RT Journal Article
SR Electronic
T1 Is Pulse Pressure a Predictor of New-Onset Diabetes in High-Risk Hypertensive Patients?
JF Diabetes Care
JO Diabetes Care
FD American Diabetes Association
SP 1122
OP 1127
DO 10.2337/dc09-1447
VO 33
IS 5
A1 Yasuno, Shinji
A1 Ueshima, Kenji
A1 Oba, Koji
A1 Fujimoto, Akira
A1 Hirata, Masakazu
A1 Ogihara, Toshio
A1 Saruta, Takao
A1 Nakao, Kazuwa
YR 2010
UL http://care.diabetesjournals.org/content/33/5/1122.abstract
AB OBJECTIVE Hypertensive patients have an increased risk of developing diabetes. Accumulating evidence suggests a close relation between metabolic disturbance and increased arterial stiffness. Here, we examined the association between pulse pressure and the risk of new-onset diabetes in high-risk Japanese hypertensive patients. RESEARCH DESIGN AND METHODS The Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial examined the effects of candesartan and amlodipine on the incidence of cardiovascular events in 4,728 high-risk Japanese hypertensive patients. In the present study, we analyzed the relationship between pulse pressure at baseline and new-onset diabetes in 2,685 patients without diabetes at baseline (male 1,471; mean age 63.7 years; mean BMI 24.8 kg/m2) as a subanalysis of the CASE-J trial. RESULTS During 3.3 ± 0.8 years of follow-up, 97 patients (3.6%) developed diabetes. In multiple Cox regression analysis, pulse pressure was an independent predictor for new-onset diabetes (hazard ratio [HR] per 1 SD increase 1.44 [95% CI 1.15–1.79]) as were male sex, BMI, and additional use of diuretics, whereas age and heart rate were not. Plots of HRs for new-onset diabetes considering both systolic and diastolic blood pressure (DBP) revealed that a higher pulse pressure with a lower DBP, indicating that the increased pulse pressure was largely due to increased arterial stiffness, was strongly associated with the risk of new-onset diabetes. CONCLUSIONS Pulse pressure is an independent predictor of new-onset diabetes in high-risk Japanese hypertensive patients. Increased arterial stiffness may be involved in the development of diabetes. © 2010 by the American Diabetes Association.