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Original Research
Infancy-Onset Dietary Counseling of Low-Saturated-Fat Diet Improves Insulin Sensitivity in Healthy Adolescents 15–20 Years of Age:
Olli Oranta, Katja Pahkala, Soile Ruottinen, Harri Niinikoski, Hanna Lagström, Jorma S.A. Viikari, Antti Jula, Britt-Marie Loo, Olli Simell, Tapani Rönnemaa, Olli T. Raitakari
Diabetes Care 2013 Jun; DC_130361. https://doi.org/10.2337/dc13-0361
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Abstract

OBJECTIVE We reported previously that low-saturated-fat dietary counseling started in infancy improves insulin sensitivity in healthy children 9 years of age. The aim of this study was to evaluate the effect of life-long dietary counseling on insulin sensitivity in healthy adolescents between 15 and 20 years of age. In addition, we examined dietary fiber intake and the polyunsaturated fatty acid (PUFA) + monounsaturated (MUFA)-to-saturated fatty acid (SFA) ratio in the intervention and control adolescents and the association of these dietary factors with homeostasis model of insulin resistance (HOMA-IR).

RESEARCH DESIGN AND METHODS The study comprised adolescents participating in the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) study, which aims to guide the study participants toward a diet beneficial for cardiovascular health. HOMA-IR was assessed annually between 15 and 20 years of age (n = 518; intervention, n = 245; control, n = 273), along with diet, BMI, pubertal status, serum cotinine concentrations, and physical activity. Dietary counseling was given biannually during the follow-up.

RESULTS HOMA-IR was lower (7.5% on average) in the intervention group than in the control group between 15 and 20 years of age (P = 0.0051). The intervention effect was similar in girls and boys. The PUFA+MUFA-to-SFA ratio was higher (P < 0.0001) and the dietary fiber (g/MJ) intake was higher (P = 0.0058) in the intervention group compared with the control group. There was no association between the PUFA+MUFA-to-/SFA ratio and HOMA-IR, whereas dietary fiber intake (g/MJ) was associated with HOMA-IR in girls (P < 0.0001).

CONCLUSIONS Dietary counseling initiated in infancy and maintained until 20 years of age was associated with improved insulin sensitivity in adolescents.

  • Received February 12, 2013.
  • Accepted April 20, 2013.
  • © 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Diabetes Care: 44 (3)

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March 2021
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Infancy-Onset Dietary Counseling of Low-Saturated-Fat Diet Improves Insulin Sensitivity in Healthy Adolescents 15–20 Years of Age:
Olli Oranta, Katja Pahkala, Soile Ruottinen, Harri Niinikoski, Hanna Lagström, Jorma S.A. Viikari, Antti Jula, Britt-Marie Loo, Olli Simell, Tapani Rönnemaa, Olli T. Raitakari
Diabetes Care Jun 2013, DC_130361; DOI: 10.2337/dc13-0361

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Infancy-Onset Dietary Counseling of Low-Saturated-Fat Diet Improves Insulin Sensitivity in Healthy Adolescents 15–20 Years of Age:
Olli Oranta, Katja Pahkala, Soile Ruottinen, Harri Niinikoski, Hanna Lagström, Jorma S.A. Viikari, Antti Jula, Britt-Marie Loo, Olli Simell, Tapani Rönnemaa, Olli T. Raitakari
Diabetes Care Jun 2013, DC_130361; DOI: 10.2337/dc13-0361
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© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.