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Research ArticleEmerging Technologies: Data Systems and Devices
Open Access

Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial

Martin Tauschmann, Janet M. Allen, Katrin Nagl, Maria Fritsch, James Yong, Emily Metcalfe, Dominique Schaeffer, Muriel Fichelle, Ulrike Schierloh, Alena G. Thiele, Daniela Abt, Harald Kojzar, Julia K. Mader, Sonja Slegtenhorst, Nicole Barber, Malgorzata E. Wilinska, Charlotte Boughton, Gianluca Musolino, Judy Sibayan, Nathan Cohen, Craig Kollman, Sabine E. Hofer, Elke Fröhlich-Reiterer, Thomas M. Kapellen, Carlo L. Acerini, Carine de Beaufort, Fiona Campbell, Birgit Rami-Merhar, Roman Hovorka
DOI: 10.2337/dc18-1881 Published 1 April 2019
Martin Tauschmann
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
2Department of Paediatrics, University of Cambridge, Cambridge, U.K.
3Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
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Janet M. Allen
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
2Department of Paediatrics, University of Cambridge, Cambridge, U.K.
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Katrin Nagl
3Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
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Maria Fritsch
3Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
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James Yong
4Department of Paediatric Diabetes, Leeds Children’s Hospital, Leeds, U.K.
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Emily Metcalfe
4Department of Paediatric Diabetes, Leeds Children’s Hospital, Leeds, U.K.
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Dominique Schaeffer
5Department of Pediatric Diabetes and Endocrinology, Clinique Pédiatrique, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg
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Muriel Fichelle
5Department of Pediatric Diabetes and Endocrinology, Clinique Pédiatrique, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg
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Ulrike Schierloh
5Department of Pediatric Diabetes and Endocrinology, Clinique Pédiatrique, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg
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Alena G. Thiele
6Division for Paediatric Diabetology, University of Leipzig, Leipzig, Germany
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Daniela Abt
7Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria
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Harald Kojzar
8Department of Internal Medicine, Medical University of Graz, Graz, Austria
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Julia K. Mader
8Department of Internal Medicine, Medical University of Graz, Graz, Austria
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  • ORCID record for Julia K. Mader
Sonja Slegtenhorst
9Department of Nutrition and Dietetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, U.K.
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Nicole Barber
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
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Malgorzata E. Wilinska
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
2Department of Paediatrics, University of Cambridge, Cambridge, U.K.
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Charlotte Boughton
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
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Gianluca Musolino
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
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Judy Sibayan
10Jaeb Center for Health Research, Tampa, FL
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Nathan Cohen
10Jaeb Center for Health Research, Tampa, FL
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Craig Kollman
10Jaeb Center for Health Research, Tampa, FL
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Sabine E. Hofer
7Department of Pediatrics, Medical University of Innsbruck, Innsbruck, Austria
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Elke Fröhlich-Reiterer
11Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria
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Thomas M. Kapellen
6Division for Paediatric Diabetology, University of Leipzig, Leipzig, Germany
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Carlo L. Acerini
2Department of Paediatrics, University of Cambridge, Cambridge, U.K.
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Carine de Beaufort
5Department of Pediatric Diabetes and Endocrinology, Clinique Pédiatrique, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg
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Fiona Campbell
4Department of Paediatric Diabetes, Leeds Children’s Hospital, Leeds, U.K.
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Birgit Rami-Merhar
3Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria
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Roman Hovorka
1Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
2Department of Paediatrics, University of Cambridge, Cambridge, U.K.
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  • ORCID record for Roman Hovorka
  • For correspondence: rh347@cam.ac.uk

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