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Brief Report
Circulating Dopamine and C-Peptide Levels in Fasting Nondiabetic Hypertensive Patients
Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pieske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz
Diabetes Care 2012 Jun; DC_112384. https://doi.org/10.2337/dc11-2384
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Abstract

OBJECTIVE Accumulating evidence supports a potential role for dopamine in the regulation of insulin secretion. We examined the association between circulating dopamine and C-peptide concentrations using data from the Graz Endocrine Causes of Hypertension Study.

RESEARCH DESIGN AND METHODS After 12 h of fasting, we measured plasma dopamine and serum C-peptide levels and established determining factors of insulin secretion in 201 nondiabetic hypertensive patients (mean age 48.1 ± 16.0 years; 61.7% women).

RESULTS Mean dopamine and C-peptide concentration were 33.4 ± 38.6 pg/mL and 3.1 ± 2.7 ng/mL, respectively. A strong and inverse correlation was observed between dopamine and C-peptide levels (r = −0.423, P < 0.001). There was no significant relationship between C-peptide, plasma epinephrine, and norepinephrine. C-peptide levels decreased steadily and significantly from tertile 1 of dopamine (3.6 ng/mL [95% CI 2.9–4.1]) to tertile 3 (1.6 ng/mL [1.5–2.7], P < 0.001) after multivariate adjustment.

CONCLUSIONS The inverse association between dopamine and C-peptide highlights the need to evaluate whether dopamine could be effective for modulating endocrine pancreatic function.

  • Received December 7, 2011.
  • Accepted March 27, 2012.
  • © 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Circulating Dopamine and C-Peptide Levels in Fasting Nondiabetic Hypertensive Patients
Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pieske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz
Diabetes Care Jun 2012, DC_112384; DOI: 10.2337/dc11-2384

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Circulating Dopamine and C-Peptide Levels in Fasting Nondiabetic Hypertensive Patients
Andreas Tomaschitz, Eberhard Ritz, Katharina Kienreich, Burkert Pieske, Winfried März, Bernhard O. Boehm, Christiane Drechsler, Andreas Meinitzer, Stefan Pilz
Diabetes Care Jun 2012, DC_112384; DOI: 10.2337/dc11-2384
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© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.