PT  - JOURNAL ARTICLE
AU  - Beulens, Joline W.J.
AU  - van der A, Daphne L.
AU  - Grobbee, Diederick E.
AU  - Sluijs, Ivonne
AU  - Spijkerman, Annemieke M.W.
AU  - van der Schouw, Yvonne T.
TI  - Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes
AID  - 10.2337/dc09-2302
DP  - 2010 Aug 01
TA  - Diabetes Care
PG  - 1699--1705
VI  - 33
IP  - 8
4099  - http://care.diabetesjournals.org/content/33/8/1699.short
4100  - http://care.diabetesjournals.org/content/33/8/1699.full
SO  - Diabetes Care2010 Aug 01; 33
AB  - OBJECTIVE To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20–70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66–0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87–1.00) for each 10-μg increment in the multivariate model. CONCLUSIONS This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.