DOI: 10.2337/dc10-0547

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    Effects of weight loss among metabolically healthy obese men and women
    Peter M. Janiszewski, Robert Ross
    Diabetes Care Jun 2010, DOI: 10.2337/dc10-0547
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