PT - JOURNAL ARTICLE AU - Guy, John AU - Ogden, Lorraine AU - Wadwa, R. Paul AU - Hamman, Richard F. AU - Mayer-Davis, Elizabeth J. AU - Liese, Angela D. AU - D'Agostino, Ralph AU - Marcovina, Santica AU - Dabelea, Dana TI - Lipid and Lipoprotein Profiles in Youth With and Without Type 1 Diabetes AID - 10.2337/dc08-1775 DP - 2009 Mar 01 TA - Diabetes Care PG - 416--420 VI - 32 IP - 3 4099 - http://care.diabetesjournals.org/content/32/3/416.short 4100 - http://care.diabetesjournals.org/content/32/3/416.full SO - Diabetes Care2009 Mar 01; 32 AB - OBJECTIVE—The purpose of this study was to compare the lipid profile and the prevalence of lipid abnormalities in youth with and without type 1 diabetes and explore the role of glycemic control on the hypothesized altered lipid profile in youth with type 1 diabetes. RESEARCH DESIGN AND METHODS—We conducted a cross-sectional analysis of 512 youth with type 1 diabetes (mean duration 4.22 years) and 188 healthy control subjects aged 10–22 years in Colorado and South Carolina. SEARCH for Diabetes in Youth (SEARCH) participants with type 1 diabetes and healthy control subjects recruited from primary care offices in the same geographic regions were invited to attend a research visit. Fasting lipid profiles were compared between youth with type 1 diabetes (stratified according to categories of optimal [A1C <7.5%] and suboptimal [A1C ≥7.5%] glycemic control) and healthy nondiabetic youth, using multiple linear and logistic regression. RESULTS—Youth with type 1 diabetes and optimal A1C had lipid concentrations that were similar (total cholesterol, LDL cholesterol, and LDL particle size) or even less atherogenic (HDL cholesterol, non-HDL cholesterol, triglyceride, and triglyceride–to–HDL cholesterol ratio) than those observed in nondiabetic youth, whereas youth with suboptimal glycemic control had elevated standard lipid levels (total cholesterol, LDL cholesterol, and non-HDL cholesterol). Youth with type 1 diabetes also had significantly elevated apolipoprotein B levels and more small, dense LDL particles than nondiabetic youth, regardless of glycemic control. CONCLUSIONS—Youth with type 1 diabetes have abnormal lipid levels and atherogenic changes in lipoprotein composition, even after a relatively short disease duration. As in adults, glycemic control is an important mediator of these abnormalities.