RT Journal Article
SR Electronic
T1 A Prospective Analysis of the HOMA Model: The Mexico City Diabetes Study
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 1138
OP 1141
DO 10.2337/diacare.19.10.1138
VO 19
IS 10
A1 Haffner, Steven M
A1 Gonzalez, Clicerio
A1 Miettinen, Heikki
A1 Kennedy, Esmarie
A1 Stern, Michael P
YR 1996
UL http://care.diabetesjournals.org/content/19/10/1138.abstract
AB OBJECTIVE Both insulin resistance (IR) and decreased insulin secretion have been shown to predict the development of NIDDM. However, methods to assess insulin sensitivity and secretion are complicated and expensive to apply in epidemiological studies. The homeostasis model assessment (HOMA) has been suggested as a method to assess IR and secretion from the fasting glucose and insulin concentrations. RESEARCH DESIGN AND METHODS We applied the HOMA model in the 3.5-year follow-up of the Mexico City Diabetes Study. RESULTS Out of 1,449 subjects, 97 developed diabetes. When modeled separately insulin resistance but not insulin secretion predicted NIDDM. However, when both variables were entered into the same regression model, both increased IR and decreased β-cell function significantly predicted NIDDM. CONCLUSIONS We conclude that the HOMA provides a useful model to assess ²-cell function in epidemiological studies and that it is important to take into account the degree of IR in assessing insulin secretion.