PT  - JOURNAL ARTICLE
AU  - Noel, Rebecca A.
AU  - Braun, Daniel K.
AU  - Patterson, Ruth E.
AU  - Bloomgren, Gary L.
TI  - Increased Risk of Acute Pancreatitis and Biliary Disease Observed in Patients With Type 2 Diabetes
AID  - 10.2337/dc08-1755
DP  - 2009 May 01
TA  - Diabetes Care
PG  - 834--838
VI  - 32
IP  - 5
4099  - http://care.diabetesjournals.org/content/32/5/834.short
4100  - http://care.diabetesjournals.org/content/32/5/834.full
SO  - Diabetes Care2009 May 01; 32
AB  - OBJECTIVE The objective of this study was to assess the risk of acute pancreatitis in patients with type 2 diabetes compared with that in patients without diabetes. We also examined the risk of biliary disease (defined as occurrence of cholelithiasis, acute cholecystitis, or cholecystectomy), which is a major cause of pancreatitis. RESEARCH DESIGN AND METHODS We conducted a retrospective cohort study using a large, geographically diverse U.S. health care claims database. Eligible patients (≥18 years) were enrolled for at least 12 continuous months (1999–2005), with no incident events of pancreatitis or biliary disease during that 1 year baseline period. ICD-9 codes and prescription data were used to identify patients with type 2 diabetes; ICD-9 codes were also used to identify cases of pancreatitis and biliary disease. Overall, 337,067 patients with type 2 diabetes were matched on age and sex with 337,067 patients without diabetes. Incidence rates of disease and 95% CI were calculated per 100,000 person-years of exposure. RESULTS The type 2 diabetic cohort had a 2.83-fold (95% CI 2.61–3.06) greater risk of pancreatitis and 1.91-fold (1.84–1.99) greater risk of biliary disease compared with the nondiabetic cohort. Relative to patients of corresponding age without diabetes, younger type 2 diabetic patients had the highest risk of pancreatitis (&amp;lt;45 years: incidence rate ratio [IRR] 5.26 [95% CI 4.31–6.42]; ≥45 years: 2.44 [2.23–2.66]). CONCLUSIONS These data suggest that patients with type 2 diabetes may have an increased risk of acute pancreatitis and biliary disease.