RT Journal Article
SR Electronic
T1 Increased Visceral Fat and Serum Levels of Triglyceride Are Associated With Insulin Resistance in Japanese Metabolically Obese, Normal Weight Subjects With Normal Glucose Tolerance
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 2341
OP 2344
DO 10.2337/diacare.26.8.2341
VO 26
IS 8
A1 Katsuki, Akira
A1 Sumida, Yasuhiro
A1 Urakawa, Hideki
A1 Gabazza, Esteban C.
A1 Murashima, Shuichi
A1 Maruyama, Noriko
A1 Morioka, Kohei
A1 Nakatani, Kaname
A1 Yano, Yutaka
A1 Adachi, Yukihiko
YR 2003
UL http://care.diabetesjournals.org/content/26/8/2341.abstract
AB OBJECTIVE—The purpose of this study was to investigate the association between visceral adiposity or triglyceride (TG) metabolism and insulin resistance in metabolically obese, normal weight (MONW) Japanese individuals with normal glucose tolerance. RESEARCH DESIGN AND METHODS—We evaluated body fat areas, lipid profiles, and the glucose infusion rate (GIR) during a euglycemic-hyperinsulinemic clamp study in 20 MONW subjects (BMI <25 kg/m2and visceral fat areas 100 cm2) with normal glucose tolerance. Body fat areas were measured by computed tomography scans. Control data were obtained from 20 normal subjects (BMI <25 kg/m2 and visceral fat areas <100 cm2). RESULTS—MONW subjects showed a significant increase in fasting serum levels of TG (P < 0.01) and a decrease in GIR (P < 0.01) compared with normal subjects. There were significant correlations between visceral fat areas (r = −0.563, P < 0.01) or serum levels of TG (r = −0.474, P < 0.05) and GIR in MONW subjects. Multiple regression analyses showed that visceral fat areas (F = 7.702, P < 0.02) and serum levels of TG (F = 7.114, P < 0.05) were significantly associated with GIR in all (MONW and normal) subjects. CONCLUSIONS—Increased visceral fat and serum levels of TG are associated with insulin resistance in Japanese MONW subjects with normal glucose tolerance. Excess visceral fat and elevated TG levels may play important roles in the development of insulin resistance in Japanese MONW subjects with normal glucose tolerance.