RT Journal Article
SR Electronic
T1 Association of Intrauterine Exposure to Maternal Diabetes and Obesity With Type 2 Diabetes in Youth
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 1422
OP 1426
DO 10.2337/dc07-2417
VO 31
IS 7
A1 Dabelea, Dana
A1 Mayer-Davis, Elizabeth J.
A1 Lamichhane, Archana P.
A1 D'Agostino, Ralph B.
A1 Liese, Angela D.
A1 Vehik, Kendra S.
A1 Narayan, K.M. Venkat
A1 Zeitler, Phillip
A1 Hamman, Richard F.
YR 2008
UL http://care.diabetesjournals.org/content/31/7/1422.abstract
AB OBJECTIVE—Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. These associations were explored in African-American, Hispanic, and non-Hispanic white youth participating in the SEARCH Case-Control Study. RESEARCH DESIGN AND METHODS—A total of 79 youth with type 2 diabetes and 190 nondiabetic control youth aged 10–22 years attended a research visit. In utero exposures to maternal diabetes and obesity were recalled by biological mothers. RESULTS—Youth with type 2 diabetes were more likely to have been exposed to maternal diabetes or obesity in utero than were nondiabetic control youth (P < 0.0001 for each). After adjusting for offspring age, sex, and race/ethnicity, exposure to maternal diabetes (odds ratio [OR] 5.7 [95% CI 2.4–13.4]) and exposure to maternal obesity (2.8 [1.5–5.2]) were independently associated with type 2 diabetes. Adjustment for other perinatal and socioeconomic factors did not alter these associations. When offspring BMI was added, the OR for the association between in utero exposure to obesity and type 2 diabetes was attenuated toward the null (OR 1.1 [0.5–2.4]). Overall, 47.2% (95% CI 30.9–63.5) of type 2 diabetes in youth could be attributed to intrauterine exposure to maternal diabetes and obesity. CONCLUSIONS—Intrauterine exposures to maternal diabetes and obesity are strongly associated with type 2 diabetes in youth. Prevention efforts may need to target, in addition to childhood obesity, the increasing number of pregnancies complicated by obesity and diabetes.