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Original Research
Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes
Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Erin Moshier, Elizabeth Guerrero-Berroa, Laili Soleimani, Mary Sano, Derek Leroith, Rachel Preiss, Ruth Tzukran, Jeremy M. Silverman, Michal Schnaider Beeri
Diabetes Care 2017 Jun; dc162754. https://doi.org/10.2337/dc16-2754
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Abstract

OBJECTIVE This study aimed to analyze the relationship of variability in hemoglobin A1c (HbA1c) over years with subsequent depressive symptoms.

RESEARCH DESIGN AND METHODS Subjects (n = 837) were participants of the Israel Diabetes and Cognitive Decline (IDCD) study, which aimed to examine the relationship of characteristics of long-term type 2 diabetes with cognitive decline. All pertain to a diabetes registry established in 1998, which contains an average of 18 HbA1c measurements per subject. The results presented here are based on the IDCD baseline examination. Symptoms of depression were assessed using the 15-item version of the Geriatric Depression Scale (GDS). To quantify the association between variability in glycemic control (measured as the SD of HbA1c measurements [HbA1c-SD]) since 1998 with the number of depression symptoms at IDCD baseline, incidence rate ratios (IRRs) and corresponding 95% CIs were estimated via negative binomial regression modeling and used to account for the overdispersion in GDS scores.

RESULTS Subjects’ ages averaged 72.74 years (SD 4.63 years), and the mean number of years in the diabetes registry was 8.7 (SD 2.64 years). The mean GDS score was 2.16 (SD 2.26); 10% of subjects had a GDS score ≥6, the cutoff for clinically significant depression. Mean HbA1c significantly correlated with HbA1c-SD (r = 0.6625; P < 0.0001). The SD, but not the mean, of HbA1c measurements was significantly associated with the number of subsequent depressive symptoms. For each additional 1% increase in HbA1c-SD, the number of depressive symptoms increased by a factor of 1.31 (IRR = 1.31 [95% CI 1.03–1.67]; P = 0.03).

CONCLUSIONS Variability in glycemic control is associated with more depressive symptoms.

  • Received December 26, 2016.
  • Accepted May 19, 2017.
  • © 2017 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes
Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Erin Moshier, Elizabeth Guerrero-Berroa, Laili Soleimani, Mary Sano, Derek Leroith, Rachel Preiss, Ruth Tzukran, Jeremy M. Silverman, Michal Schnaider Beeri
Diabetes Care Jun 2017, dc162754; DOI: 10.2337/dc16-2754

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Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes
Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Erin Moshier, Elizabeth Guerrero-Berroa, Laili Soleimani, Mary Sano, Derek Leroith, Rachel Preiss, Ruth Tzukran, Jeremy M. Silverman, Michal Schnaider Beeri
Diabetes Care Jun 2017, dc162754; DOI: 10.2337/dc16-2754
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