PT  - JOURNAL ARTICLE
AU  - van Dijk, Aimée E.
AU  - Olthof, Margreet R.
AU  - Meeuse, Joke C.
AU  - Seebus, Elin
AU  - Heine, Rob J.
AU  - van Dam, Rob M.
TI  - Acute Effects of Decaffeinated Coffee and the Major Coffee Components Chlorogenic Acid and Trigonelline on Glucose Tolerance
AID  - 10.2337/dc09-0207
DP  - 2009 Jun 01
TA  - Diabetes Care
PG  - 1023--1025
VI  - 32
IP  - 6
4099  - http://care.diabetesjournals.org/content/32/6/1023.short
4100  - http://care.diabetesjournals.org/content/32/6/1023.full
SO  - Diabetes Care2009 Jun 01; 32
AB  - OBJECTIVE Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. RESEARCH DESIGN AND METHODS We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men. RESULTS Chlorogenic acid and trigonelline ingestion significantly reduced glucose (−0.7 mmol/l, P = 0.007, and −0.5 mmol/l, P = 0.024, respectively) and insulin (−73 pmol/l, P = 0.038, and −117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo. CONCLUSIONS Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.