RT Journal Article
SR Electronic
T1 A Single Factor Underlies the Metabolic Syndrome
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 113
OP 122
DO 10.2337/diacare.29.01.06.dc05-0862
VO 29
IS 1
A1 Pladevall, Manel
A1 Singal, Bonita
A1 Williams, L. Keoki
A1 Brotons, Carlos
A1 Guyer, Heidi
A1 Sadurni, Josep
A1 Falces, Carles
A1 Serrano-Rios, Manuel
A1 Gabriel, Rafael
A1 Shaw, Jonathan E.
A1 Zimmet, Paul Z.
A1 Haffner, Steven
YR 2006
UL http://care.diabetesjournals.org/content/29/1/113.abstract
AB OBJECTIVE—Confirmatory factor analysis (CFA) was used to test the hypothesis that the components of the metabolic syndrome are manifestations of a single common factor. RESEARCH DESIGN AND METHODS—Three different datasets were used to test and validate the model. The Spanish and Mauritian studies included 207 men and 203 women and 1,411 men and 1,650 women, respectively. A third analytical dataset including 847 men was obtained from a previously published CFA of a U.S. population. The one-factor model included the metabolic syndrome core components (central obesity, insulin resistance, blood pressure, and lipid measurements). We also tested an expanded one-factor model that included uric acid and leptin levels. Finally, we used CFA to compare the goodness of fit of one-factor models with the fit of two previously published four-factor models. RESULTS—The simplest one-factor model showed the best goodness-of-fit indexes (comparative fit index 1, root mean-square error of approximation 0.00). Comparisons of one-factor with four-factor models in the three datasets favored the one-factor model structure. The selection of variables to represent the different metabolic syndrome components and model specification explained why previous exploratory and confirmatory factor analysis, respectively, failed to identify a single factor for the metabolic syndrome. CONCLUSIONS—These analyses support the current clinical definition of the metabolic syndrome, as well as the existence of a single factor that links all of the core components.