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Original Research
Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank
Céline Vetter, Hassan S. Dashti, Jacqueline M. Lane, Simon G. Anderson, Eva S. Schernhammer, Martin K. Rutter, Richa Saxena, Frank A.J.L. Scheer
Diabetes Care 2018 Feb; dc171933. https://doi.org/10.2337/dc17-1933
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Abstract

OBJECTIVE To examine the effects of past and current night shift work and genetic type 2 diabetes vulnerability on type 2 diabetes odds.

RESEARCH DESIGN AND METHODS In the UK Biobank, we examined associations of current (N = 272,214) and lifetime (N = 70,480) night shift work exposure with type 2 diabetes risk (6,770 and 1,191 prevalent cases, respectively). For 180,704 and 44,141 unrelated participants of European ancestry (4,002 and 726 cases, respectively) with genetic data, we assessed whether shift work exposure modified the relationship between a genetic risk score (comprising 110 single-nucleotide polymorphisms) for type 2 diabetes and prevalent diabetes.

RESULTS Compared with day workers, all current night shift workers were at higher multivariable-adjusted odds for type 2 diabetes (none or rare night shifts: odds ratio [OR] 1.15 [95% CI 1.05–1.26]; some nights: OR 1.18 [95% CI 1.05–1.32]; and usual nights: OR 1.44 [95% CI 1.19–1.73]), except current permanent night shift workers (OR 1.09 [95% CI 0.93–1.27]). Considering a person’s lifetime work schedule and compared with never shift workers, working more night shifts per month was associated with higher type 2 diabetes odds (<3/month: OR 1.24 [95% CI 0.90–1.68]; 3–8/month: OR 1.11 [95% CI 0.90–1.37]; and >8/month: OR 1.36 [95% CI 1.14–1.62]; Ptrend = 0.001). The association between genetic type 2 diabetes predisposition and type 2 diabetes odds was not modified by shift work exposure.

CONCLUSIONS Our findings show that night shift work, especially rotating shift work including night shifts, is associated with higher type 2 diabetes odds and that the number of night shifts worked per month appears most relevant for type 2 diabetes odds. Also, shift work exposure does not modify genetic risk for type 2 diabetes, a novel finding that warrants replication.

Footnotes

  • This article contains Supplementary Data online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc17-1933/-/DC1.

  • Received September 15, 2017.
  • Accepted January 2, 2018.
  • © 2018 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank
Céline Vetter, Hassan S. Dashti, Jacqueline M. Lane, Simon G. Anderson, Eva S. Schernhammer, Martin K. Rutter, Richa Saxena, Frank A.J.L. Scheer
Diabetes Care Feb 2018, dc171933; DOI: 10.2337/dc17-1933

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Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank
Céline Vetter, Hassan S. Dashti, Jacqueline M. Lane, Simon G. Anderson, Eva S. Schernhammer, Martin K. Rutter, Richa Saxena, Frank A.J.L. Scheer
Diabetes Care Feb 2018, dc171933; DOI: 10.2337/dc17-1933
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© 2021 by the American Diabetes Association. Diabetes Care Print ISSN: 0149-5992, Online ISSN: 1935-5548.